The Song of the Cell: An Exploration of Medicine and the New Human

The Song of the Cell: An Exploration of Medicine and the New Human

In the late 1600s, Mukherjee sets the stage for an extraordinary tale. It revolves around two notable individuals: Robert Hooke, a renowned English polymath, and Antonie van Leeuwenhoek, an eccentric Dutch cloth-merchant.... read more

The Ketamine Drive-Through

The Ketamine Drive-Through

Patients who present with unexplained urinary tract symptoms or laboratory abnormalities on tests for liver injury should be asked about exposure to ketamine. Patients who chronically use ketamine should also be screened... read more

Bayesian Reanalysis of the Standard vs. Accelerated Initiation of RRT in AKI Trial

Bayesian Reanalysis of the Standard vs. Accelerated Initiation of RRT in AKI Trial

Timing of initiation of kidney-replacement therapy (KRT) in critically ill patients remains controversial. The Standard versus Accelerated Initiation of Renal-Replacement Therapy (RRT) in Acute Kidney Injury (STARRT-AKI)... read more

The developing kidney: Perinatal aspects and relevance throughout life

The developing kidney: Perinatal aspects and relevance throughout life

Human perinatal nephrology is a very diverse field in medicine, shared—among others—between obstetricians, neonatologists and nephrologists. Extremely low birth weight infants, babies with growth restriction, and specific... read more

Subphenotypes of AKI in Adults

Subphenotypes of AKI in Adults

Subphenotyping may help reduce heterogeneity under the umbrella term of acute kidney injury (AKI). Despite challenges remain, the identification of AKI subphenotypes has opened the potential of AKI research focused on better... read more

Sepsis-Associated AKI Risks in the PICU

Sepsis-Associated AKI Risks in the PICU

In children with severe sepsis, the degree of hemodynamic support as measured by the VIS and the presence of fluid overload may identify patients at increased risk of developing severe acute kidney injury (AKI). Children... read more

Intraoperative Hypotension and AKI after Noncardiac Surgery in Infants and Children

Intraoperative Hypotension and AKI after Noncardiac Surgery in Infants and Children

In distinct contrast to adults, the authors did not find any association between intraoperative hypotension and postoperative renal injury. Avoiding short periods of hypotension should not be the clinician’s primary concern... read more

Kidney Imaging with Point-of-Care Doppler Ultrasonography

Kidney Imaging with Point-of-Care Doppler Ultrasonography

We read with great interest the article by Caroli et al., in which they meticulously discuss the role of imaging in elucidating both structural and functional aspects of kidney disease. Herein, we would like to briefly comment... read more

Acute Kidney Injury in Cirrhosis

Acute Kidney Injury in Cirrhosis

Novel biomarkers may assist in identification of acute tubular necrosis and persistent/severe acute kidney injury (AKI). Norepinephrine has been suggested to be inferior to terlipressin, with additional research required.... read more

Risk of Venous Thromboembolism in Patients by Albuminuria and Estimated GFR

Risk of Venous Thromboembolism in Patients by Albuminuria and Estimated GFR

Albuminuria increases the risk for VTE markedly in patients with normal eGFRs compared with those with lower eGFRs. 15,180 (2.2%) VTE events occurred during the study period. Both albuminuria and eGFR were independently associated... read more

Implications of Prevalent Noncardiac Disease in the Cardiac ICU

Implications of Prevalent Noncardiac Disease in the Cardiac ICU

Half of >1000 patients of admitted to the cardiac intensive care unit (ICU) at a major tertiary-care center over about 1 year also had acute respiratory failure, acute kidney injury, or sepsis. Those with lung or kidney... read more