AKI Defined by Fluid-Corrected Creatinine in Premature Neonates

AKI Defined by Fluid-Corrected Creatinine in Premature Neonates

In this secondary analysis of the multicenter PENUT trial, we describe fluid-corrected acute kidney injury (AKI) and evaluate associations with short-term and long-term outcomes in premature neonates with fluid-corrected... read more

The Ketamine Drive-Through

The Ketamine Drive-Through

Patients who present with unexplained urinary tract symptoms or laboratory abnormalities on tests for liver injury should be asked about exposure to ketamine. Patients who chronically use ketamine should also be screened... read more

Kidney Imaging with Point-of-Care Doppler Ultrasonography

Kidney Imaging with Point-of-Care Doppler Ultrasonography

We read with great interest the article by Caroli et al., in which they meticulously discuss the role of imaging in elucidating both structural and functional aspects of kidney disease. Herein, we would like to briefly comment... read more

Generalizable Biomarkers in Critical Care

Generalizable Biomarkers in Critical Care

The sequencing of the human genome and the subsequent availability of inexpensive, robust methods for "omics" profiling (e.g., genome-wide association studies, gene expression microarrays, and metabolomics) have... read more

Contrast-Induced Nephropathy: Confounding Causation

Contrast-Induced Nephropathy: Confounding Causation

Comparing the methodological rigor of more recent CIN studies to those in the past, it seems clear that earlier studies purporting a causal relationship between AKI and contrast administration were only identifying an association... read more

Three-year mortality in 30 day survivors of critical care with AKI

Three-year mortality in 30 day survivors of critical care with AKI

Acute kidney injury was not an independent risk factor for 3-year mortality among 30-day survivors. Increased 3-year mortality among patients with AKI who survive critical illness may not be related to AKI per se, but rather... read more

Effect of atorvastatin on the incidence of acute kidney injury following valvular heart surgery

Effect of atorvastatin on the incidence of acute kidney injury following valvular heart surgery

Statins, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors have the potential to reduce acute kidney injury (AKI) after cardiac surgery through their pleiotropic properties. Here we studied the preventive... read more