Upvote Story 4
We read with great interest the recent letter to Critical Care by Marik and Hooper. Vitamin C is increasingly recognized as a crucial compound to alleviate morbidity in critically ill patients. Vitamin C concentrations, however, are usually far below normal and even close to “scurvy levels” in this population. Vitamin C also is substantially cleared by continuous renal replacement therapy (CRRT). Significant vitamin C deficiency... Read More | Comment
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Despite high dialysability, dialysis clearance displayed only a minor contribution to tigecycline elimination, being in the range of renal elimination in patients without AKI. No dose adjustment of tigecycline seems necessary in continuous renal replacement therapy (CRRT). A two-compartment population pharmacokinetic (PK) model was suitable to simultaneously describe the plasma PK and effluent measurements of tigecycline. Tigecycline dialysability was high, as indicated by the high... Read More | Comment
Upvote Story 6
We developed a prioritized list of 13 QIs for continuous renal replacement therapy (CRRT) care. Future work should focus on developing validated benchmarks for these QIs and implementing them into CRRT programs. We conducted a modified three stage Delphi process. This consisted of two web-based rounds followed by an in-person meeting. We recruited an interdisciplinary panel of critical care nephrology experts and knowledge users. In... Read More | Comment
Upvote Story 22
ICU patients are high risk of developing thrombotic complications such as deep venous thrombosis (DVT) and pulmonary embolism (PE). Indeed, due to the hypercoagulative state typical for many forms of critical illness associated with risk factors as prolonged immobilization or the use of intravascular devices, ICU patients are at higher risk for thrombotic complications. Read More | Comment
Upvote Story 4
Based on recent recommendations, the use of Regional Citrate Anticoagulation (RCA) is likely to increase dramatically throughout the world. RCA protocols should aim to minimize the amount of net citrate load delivered to the patient. In case of acid-base derangement during RCA, clinicians should be able to differentiate a benign citrate net overload (alkalosis) from a life-threatening accumulation (elevated Ca/Ca++, increase need for calcium substitution,... Read More | Comment