Meralgia Paresthetica: COVID-19-associated ARDS treated with prone positioning

Meralgia Paresthetica: COVID-19-associated ARDS treated with prone positioning

Prone positioning is one of the few interventions in acute respiratory distress syndrome (ARDS) which has a proven mortality reduction. Due to the coronavirus disease 2019 (COVID-19) pandemic, severe ARDS cases have sharply... read more

Basics of Mechanical Ventilation

Basics of Mechanical Ventilation

This book is a practical and easily understandable guide for mechanical ventilation. With a focus on the basics, this text begins with a detailed account of the mechanisms of spontaneous breathing as a reference point to... read more

Subtle Presentations of Shock in the ED Setting

Subtle Presentations of Shock in the ED Setting

The patient was a 2-year-old female with a history of allergy to peanuts who was brought to the emergency department by her mother because of a complaint of allergic reaction. Twenty minutes prior to arrival, the patient... read more

Harnessing a Pioneering Cell Therapy Treatment for COVID-19 Patients with ARF

Harnessing a Pioneering Cell Therapy Treatment for COVID-19 Patients with ARF

A world-leading UK-wide trial supported by NIHR is offering a pioneering cell therapy treatment for patients with acute respiratory failure (ARF) caused by COVID-19. The groundbreaking study, led by experts at Queen's... read more

COVID-19 Pneumonia: Typical or Atypical Form of ARDS?

COVID-19 Pneumonia: Typical or Atypical Form of ARDS?

Evidence-based guidelines can never help a doctor resolve whether a patient is best managed by inserting an endotracheal tube or avoiding its use. That decision is based on clinical judgment, gestalt, and tacit knowledge.... read more

Circuits Between Infected Macrophages and T Cells in COVID-19 Pneumonia

Circuits Between Infected Macrophages and T Cells in COVID-19 Pneumonia

Some patients infected with Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) develop severe pneumonia and the acute respiratory distress syndrome (ARDS). Distinct clinical features in these patients have led... read more

Trauma ICU Rounds – The rEVOLUTION of ECMO

Trauma ICU Rounds – The rEVOLUTION of ECMO

What are the indications for ECMO beyond ARDS and refractory cardiogenic shock? In which patients should we consider eCPR and is this the new standard of care for patients sustaining out-of-hospital cardiac arrest? Finally,... read more

The Value of Decreasing the Duration of the Infectious Period of Severe ARDS COVID-19 Infection

The Value of Decreasing the Duration of the Infectious Period of Severe ARDS COVID-19 Infection

Finding medications or vaccines that may decrease the infectious period of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could potentially reduce transmission in the broader population. We developed a computational... read more

Transfusion Associated Circulatory Overload

Transfusion Associated Circulatory Overload

A 67-year-old female with a history of congestive heart failure and CKD was brought in by ambulance from her nursing home for a gastrointestinal bleed. The patient’s total fluid balance from her nursing home was 2.5L over... read more

Lactoferrin for the Treatment of COVID‑19

Lactoferrin for the Treatment of COVID‑19

The coronavirus disease 2019 (COVID‑19) outbreak was caused by infection with the severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2). The clinical outcomes of elderly individuals and those with underlying... read more

Mitochondrial Damage-Associated Molecular Patterns Exacerbate Lung Fluid Imbalance Via the Formyl Peptide Receptor-1 Signaling Pathway in Acute Lung Injury

Mitochondrial Damage-Associated Molecular Patterns Exacerbate Lung Fluid Imbalance Via the Formyl Peptide Receptor-1 Signaling Pathway in Acute Lung Injury

Mitochondrial damage–associated molecular patterns exacerbate lung fluid imbalance in the experimental acute lung injury model through formyl peptide receptor-1 signaling, the inhibition of which may prevent exacerbation... read more

Pulmonary Infections Complicating ARDS

Pulmonary Infections Complicating ARDS

Pulmonary infection is one of the main complications occurring in patients suffering from acute respiratory distress syndrome (ARDS). Besides traditional risk factors, dysregulation of lung immune defenses and microbiota... read more

Improved Oxygenation After Prone Positioning May Be a Predictor of Survival in Patients With ARDS

Improved Oxygenation After Prone Positioning May Be a Predictor of Survival in Patients With ARDS

We found a significant difference in the Pao2:Fio2 ratio after the first prone positioning between ICU survivors and nonsurvivors. The improvement in oxygenation after the first prone positioning was a significant predictor... read more

Will the asthma revolution fostered by biologics also benefit adult ICU patients?

Will the asthma revolution fostered by biologics also benefit adult ICU patients?

Asthma exacerbations are inflammatory events that rarely result in full hospitalization following an ER visit. Unfortunately, certain patients require prolonged support, including occasional external lung support through... read more