Blood-Pressure Targets in Comatose Survivors of Cardiac Arrest

Blood-Pressure Targets in Comatose Survivors of Cardiac Arrest

Targeting a mean arterial blood pressure of 77 mm Hg or 63 mm Hg in patients who had been resuscitated from cardiac arrest did not result in significantly different percentages of patients dying or having severe disability... read more

Ground-breaking Research – Venous Thrombosis is Back in Business

Ground-breaking Research – Venous Thrombosis is Back in Business

The primary efficacy outcome was the development of a major venous thromboembolic event such as symptomatic distal or proximal deep-vein thrombosis, asymptomatic deep vein thrombosis, pulmonary embolism or venous thromboembolism–related... read more

Functional Disability 5 Years After ARDS

Functional Disability 5 Years After ARDS

Exercise limitation, physical and psychological sequelae, decreased physical quality of life, and increased costs and use of health care services are important legacies of severe lung injury. At 5 years, the median 6-minute... read more

Life Following Pediatric Septic Shock

Life Following Pediatric Septic Shock

Margaret M. Parker, MD, MCCM, and Jerry J. Zimmerman, MD, PhD, FCCM, talk about the trajectory of long-term mortality and significant health-related quality of life disability among children encountering septic shock. This... read more

Risk Factors for Septicemia Deaths and Disparities in a Longitudinal US Cohort

Risk Factors for Septicemia Deaths and Disparities in a Longitudinal US Cohort

In this cohort, the major risk factors for septicemia death were similar to those for other causes of death, there was approximately a 2-fold Black-White disparity in septicemia deaths, and the strongest mediators of this... read more

Cognitive impairment in chronic obstructive pulmonary disease: disease burden, determinants and possible future interventions

Cognitive impairment in chronic obstructive pulmonary disease: disease burden, determinants and possible future interventions

Cognitive impairment (CI) is an important but an under-recognized extra-pulmonary feature of chronic obstructive pulmonary disease (COPD). It is related to the burden of disability, worse health outcomes and impaired self-management.... read more

Is Tranexamic Acid Going to CRASH the Management of TBI?

Is Tranexamic Acid Going to CRASH the Management of TBI?

In the recent CRASH-3 randomized trial, early administration of tranexamic acid (TXA) was associated with a non-significant reduction of head injury-related 28-day mortality in patients with isolated traumatic brain injury... read more

When Brains Collide: What Every Athlete and Parent Should Know About the Prevention and Treatment of Concussions and Head Injuries

When Brains Collide: What Every Athlete and Parent Should Know About the Prevention and Treatment of Concussions and Head Injuries

There is nearly a 20% chance that you or someone close to you will suffer a concussion this year. Whether they are in a car accident, fall off their bike, or suffer a helmet-to-helmet hit at football practice, over 30%... read more

Amount of Muscle Mass During ICU Admission May Be Linked to Survival

Amount of Muscle Mass During ICU Admission May Be Linked to Survival

In the study cohort, ICU admission pectoralis muscle area (PMA) was associated with survival during and following critical illness; it was unable to predict regaining an independent lifestyle following discharge. ICU admission... read more

A Multidisciplinary Idea to STEP UP Resuscitation Effectiveness

A Multidisciplinary Idea to STEP UP Resuscitation Effectiveness

Non-technical skills and human factors are increasingly recognized as critical ingredients in the success or failure of acute care delivery in a number of high stakes clinical domains. This is reflected in the evolution of... read more

Long-Term Outcome after Prolonged Mechanical Ventilation

Long-Term Outcome after Prolonged Mechanical Ventilation

Among patients receiving prolonged mechanical ventilation at an LTACH, 53.7% were detached from the ventilator at discharge and 1-year survival was 66.9%. Respiratory strength was well maintained, whereas peripheral strength... read more

Association of ICU Delirium with Sleep Disturbance and Functional Disability After Critical Illness

Association of ICU Delirium with Sleep Disturbance and Functional Disability After Critical Illness

After adjusting for important covariates, total days of MICU delirium were significantly associated with increased post-discharge sleep disturbance. Delirium incidence showed a trend toward association with increased functional... read more

Even Proper Technique Exposes Nurses’ Spines To Dangerous Forces

Even Proper Technique Exposes Nurses’ Spines To Dangerous Forces

In this close-up screenshot from a simulation video, you can see the exact moment NPR correspondent Daniel Zwerdling endured dangerous levels of stress on his spine while re-creating the way nurses push their patients in... read more

Number Needed to Treat

Number Needed to Treat

Effectively communicating clinical trial results to patients and clinicians is a requirement for appropriate application in clinical practice. In a recent issue of JAMA, Zhao et al1 reported the results from a randomized... read more