Decreased Intestinal Microbiome Diversity in Pediatric Sepsis

Decreased Intestinal Microbiome Diversity in Pediatric Sepsis

Intestinal dysbiosis was associated with altered short-chain fatty acid metabolites in children with sepsis, but these findings were not linked directly to mitochondrial or immunologic changes. More detailed mechanistic studies... read more

Should fecal microbial transplantation be used in the ICU?

Should fecal microbial transplantation be used in the ICU?

FMT has become an attractive option to mitigate multiple organ dysfunction in the ICU. This article discusses the physiology, rationale, early experience, and expectations for such therapy in the critically ill patient. The... read more

Evidence Backs Giving Probiotics with Antibiotics

Evidence Backs Giving Probiotics with Antibiotics

So much of what we're told to do calls for sweeping practice changes or titanic additions to our routine approach. My own articles have advocated for tremendous shifts in typical techniques, and one need not look far to find... read more

Meet the trillions of viruses that make up your virome

Meet the trillions of viruses that make up your virome

If you think you don’t have viruses, think again. It may be hard to fathom, but the human body is occupied by large collections of microorganisms, commonly referred to as our microbiome, that have evolved with us since... read more

I Contain Multitudes: The Microbes Within Us and a Grander View of Life

I Contain Multitudes: The Microbes Within Us and a Grander View of Life

Joining the ranks of popular science classics like The Botany of Desire and The Selfish Gene, a groundbreaking, wondrously informative, and vastly entertaining examination of the most significant revolution in biology since... read more

Nutrition in Surgery and Critical Care

Nutrition in Surgery and Critical Care

DCRI Perioperative Nutrition focuses on the study of hospital-based treatments to improve preparation and recovery from surgery, major illness, and critical care. We put real science into improving patients' lives with interventions... read more

Admission to the ICU is Associated With Changes in the Oral Mycobiome

Admission to the ICU is Associated With Changes in the Oral Mycobiome

A prospective exploratory study was conducted to characterize the oral mycobiome at baseline and determine whether changes occur after admission to the intensive care unit (ICU). We found that ICU admission is associated... read more

Lung Microbiome: Key to Respiratory Ills?

Lung Microbiome: Key to Respiratory Ills?

Recently, JAMA discussed this research and its potential clinical applications with 2 experts on the front lines, Jack Gilbert, PhD, a microbial ecologist at the University of Chicago and director of its new Microbiome Center... read more

Disruption of the microbiota across multiple body sites in critically ill children

Disruption of the microbiota across multiple body sites in critically ill children

Microbiota in critically ill children differs sharply from the microbiota of healthy children and adults. Acknowledgement of dysbiosis associated with critical illness could provide opportunities to modulate the microbiota... read more