Endothelial Dysfunction Role During COVID-19

Endothelial Dysfunction Role During COVID-19

Emerging data suggest a crucial role of endothelial dysfunction during SARS-CoV-2 infection, as a direct target of the virus and inflammatory cytokines as well as the main actor in orchestrating a pro-inflammatory and pro-coagulant... read more

Gastrointestinal Complications in Critically Ill Patients With and Without COVID-19

Gastrointestinal Complications in Critically Ill Patients With and Without COVID-19

This study found a higher rate of gastrointestinal complications, including mesenteric ischemia, in critically ill patients with COVID-19 compared with propensity score–matched patients without COVID-19, suggesting a distinct... read more

Fibrin-derived Peptide as Salvage Treatment in Critically Ill Patients with COVID-19-associated ARDS

Fibrin-derived Peptide as Salvage Treatment in Critically Ill Patients with COVID-19-associated ARDS

After SARS-CoV-2 first occurred in China in December of 2019, it set out to become a global pandemic. Critically ill patients constitute about 2–9% of all infected patients and progress from pneumonia and hypoxemia to multi-organ... read more

How Severe COVID-19 Infection is Changing ARDS Management

How Severe COVID-19 Infection is Changing ARDS Management

The COVID-19 pandemic has provided many intensivists (and some non-intensivists) several years' worth of severe ARDS management experience over the course of just a few months. While the challenges have, in places, been extreme,... read more

Coagulopathy of COVID-19

Coagulopathy of COVID-19

Severe acute respiratory syndrome coronavirus 2/coronavirus disease 2019 frequently induces hypercoagulability with both microangiopathy and local thrombus formation, and a systemic coagulation defect that leads to large... read more

ECMO During the Coronavirus Disease 2019 Pandemic

ECMO During the Coronavirus Disease 2019 Pandemic

In the midst of the 2009 influenza A H1N1 pandemic, clinicians turned to extracorporeal membrane oxygenation (ECMO) as a strategy to save lives. Based on the H1N1 experience, and the ECMO to Rescue Lung Injury in Severe... read more

Asthma Among Hospitalized Patients with COVID-19 and Related Outcomes

Asthma Among Hospitalized Patients with COVID-19 and Related Outcomes

Among hospitalized patients 65 years or younger with severe COVID-19, asthma diagnosis was not associated with worse outcomes, regardless of age, obesity, or other high-risk comorbidities. Future population-based studies... read more

Awake Prone Positioning for COVID-19 Hypoxemic Respiratory Failure

Awake Prone Positioning for COVID-19 Hypoxemic Respiratory Failure

Infection with SARS-CoV-2 can result in Coronavirus Disease–19 (COVID-19). While the majority of patients are asymptomatic or have mild disease, approximately 14% develop more severe disease including hypoxemic respiratory... read more

Plasma Exchange in Critically Ill COVID-19 Patients

Plasma Exchange in Critically Ill COVID-19 Patients

The spectrum of coronavirus disease 2019 (COVID-19) ranges from asymptomatic infection to respiratory failure and death of patients. Severely affected patients may develop a cytokine storm-like clinical syndrome with multi-organ... read more

Laboratory Features of Severe vs. Non-severe COVID-19 Patients in Asian Populations

Laboratory Features of Severe vs. Non-severe COVID-19 Patients in Asian Populations

This meta-analysis provides evidence for the differentiation of severe cases of COVID-19 based on laboratory test results at the time of ICU admission. Future well-methodologically designed studies from other populations... read more

Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and ARDS

Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and ARDS

In this preliminary study of patients with sepsis and ARDS, a 96-hour infusion of vitamin C compared with placebo did not significantly improve organ dysfunction scores or alter markers of inflammation and vascular injury.... read more

The Use of ECMO in Patients with Cardiopulmonary Failure Due to COVID-19

The Use of ECMO in Patients with Cardiopulmonary Failure Due to COVID-19

COVID-19 related cardiopulmonary failure such as ARDS and cardiogenic shock or massive pulmonary embolism can be successfully supported with ECMO. Judicious patient selection is important to enable maximal benefit and optimized... read more

Serum Levels of Receptor-interacting Protein Kinase-3 in Patients with COVID-19

Serum Levels of Receptor-interacting Protein Kinase-3 in Patients with COVID-19

Patients with coronavirus disease 2019 (COVID-19) can develop acute respiratory distress syndrome (ARDS), which has been linked to poor prognosis and is a major contributor to patient death. A better understanding of the... read more

Inhaled Pulmonary Vasodilators

Inhaled Pulmonary Vasodilators

Confusion between inhaled versus intravenous routes for pulmonary vasodilators. For optimal clinical benefit (especially regarding oxygenation), these agents must be given via an inhaled route. The misconception that inhaled... read more