Melatonin for Delirium Prevention in Hospitalized Patients

Melatonin for Delirium Prevention in Hospitalized Patients

Melatonin/ramelteon are associated with reduction in delirium incidence in hospitalized patients. However, this effect seems confined to surgical and ICU patients. The optimum dosage and formulation of melatonin, and... read more

Dealing with missing delirium assessments in prospective clinical studies of the critically ill

Dealing with missing delirium assessments in prospective clinical studies of the critically ill

For longitudinal data where a summary exposure is of interest, we recommend practitioners adopting the passive imputation strategy. Simulations show that all methods performed comparably when the proportion of missingness... read more

The Relationship of Delirium, Sedation, Dementia, and Acquired Weakness

The Relationship of Delirium, Sedation, Dementia, and Acquired Weakness

The advent of modern critical care medicine has revolutionized care of the critically ill patient in the last 50 years. The Society of Critical Care Medicine (was formed in recognition of the challenges and need for specialized... read more

Delirium and long term cognition in critically ill patients

Delirium and long term cognition in critically ill patients

Delirium, a form of acute brain dysfunction, is very common in the critically ill adult patient population. Although its pathophysiology is poorly understood, multiple factors associated with delirium have been identified,... read more

Multicomponent Non-pharmacological Intervention on Delirium and Sleep Quality in SICU

Multicomponent Non-pharmacological Intervention on Delirium and Sleep Quality in SICU

Delirium is a deleterious condition affecting up to 60% of patients in the surgical intensive care unit (SICU). Few SICU-focused delirium interventions have been implemented, including those addressing sleep-wake disruption,... read more

Haloperidol and Quetiapine for the Treatment of ICU-Associated Delirium in a Tertiary Pediatric ICU

Haloperidol and Quetiapine for the Treatment of ICU-Associated Delirium in a Tertiary Pediatric ICU

In our small, single-center study, patients treated with haloperidol or quetiapine showed no short-term improvement in delirium screening scores after starting treatment when compared with untreated, propensity score-matched... read more

Delirium (PRE-DELIRIC) Prediction Model for ICU Patients

Delirium (PRE-DELIRIC) Prediction Model for ICU Patients

The recalibrated PRE-DELIRIC model (version 2) for intensive care patients consists of 10 risk factors that are readily available within 24 hours after intensive care admission and has a high predictive value. The model allows... read more

Haloperidol, Clonidine and Resolution of Delirium in Critically Ill Patients

Haloperidol, Clonidine and Resolution of Delirium in Critically Ill Patients

Haloperidol and clonidine use in delirious ICU patients may be associated with reduced probability of delirium resolution. This finding, however, merits further investigation given inherent limitations of this observational... read more

Delirium Incidence, Duration, and Severity in Critically Ill Patients with COVID-19

Delirium Incidence, Duration, and Severity in Critically Ill Patients with COVID-19

Delirium without coma occurred in 29.1% of patients admitted to the ICU. Delirium persisted for a median of 5 days and was severe. Mechanical ventilation was significantly associated with odds of delirium even after adjustment... read more

Effectiveness of Bundle Interventions on ICU Delirium

Effectiveness of Bundle Interventions on ICU Delirium

This meta-analysis fails to support that bundle interventions are effective in reducing ICU delirium prevalence and duration, but supports that bundle interventions are effective in reducing the proportion of patient-days... read more

Prone Positioning Non-intubated COVID-19 Patients with Severe Hypoxemia Was Safe

Prone Positioning Non-intubated COVID-19 Patients with Severe Hypoxemia Was Safe

In a small sample, prone positioning non-intubated COVID-19 patients with severe hypoxemia was safe; however, many patients did not tolerate prolonged durations. Although patients had improved oxygenation and respiratory... read more

Delirium Prevalence and Risk Factors for Critically Ill COVID-19 Patients

Delirium Prevalence and Risk Factors for Critically Ill COVID-19 Patients

Acute brain dysfunction was highly prevalent and prolonged in critically ill patients with COVID-19. Benzodiazepine use and lack of family visitation were identified as modifiable risk factors for delirium, and thus these... read more

ICU Delirium-Prediction Models: A Systematic Review

ICU Delirium-Prediction Models: A Systematic Review

Although most ICU delirium-prediction models have relatively good performance, they have limited applicability to clinical practice. Most models were static, making predictions based on data collected at a single time-point,... read more

Response to optic nerve sheath diameter guided detection of sepsis associated encephalopathy

Response to optic nerve sheath diameter guided detection of sepsis associated encephalopathy

regarding the blind method, being uninformed of the clinical diagnoses of patients is unavailing, since clues will still be found in patients' clinical manifestations. Therefore, two trained physicians in intensive ultrasound... read more