Bringing Biological ARDS Phenotypes to the Bedside with Machine-learning-based Classifiers

Bringing Biological ARDS Phenotypes to the Bedside with Machine-learning-based Classifiers

The identification of distinct phenotypes within heterogeneous disease states is a key component of personalised medicine, enabling enrichment of clinical trials, better prognostication, and delivery of tailored treatments... read more

Biomarker-guided Steroid Dosing in COVID-19 Pneumonia

Biomarker-guided Steroid Dosing in COVID-19 Pneumonia

Although corticosteroid administration has been associated with improved outcomes in severe COVID-19 pneumonia, their ideal use remains undefined with a "one size fits all" approach used, irrespective of the individual inflammatory... read more

Prognostic and Predictive Biomarkers in COVID-19 Patients Treated with Tocilizumab

Prognostic and Predictive Biomarkers in COVID-19 Patients Treated with Tocilizumab

Multiple biomarkers prognostic for clinical outcomes were confirmed in COVACTA. Ferritin was identified as a predictive biomarker for the effects of tocilizumab in the COVACTA patient population; high ferritin levels were... read more

Identification of Biomarkers, New Treatments, and Vaccines for COVID-19

Identification of Biomarkers, New Treatments, and Vaccines for COVID-19

The novel coronavirus 2019 (COVID-19) has caused a serious global pandemic in just one year. Nearly every country and territory in the world has been affected by the virus. The virulence and infection rate of the virus are... read more

Safety and Efficacy of MUST-ARDS

Safety and Efficacy of MUST-ARDS

This important first study, using multipotent adult progenitor cells in ARDS patients (MUST-ARDS), was a phase 1/2 randomised, blinded, placebo-controlled trial that demonstrated safety and tolerability of intravenous administration... read more

MR-proADM Role in the Stratification Risk of COVID-19 Patients Assessed at the Triage of the Emergency Department

MR-proADM Role in the Stratification Risk of COVID-19 Patients Assessed at the Triage of the Emergency Department

During the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, the Emergency Departments have been overrun with suspicious COVID-19 patients, creating a pressing need to optimize resources through risk... read more

Pre-hospital suPAR, Lactate and CRP Measurements for Decision-making

Pre-hospital suPAR, Lactate and CRP Measurements for Decision-making

Pre-hospital suPAR measurements alone or combined with C-reactive protein (CRP) and/or lactate measurements could not predict the ED discharge or hospital admission of 109 non-urgent EMS patients with non-specific chief complaints... read more

Serum markers of brain injury can predict good neurological outcome after out-of-hospital cardiac arrest

Serum markers of brain injury can predict good neurological outcome after out-of-hospital cardiac arrest

Low levels of brain injury markers in blood are associated with good neurological outcome after CA. Incorporating biomarkers into neuroprognostication may help prevent premature withdrawal of life-sustaining therapy. Retrospective... read more

Predicting Adverse Outcomes in COVID-19 Patients Using BV5%

Predicting Adverse Outcomes in COVID-19 Patients Using BV5%

Evidence suggests that vascular inflammation and thrombosis may be important drivers of poor clinical outcomes in patients with COVID-19. We hypothesized that a significant decrease in the percentage of blood vessels with... read more

Baseline FeNO as a prognostic biomarker for subsequent severe asthma exacerbations

Baseline FeNO as a prognostic biomarker for subsequent severe asthma exacerbations

In uncontrolled, moderate-to-severe asthma, higher baseline FeNO levels were associated with greater risk of severe asthma exacerbations, particularly in combination with elevated eosinophil count and prior exacerbations,... read more

Diagnostic accuracy of prehospital serum S100B and GFAP in patients with mild TBI

Diagnostic accuracy of prehospital serum S100B and GFAP in patients with mild TBI

Early prehospital and in-hospital S100B levels  0.10 μg/L was 100% (95%CI: 89.1;100.0) in prehospital samples and 100% (95% CI 89.1;100.0) in in-hospital samples. The specificity was 15.4% (95%CI: 12.4;18.7) in prehospital... read more

Neurological Complications Acquired During Pediatric Critical Illness

Neurological Complications Acquired During Pediatric Critical Illness

Graphical models that include biomarkers in addition to clinical data are promising methods to evaluate direct relationships in the development of neurologic complications in critically ill children. Future work is required... read more

Cardiac Markers Implication in Risk-stratification and Management for COVID-19 Patients

Cardiac Markers Implication in Risk-stratification and Management for COVID-19 Patients

COVID-19 patients with pre-existing coronary artery disease represented a higher abnormal percentage of cardiac markers, accompanied by high mortality and ICU admission rate. BNP together with hs-TNI, α- HBDH, CK-MB and... read more

Host Endothelial, Epithelial and Inflammatory Response in ICU COVID-19 Patients

Host Endothelial, Epithelial and Inflammatory Response in ICU COVID-19 Patients

These studies demonstrate that, unlike other well-studied causes of critical illness, endothelial dysfunction may not be characteristic of severe COVID-19 early after ICU admission. Pathways resulting in elaboration of acute... read more