Anticipating the Future of the COVID-19 Pandemic

Anticipating the Future of the COVID-19 Pandemic

The initial instance of a severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection was observed in December 2019 in the city of Wuhan, China. Subsequently, the virus disseminated expeditiously across the globe,... read more

Omadacycline Treatment of Severe Pneumonia Complicated with ARDS During COVID-19

Omadacycline Treatment of Severe Pneumonia Complicated with ARDS During COVID-19

Metagenomic next-generation sequencing (mNGS) has a significant value in the diagnosis of Chlamydia psittaci infection. Timely treatment of omadacycline can improve prognosis and provide a promising new option for the treatment... read more

Sepsis Management: PIRO and MODS

Sepsis Management: PIRO and MODS

This book is unique in approaching multiple organ dysfunction syndrome (MODS) from the perspective of its pathophysiological mechanism, and addressing aspects that are overlooked in most of the available literature. Eminent... read more

Screening Tools for Sepsis Identification

Screening Tools for Sepsis Identification

The authors undertook a rapid review to determine the suitability of sepsis screening tools in the emergency setting with regard to sensitivity and specificity of sepsis diagnosis. The review recognized that there is currently... read more

COVID-19 Severity and 2-year Prevalence of Physical Symptoms

COVID-19 Severity and 2-year Prevalence of Physical Symptoms

Although the persistence of physical symptoms after SARS-CoV-2 infection is a major public health concern, evidence from large observational studies beyond one year post diagnosis remain scarce. We aimed to assess the prevalence... read more

Effect of Mechanical Ventilation Under Intubation on Respiratory Tract Change of Bacterial Count

Effect of Mechanical Ventilation Under Intubation on Respiratory Tract Change of Bacterial Count

Mechanical ventilation under intubation may cause dysregulation of lower respiratory microbiota in rats. The most common 'second strike' in mechanically ventilated patients is a pulmonary infection caused by the ease with... read more

Thrombocytopenia Severity in COVID-19 Patients with Epstein-Barr Virus

Thrombocytopenia Severity in COVID-19 Patients with Epstein-Barr Virus

This study aimed to investigate the prevalence of viral co-infections in hospitalized patients and their potential association with platelet count (PLT) during hospitalization. Additionally, the study explored the gender... read more

When Fear Takes Control: The Multidrug Resistance Story During Pandemics

When Fear Takes Control: The Multidrug Resistance Story During Pandemics

The COVID-19 pandemic was an unanticipated event which revealed our lack of preparedness for dealing with large numbers of infectious patients whilst maintaining excellent care quality. Notable problems arose with AMS... read more

Endotoxin Role in Septic Shock

Endotoxin Role in Septic Shock

Septic shock can be caused by a variety of mechanisms including direct effects of bacterial toxins such as endotoxin. Annually, approximately 5–7 million patients worldwide develop sepsis with very high endotoxin activity... read more

Simple Blood Test Indicating Sepsis Relapse

Simple Blood Test Indicating Sepsis Relapse

Sepsis is often not adequately diagnosed at the early stage when it could still be potentially avoidable. In this report, we describe the dramatic hematological changes found in the blood of a sepsis survivor just after discharge... read more

Levels of Intensive Care vs. In-Hospital Mortality in Patients Hospitalized for Sepsis Stratified by SOFA

Levels of Intensive Care vs. In-Hospital Mortality in Patients Hospitalized for Sepsis Stratified by SOFA

Patients hospitalized for sepsis with Sequential Organ Failure Assessment (SOFA) scores greater than or equal to 6 in the ICU or HDU had lower in-hospital mortality than those in the general ward, as did those with SOFA scores... read more

Enteral Citrulline Supplementation vs. Placebo in Mechanically Ventilated Patients

Enteral Citrulline Supplementation vs. Placebo in Mechanically Ventilated Patients

Among mechanically ventilated ICU patients without sepsis or septic shock, enteral L-citrulline administration did not result in a significant difference in SOFA score on day 7 compared to placebo. Of 120 randomized patients... read more

Acute Undifferentiated Fever with Thrombocytopenia: Clinical and Etiological Profile

Acute Undifferentiated Fever with Thrombocytopenia: Clinical and Etiological Profile

Prompt recognition and management of thrombocytopenia in acute undifferentiated fever are vital. Thrombocytopenia, along with organ dysfunction and shock, significantly influence patient outcomes. Tailored interventions based... read more

Microbial Endocrinology: Interkingdom Signaling in Infectious Disease and Health

Microbial Endocrinology: Interkingdom Signaling in Infectious Disease and Health

This new edition highlights the numerous advances made in the field of microbial endocrinology over the last five years. Prominent among these new topics featured is the emergence of the microbiota-gut-brain axis and the... read more