High-Dose Dexamethasone vs. Tocilizumab in COVID-19 Pneumonia

High-Dose Dexamethasone vs. Tocilizumab in COVID-19 Pneumonia

Our study findings discourage the use of high doses of dexamethasone in the management of moderate to severe COVID-19 ARDS. The routine use of such high doses to mitigate the inflammatory cytokine storm in these patients... read more

Immunological Dysfunction Persists for 8 months Following Initial Mild-to-Moderate COVID-19 Infection

Immunological Dysfunction Persists for 8 months Following Initial Mild-to-Moderate COVID-19 Infection

A proportion of patients surviving acute coronavirus disease 2019 (COVID-19) infection develop post-acute COVID syndrome (long COVID (LC)) lasting longer than 12 weeks. Here, we studied individuals with LC compared to... read more

Retrospective Analysis of Chest X-ray Severity Scoring System of COVID-19 Pneumonia

Retrospective Analysis of Chest X-ray Severity Scoring System of COVID-19 Pneumonia

The research will be retrospective, and will include a review of medical history of all patients admitted in the COVID-19 ICU of the University hospital Osijek during 2020 and 2021. Associated comorbidity, hospital admission... read more

MIF But Not MIF-2 Recruits Inflammatory Macrophages in an Experimental Polymicrobial Sepsis Model

MIF But Not MIF-2 Recruits Inflammatory Macrophages in an Experimental Polymicrobial Sepsis Model

Excessive inflammation drives the progression from sepsis to septic shock. Macrophage migration inhibitory factor (MIF) is of interest because MIF promoter polymorphisms predict mortality in different infections, and anti-MIF... read more

Biomarker-guided Steroid Dosing in COVID-19 Pneumonia

Biomarker-guided Steroid Dosing in COVID-19 Pneumonia

Although corticosteroid administration has been associated with improved outcomes in severe COVID-19 pneumonia, their ideal use remains undefined with a "one size fits all" approach used, irrespective of the individual inflammatory... read more

Obesity, Inflammatory and Thrombotic Markers, and Major Clinical Outcomes in Critically Ill Patients with COVID-19 in the US

Obesity, Inflammatory and Thrombotic Markers, and Major Clinical Outcomes in Critically Ill Patients with COVID-19 in the US

In critically ill patients with COVID-19, higher BMI was not associated with death or thrombotic events but was associated with a greater risk of ARDS and AKI-RRT. The lack of an association between BMI and circulating... read more

A Rare of Case of COVID-19-Related Pericardial Effusion and Cardiac Tamponade

A Rare of Case of COVID-19-Related Pericardial Effusion and Cardiac Tamponade

Acute pericarditis involves inflammation of the pericardial sac, which is made of an inner mesothelial visceral layer that surrounds the heart. Normally, this layer produces ~50 mL of fluid to lubricate the heart and... read more

miR-221-5p-Mediated Downregulation of JNK2 Aggravates ALI

miR-221-5p-Mediated Downregulation of JNK2 Aggravates ALI

Sepsis and acute lung injury (ALI) are linked to mitochondrial dysfunction; however, the underlying mechanism remains elusive. We previously reported that c-Jun N-terminal protein kinase 2 (JNK2) promotes stress-induced mitophagy... read more

The Relationship Between Vitamin D and Asthma Exacerbation

The Relationship Between Vitamin D and Asthma Exacerbation

Asthma is a chronic airway inflammatory condition that affects millions of people worldwide. It presents with reversible bronchoconstriction that makes it difficult for patients to breathe. Asthma flare-ups have several triggers,... read more

WHO Issues Guidelines on the Treatment of Children with MIS Associated with COVID-19

WHO Issues Guidelines on the Treatment of Children with MIS Associated with COVID-19

WHO issued updated guidelines on the management of multisystem inflammatory syndrome (MIS) in children associated with COVID-19 (MIS-C). MIS-C is a rare but serious condition where children with COVID-19 develop inflammation... read more

Mortality and Clinical Characteristics of MIS-C Associated with COVID-19

Mortality and Clinical Characteristics of MIS-C Associated with COVID-19

The clinical presentation and severity of Multisystem Inflammatory Syndrome in Children associated with COVID-19 (MIS-C) is widespread and presents a very low mortality rate in high-income countries. This research describes... read more

Endothelial Glycocalyx Degradation Contributes to Metabolic Acidosis in Children After Cardiopulmonary Bypass Surgery

Endothelial Glycocalyx Degradation Contributes to Metabolic Acidosis in Children After Cardiopulmonary Bypass Surgery

Our data show that metabolic acidosis (increased strong ion gap) is associated with plasma concentration of heparan sulfate, a negatively charged glycosaminoglycan cleaved from the endothelial glycocalyx during cardiopulmonary... read more

The Use of Different Sepsis Risk Stratification Tools Uncovers Different Mortality Risks

The Use of Different Sepsis Risk Stratification Tools Uncovers Different Mortality Risks

Our data suggest that the sepsis risk stratification tools currently utilized in emergency departments and on the general wards do not predict mortality adequately. This is illustrated by the disparity in mortality risk... read more

Brain–lung Interactions and Mechanical Ventilation in Patients with Isolated Brain Injury

Brain–lung Interactions and Mechanical Ventilation in Patients with Isolated Brain Injury

During the last decade, experimental and clinical studies have demonstrated that isolated acute brain injury (ABI) may cause severe dysfunction of peripheral extracranial organs and systems. Of all potential target organs... read more