Can Early Cytokine Profile Discriminate Between GPB and GNB?

Can Early Cytokine Profile Discriminate Between GPB and GNB?

Sepsis is a principal cause of death in critical care units worldwide and consumes considerable healthcare resources. The aim of our study was to determine whether the early cytokine profile can discriminate between Gram-positive... read more

Difference in Sepsis Patients Outcomes Between First and Second-Hit Infections

Difference in Sepsis Patients Outcomes Between First and Second-Hit Infections

Our study identifies a fundamental difference in patient outcomes between first-hit and second-hit bacterial infections, which may be due to genetic, microbiological, immunological, and environmental factors. This finding... read more

Multicomponent Sepsis Transition Effect and Recovery Program After Sepsis

Multicomponent Sepsis Transition Effect and Recovery Program After Sepsis

In a multisite randomized clinical trial of patients hospitalized with sepsis, patients provided with a 30-day program using a nurse navigator to provide best practices for postsepsis care experienced a lower proportion of... read more

Differential Dynamics of Peripheral Immune Responses to Acute COVID-19 Infection in Older Adults

Differential Dynamics of Peripheral Immune Responses to Acute COVID-19 Infection in Older Adults

In this study, peripheral blood mononuclear cells from young and old patients with COVID-19 were examined phenotypically, transcriptionally and functionally to reveal age-, time- and severity-specific adaptations. Gene... read more

ABCDEF Bundle Implementation for ICU Patients During the COVID-19

ABCDEF Bundle Implementation for ICU Patients During the COVID-19

Regardless of COVID-19 infection status, implementation rates for the ABCDEF bundle, for each element individually and an ICU diary were extremely low for patients without and with COVID-19 infections during the pandemic.... read more

The Use of Different Sepsis Risk Stratification Tools Uncovers Different Mortality Risks

The Use of Different Sepsis Risk Stratification Tools Uncovers Different Mortality Risks

Our data suggest that the sepsis risk stratification tools currently utilized in emergency departments and on the general wards do not predict mortality adequately. This is illustrated by the disparity in mortality risk... read more

Neurological Complications After First Dose of COVID-19 Vaccines

Neurological Complications After First Dose of COVID-19 Vaccines

Emerging reports of rare neurological complications associated with COVID-19 infection and vaccinations are leading to regulatory, clinical and public health concerns. We undertook a self-controlled case series study to investigate... read more

CCSC Encourage Flu Shots Amid COVID-19 Spread

CCSC Encourage Flu Shots Amid COVID-19 Spread

The members of the Critical Care Societies Collaborative (CCSC), which includes the American Association of Critical-Care Nurses (AACN), American College of Chest Physicians (CHEST), American Thoracic Society (ATS), and Society... read more

Carbapenem Antibiotics for the Empiric Treatment of Nosocomial Pneumonia

Carbapenem Antibiotics for the Empiric Treatment of Nosocomial Pneumonia

Carbapenem-based empiric regimens were associated with lower mortality rates compared with non-carbapenems, largely driven by trials of ventilator-associated pneumonia (VAP). The mortality effect was not observed in trials... read more

Perioperative Dexmedetomidine on the Incidence of Postoperative Delirium

Perioperative Dexmedetomidine on the Incidence of Postoperative Delirium

Delirium occurs commonly following major non-cardiac and cardiac surgery and is associated with: postoperative mortality; postoperative neurocognitive dysfunction; increased length of hospital stay; and major postoperative... read more

Brain–lung Interactions and Mechanical Ventilation in Patients with Isolated Brain Injury

Brain–lung Interactions and Mechanical Ventilation in Patients with Isolated Brain Injury

During the last decade, experimental and clinical studies have demonstrated that isolated acute brain injury (ABI) may cause severe dysfunction of peripheral extracranial organs and systems. Of all potential target organs... read more

Short-term and Long-term Rates of Postacute Sequelae of COVID-19 Infection

Short-term and Long-term Rates of Postacute Sequelae of COVID-19 Infection

In this systematic review, we evaluated the temporal progression of clinical abnormalities experienced by patients who recovered from an infection with SARS-CoV-2, starting with a mean of 30 days post–acute illness and... read more

COVID-19 Handbook: Navigating the Future of Healthcare

COVID-19 Handbook: Navigating the Future of Healthcare

The COVID-19 Handbook: Navigating the Future of Healthcare provides factual, evidence-based information on the coronavirus disease 2019 (COVID-19) pandemic. Presented in a concise PDF format, this valuable COVID-19 resource... read more

Scripts for Subconjunctival Hemorrhage, Fainting and Syncope, and Viral Illness

Scripts for Subconjunctival Hemorrhage, Fainting and Syncope, and Viral Illness

Many parts of the ED encounter interfere with patient or family comprehension, not the least of which is the ED's noisy, hurried environment. But other factors affect what they understand and remember about the encounter—their... read more