Acute Kidney Injury in Postoperative Shock

Acute Kidney Injury in Postoperative Shock

Is hyperoncotic albumin administration an unrecognized resuscitation risk factor? The use of hyperoncotic albumin (HA) for shock resuscitation is controversial given concerns about its cost, effectiveness, and potential for... read more

Plasma Volume, Tissue Oedema, and the Steady-state Starling Principle

Plasma Volume, Tissue Oedema, and the Steady-state Starling Principle

The Michel–Weinbaum steady-state Starling principle has important consequences for clinical practice. The hope that biophysical intravascular colloid therapy with albumin or plasma substitutes can deliver plasma volume... read more

Moving Albumin Into the Small Volume Resuscitation Era

Moving Albumin Into the Small Volume Resuscitation Era

Physicians have an intense 70-year history of enthusiasm, skepticism, fear, and reconciliation with albumin products since their market introduction in the late 1940s. Despite its cumbersome production method and costs, albumin... read more

Fluid Management in Cardiac Surgery

Fluid Management in Cardiac Surgery

Perioperative fluid management in cardiac surgery patients may have changed in the last few years in European centers. Balanced crystalloids now seem to be the preferred solutions, followed by synthetic colloids (mainly gelatins)... read more

Simultaneous assessment of the synthesis rate and transcapillary escape rate of albumin in inflammation and surgery

Simultaneous assessment of the synthesis rate and transcapillary escape rate of albumin in inflammation and surgery

Single measurements of the synthesis rate and/or transcapillary escape rate of albumin obviously cannot explain the plasma level of albumin or the changes seen in plasma albumin concentration.... read more