Case Files Critical Care (LANGE Case Files)

Case Files Critical Care (LANGE Case Files)

Experience with clinical cases is key to mastering the art and science of medicine and ultimately to providing patients with competent clinical care. Case Files: Critical Care provides 42 true-to-life cases that illustrate... read more

Managing Patients With Short-Term Mechanical Circulatory Support

Managing Patients With Short-Term Mechanical Circulatory Support

The use of mechanical circulatory support for patients presenting with cardiogenic shock is rapidly increasing. Currently, there is only limited and conflicting evidence available regarding the role of the Impella (a microaxial,... read more

Norepinephrine Dosing Error Associated with Multiple Health System Vulnerabilities

Norepinephrine Dosing Error Associated with Multiple Health System Vulnerabilities

Vasopressors are commonly used in the treatment of shock to support blood pressure, cardiac output, and end-organ perfusion. These agents are associated with risk of serious adverse effects including ischemia (e.g. stroke,... read more

Major Trauma Definition Using Different Revisions of the Abbreviated Injury Scale

Major Trauma Definition Using Different Revisions of the Abbreviated Injury Scale

Injury Severity Score (ISS) 08 ≥ 11 and ISS 15 ≥ 12 perform similarly to a threshold ISS 98 ≥ 16 for in-hospital mortality and ICU admission. This confirms studies evaluating mapped datasets, and is the... read more

Variation in Pediatric Palliative Care Allocation Among Critically Ill Children in the United States

Variation in Pediatric Palliative Care Allocation Among Critically Ill Children in the United States

Palliative care consultation for critically ill children in the United States is low. Palliative care utilization is increasing but considerable variation exists across institutions, suggesting inequity in palliative care... read more

Safety profile of enhanced thromboprophylaxis strategies for critically ill COVID-19 patients

Safety profile of enhanced thromboprophylaxis strategies for critically ill COVID-19 patients

In a cohort of critically ill patients with a high prevalence of thromboembolic events, ET was associated with reduced ICU mortality without an increased burden of haemorrhagic complications. This study suggests ET strategies... read more

Checklist for Early Recognition and Treatment of Acute Illness and Injury

Checklist for Early Recognition and Treatment of Acute Illness and Injury

A quality-improvement intervention with remote simulation training to implement a decision support tool was associated with decreased nonadherence to daily care processes, shorter length of stay, and decreased mortality. The... read more

Sedation, Analgesia, and Paralysis in COVID-19 Patients in the Setting of Drug Shortages

Sedation, Analgesia, and Paralysis in COVID-19 Patients in the Setting of Drug Shortages

The rapid spread of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has led to a global pandemic. The 2019 coronavirus disease (COVID-19) presents with a spectrum of symptoms ranging from mild to critical... read more

Virtual Reality Tailored to the Needs of Post-ICU Patients

Virtual Reality Tailored to the Needs of Post-ICU Patients

ICU-specific virtual reality appears safe and more immersive than 2D, implicating that ICU-specific virtual reality is feasible for clinical use. One should however be aware of simulator sickness-related symptoms. Future... read more

Randomised controlled trials in pre-hospital trauma

Randomised controlled trials in pre-hospital trauma

This mapping review has highlighted that evidence from trials in prehospital trauma is sparse and where trials have been completed, the reporting is generally poor and study designs sub-optimal. There is a continued need,... read more

Rapid Sequence Induction: Where Did the Consensus Go?

Rapid Sequence Induction: Where Did the Consensus Go?

The conduct of Rapid Sequence Induction (RSI) in current emergency practice is far removed from the original descriptions of the procedure. Despite this, the principles – rapid delivery of a definitive airway and avoiding... read more

Safety of Arterial Catheterization Using the Distal Radial Approach in ICU Management

Safety of Arterial Catheterization Using the Distal Radial Approach in ICU Management

Distal radial approach (DRA) may be a safe option for insertion of a new A-line in the ICU. The study included 20 patients with a median age of 70 (interquartile range (IQR): 58.5–77) years: 10 patients with traumas,... read more

Low Technology, Mild Controlled Hypothermia for Necrotizing Enterocolitis Treatment

Low Technology, Mild Controlled Hypothermia for Necrotizing Enterocolitis Treatment

Low technology, mild controlled hypothermia was feasible, not related to adverse effects, and effective treatment for NEC Modified Bell's Stage II/III. It avoided surgery, bowel perforation, and extensive intestinal resection;... read more

Oral Midodrine Feasibility in Early Sepsis

Oral Midodrine Feasibility in Early Sepsis

This study proved the feasibility of clinical trial to use oral midodrine in early sepsis. The study was not powered to detect statistically significant differences between the two groups, and therefore, the results from... read more