Tag: antimicrobial

Upvote Story 6
Ventilator-associated pneumonia (VAP) remains a serious complication of mechanical ventilation (MV), and has an incidence between 2 and 16 episodes per 1000 ventilator-days, an attributable mortality of 5–13%, excess ICU length of stay (LOS) for survivors up to 9 days, and extra costs. Many studies have reported decreased VAP rates associated with the use of bundles of preventive measures. Fewer studies have reported compliance with... Read More | Comment
Upvote Story 16
Only few new molecules have an adequate activity against MDR gram-negative pathogens, especially carbapenemase-producer strains. Among these, ceftozolane/tazobactam has been recently approved for clinical use. Other compounds, such as avibactam combinations, plazomicin, and eravacycline, have shown promising activity in phase 2 and 3 clinical trials. A limited number of large trials have assessed the treatment options for commonly encountered resistant pathogens Read More | Comment
Upvote Story 12
Defining the optimal treatment of Central Nervous System (CNS) infections is one of the most challenging tasks for the intensivists; the therapeutic window is narrow, and the alternative drug options more limited than with any other severe infectious diseases. Progress has been achieved, especially with clinical studies on drug concentrations into the plasma and the cerebrospinal fluid (CSF), but many unresolved issues remain to better... Read More | Comment
Upvote Story 28
Joining the ranks of popular science classics like The Botany of Desire and The Selfish Gene, a groundbreaking, wondrously informative, and vastly entertaining examination of the most significant revolution in biology since Darwin. A “microbe’s-eye view” of the world that reveals a marvelous, radically reconceived picture of life on earth. Every animal, whether human, squid, or wasp, is home to millions of bacteria and other... Read More | Comment
Upvote Story 3
Antimicrobial-resistant infections affect more than 2 million people annually in the United States alone, accounting for an estimated 23 000 deaths and estimated economic costs of $55 billion. Recent projections suggest that an estimated 300 million people worldwide could die prematurely in the next 35 years because of antimicrobial-resistant infections. Physicians are more frequently prescribing antibiotics of last resort (such as colistin and carbapenem), raising concerns... Read More | Comment
Upvote Story 5
Sepsis most often presents to the emergency department (ED), and delayed detection is harmful. The white blood count (WBC) is often used to detect sepsis in the ED. New research shows that volume increases of circulating immune cells, or monocytes, adds value to the WBC for early sepsis detection in the ED. This study shows that the monocyte distribution width (MDW), a measure of a... Read More | Comment
Upvote Story 4
Rapid diagnostic tests detecting microbial resistance are needed for limiting the duration of inappropriateness of empirical antimicrobial therapy (EAT) in ICU patients, besides reducing the use of broad-spectrum antibiotics. We hypothesized that the betaLACTA test (BLT) could lead to early increase in the adequacy of antimicrobial therapy. Our study suggests that a BLT-guided adaptation strategy may allow early beta-lactam adaptation from the first 24 hours... Read More | Comment