The Effect of Early Sedation With Dexmedetomidine on Body Temperature in Critically Ill Patients

The Effect of Early Sedation With Dexmedetomidine on Body Temperature in Critically Ill Patients

Previous case series reported an association between dexmedetomidine use and hyperthermia. Temperature data have not been systematically reported in previous randomized controlled trials evaluating dexmedetomidine. Our... read more

Effect of Nurse-Led GDLPT on the Prognosis of Pneumonia in Sepsis Patients in the ICU

Effect of Nurse-Led GDLPT on the Prognosis of Pneumonia in Sepsis Patients in the ICU

Nurse-led goal-directed lung physical therapy (GDLPT) improved the outcomes of pneumonia in sepsis patients, and was particularly associated with shortened mechanical ventilation duration and ICU stay, and reduced ICU mortality... read more

Physiological dead space and alveolar ventilation in ventilated infants

Physiological dead space and alveolar ventilation in ventilated infants

Prematurely born infants with pulmonary disease have a higher dead space than term controls, which may influence the optimum level during volume-targeted ventilation. A prospective study of mechanically ventilated infants... read more

Causes and Timing of Death in Critically Ill COVID-19 Patients

Causes and Timing of Death in Critically Ill COVID-19 Patients

Mortality rate of critically ill COVID-19 patients is high, especially in those requiring invasive mechanical ventilation. However, the causes and the timing of death of patients admitted to the ICU for SARS-CoV-2 pneumonia... read more

SOFA Score Accuracy For Determining Mortality Of Severely Ill Patients With COVID-19 Pneumonia

SOFA Score Accuracy For Determining Mortality Of Severely Ill Patients With COVID-19 Pneumonia

The SOFA score possesses inadequate discriminant accuracy to be used for ventilator triage of COVID-19 patients. A better option is needed that incorporates variables specifically related to mortality in patients with COVID-19... read more

Innovations in ICU Ventilation

Innovations in ICU Ventilation

Many centuries ago, Socrates stated that "the secret of change is to focus all of your energy, not on fighting the old, but on building the new." Nowadays, we may relate his quote with the concept of innovation, which is... read more

Epidemiology and microbiology of ventilator-associated pneumonia in COVID-19 patients

Epidemiology and microbiology of ventilator-associated pneumonia in COVID-19 patients

The COVID-19 pandemic is responsible for many hospitalizations in intensive care units (ICU), with widespread use of invasive mechanical ventilation (IMV) which exposes patients to the risk of ventilator-associated pneumonia... read more

Is chloroquine or hydroxychloroquine useful in treating people with COVID-19, or in preventing infection in people who have been exposed to the virus?

Is chloroquine or hydroxychloroquine useful in treating people with COVID-19, or in preventing infection in people who have been exposed to the virus?

COVID-19 is an infectious respiratory disease caused by a coronavirus called SARS-CoV-2. If the infection becomes severe, people may need intensive care and support in hospital, including mechanical ventilation. Drugs... read more

Barotrauma in Mechanically-ventilated Patients with COVID-2019

Barotrauma in Mechanically-ventilated Patients with COVID-2019

Within the limits of a survey, patients with COVID-19 might be at high risk for barotrauma during invasive (and allegedly lung-protective) mechanical ventilation. The response rate was 38/61 (62%). The incidence of... read more

COVID-19 and VILI: Mechanical Power Measurement

COVID-19 and VILI: Mechanical Power Measurement

The COVID-19 pandemic has increased the need for a bedside tool for lung mechanics assessment and ventilator-induced lung injury (VILI) monitoring. Mechanical power is a unifying concept including all the components which... read more

Nebulised heparin for patients with or at risk of ARDS

Nebulised heparin for patients with or at risk of ARDS

In patients with or at risk of acute respiratory distress syndrome (ARDS), nebulised heparin did not improve self-reported performance of daily physical activities, but was well tolerated and exploratory outcomes suggest... read more

Effectiveness of Bundle Interventions on ICU Delirium

Effectiveness of Bundle Interventions on ICU Delirium

This meta-analysis fails to support that bundle interventions are effective in reducing ICU delirium prevalence and duration, but supports that bundle interventions are effective in reducing the proportion of patient-days... read more

Basics of Mechanical Ventilation

Basics of Mechanical Ventilation

This book is a practical and easily understandable guide for mechanical ventilation. With a focus on the basics, this text begins with a detailed account of the mechanisms of spontaneous breathing as a reference point to... read more

Colchicine, the only effective oral medication for treating non-hospitalized COVID-19 patients

Colchicine, the only effective oral medication for treating non-hospitalized COVID-19 patients

The Montreal Heart Institute announced COLCORONA clinical trial has provided clinically persuasive results of colchicine's efficacy to treat COVID-19. The study results show that colchicine reduces the risk of death or... read more