Tag: hypoxia

Upvote Story 13
Cerebral auto-regulation was altered in half of the patients with sepsis and was associated with the development of SABD. These findings support the concept that cerebral hypoxia could contribute to the development of sepsis-associated brain dysfunction (SABD). Mxa was 0.29. Cerebral autoregulation (CAR) was impaired in 50 patients (50%). In a multiple linear regression analysis, low mean arterial pressure, history of chronic kidney disease and... Read More | Comment
Upvote Story 5
The treatment of choice for a pneumothorax is a chest tube, and when the small pig-tail catheter doesn’t do the job, the answer is to replace it with a larger bore – right? Not so fast. The exact mechanism of REPE is not clear. The current theory is that lung expansion leads to increased vascular permeability. Rapid inflow of blood to atelectatic lung segments results... Read More | Comment
Upvote Story 5
High-flow nasal cannula should be considered a first-line therapy in all patients with hypoxemic respiratory failure not from cardiogenic pulmonary edema and without concomitant hypercapnia. The high flow rate of HFNC offers many advantages over low flow nasal cannula and NRB that include washout of dead space leading to reduction in the work of breathing, better titration of oxygen, heated and humidified gas to promote... Read More | Comment
Upvote Story 5
The use of supplemental oxygen is of no value when treating stagnant and histotoxic hypoxia because the problem is due to impaired cardiac function and cell enzyme inhibition respectfully. Supplemental oxygen is of little value when treating anemic hypoxia because the problem is due to a lack of hemoglobin availability. The preferred method of treatment is to transfuse units of packed red blood cells (PRBCs).... Read More | Comment
Upvote Story 17
A guide to the initial emergency department management of patients with pulmonary hypertension and right ventricular failure. It is very rare for my to write about pathophysiology, but understanding the pathophysiology of the right ventricle is essential to understanding the appropriate emergency management of these patients. In the normal state, the pulmonary circulation is a low-pressure, low-resistance system. Pulmonary pressures are increased in response to... Read More | Comment
Upvote Story 11
Over the last half-decade, there has been a distinct shift in the approach to lactate elevation. The long-held belief that elevated serum lactate requires tissue or cellular hypoxia has fallen away. Indeed, in sepsis, tissues bathed in oxygen and with fully functional mitochondria can produce large amounts of lactate. Part of the confusion stems from the terms anaerobic and aerobic; anaerobic chemistry simply means that... Read More | Comment
Upvote Story 16
Emergency Department exposure to hyperoxia is common and associated with increased mortality in mechanically ventilated patients achieving normoxia after admission. This suggests that hyperoxia in the immediate post-intubation period could be particularly injurious, and targeting normoxia from initiation of mechanical ventilation may improve outcome. A total of 688 patients were included. ED normoxia occurred in 350 (50.9%) patients, and 300 (43.6%) had exposure to ED... Read More | Comment
Upvote Story 22
In septic acute kidney injury (AKI), renal medullary and urinary hypoxia developed several hours before increases in currently used biomarkers. Angiotensin II transiently improved renal function without worsening medullary hypoxia. In septic acute kidney injury, angiotensin II appears to be a safe, effective therapy, and urinary PO2 may be used to detect medullary hypoxia. Septic acute kidney injury was characterized by hypotension and a 60%... Read More | Comment
Upvote Story 4
The effective treatment of airway compromise in trauma and non-trauma patients is important. Hypoxia and hypotension are predictors of negative patient outcomes and increased mortality, and may be important quality indicators of care provided by emergency medical services. Eight hundred forty three trauma patients and 422 non-trauma patients receiving pre-hospital TI were included. Non-trauma patients had significantly lower predicted mean pre-intervention SpO2 compared to trauma... Read More | Comment
Upvote Story 5
The aim of this study was to test the hypothesis that the right ventricle is more dilated during resuscitation from cardiac arrest caused by pulmonary embolism, compared with hypoxia and primary arrhythmia. The right ventricle was more dilated during resuscitation when cardiac arrest was caused by pulmonary embolism compared with hypoxia and primary arrhythmia. However, the right ventricle was dilated, irrespective of the cause of... Read More | Comment
Upvote Story 6
New research shows that low oxygen therapy is able to eliminate brain lesions developed from mitochondrial dysfunction in mice. Eventually, hypoxia therapy could be used to treat people with similar disorders and maybe even reverse signs of aging in otherwise healthy individuals. Even more exciting was what happened when mice who already had brain lesions were exposed to hypoxic air – after just one month,... Read More | Comment
Upvote Story 3
Vitamin B12 is essential in the homocysteine, mitochondrial, muscle and hematopoietic metabolisms, and its effects on exercise tolerance and kinetics adjustments of oxygen consumption (V'O2p) in rest-to-exercise transition in COPD patients are unknown. This randomized, double-blind, controlled study aimed to verify a possible interaction between vitamin B12 supplementation and these outcomes. After recruiting 69 patients, 35 subjects with moderate-to-severe COPD were eligible and 32 patients... Read More | Comment