Thrombocytopenia and Platelet Transfusions in ICU Patients

Thrombocytopenia and Platelet Transfusions in ICU Patients

In this international prospective cohort study of acutely admitted adult ICU patients, we found that 43% had thrombocytopenia; 23% at ICU admission and 20% developed it during ICU stay. Patients with thrombocytopenia... read more

COVID-19-associated Sepsis: Incidence and Mortality

COVID-19-associated Sepsis: Incidence and Mortality

In this retrospective cohort study of hospitalized adults, SARS-CoV-2 accounted for approximately 1 in 6 cases of sepsis during the first 33 months of the COVID-19 pandemic. In-hospital mortality rates for SARS-CoV-2–associated... read more

ECLS in Infarct-Related Cardiogenic Shock

ECLS in Infarct-Related Cardiogenic Shock

In patients with acute myocardial infarction complicated by cardiogenic shock with planned early revascularization, the risk of death from any cause at the 30-day follow-up was not lower among the patients who received ECLS... read more

Levels of Intensive Care vs. In-Hospital Mortality in Patients Hospitalized for Sepsis Stratified by SOFA

Levels of Intensive Care vs. In-Hospital Mortality in Patients Hospitalized for Sepsis Stratified by SOFA

Patients hospitalized for sepsis with Sequential Organ Failure Assessment (SOFA) scores greater than or equal to 6 in the ICU or HDU had lower in-hospital mortality than those in the general ward, as did those with SOFA scores... read more

Tight Blood-Glucose Control without Early Parenteral Nutrition in the ICU

Tight Blood-Glucose Control without Early Parenteral Nutrition in the ICU

In critically ill patients who were not receiving early parenteral nutrition, tight glucose control did not affect the length of time that ICU care was needed or mortality. Of 9,230 patients who underwent randomization,... read more

Reducing Mortality in Critically Ill Patients

Reducing Mortality in Critically Ill Patients

This book describes the techniques, strategies, and drugs that have been demonstrated by multicenter randomized trials to influence survival in critically ill patients, defined as those who have acute failure of at least... read more

The impact of diabetes mellitus on morbidity and mortality in patients with COVID-19

The impact of diabetes mellitus on morbidity and mortality in patients with COVID-19

During the COVID-19 pandemic, healthcare delivery was affected in various ways. For example, acute and chronic cardiovascular diseases (CVDs) and events were less frequently observed in hospitals, both because public health... read more

Septic Shock Developing Later During Hospital Stay Associated with Higher Mortality

Septic Shock Developing Later During Hospital Stay Associated with Higher Mortality

In-hospital mortality continued to rise as admission-shock-onset-time increased in patients with septic shock. No clear dichotomization between early and late septic shock could be ascertained, and this categorization may... read more

Etomidate, Adrenal Insufficiency and Mortality Associated with Severity of Illness

Etomidate, Adrenal Insufficiency and Mortality Associated with Severity of Illness

Whereas etomidate causes adrenal insufficiency, it was not shown to increase mortality in many analyzed here in ICU settings. However, etomidate associated relative mortality rates increased progressively and correlated with... read more

Mental Health Morbidity Among Caregivers

Mental Health Morbidity Among Caregivers

While much of the research on post-ICU mental health morbidity has focused upon the survivors themselves, emerging data shows that caregivers of ICU patients are similarly impacted. The collective sequelae experienced... read more

New-onset Atrial Fibrillation in the ICU

New-onset Atrial Fibrillation in the ICU

Patients who develop new-onset atrial fibrillation (NOAF) during an ICU admission are at a higher risk of in-hospital death and readmission to hospital with AF, heart failure, and stroke than those who do not. Using the... read more

Sepsis Protocols to Reduce Mortality in Resource-restricted Settings

Sepsis Protocols to Reduce Mortality in Resource-restricted Settings

Simplified sepsis protocols are essential to improving sepsis-related mortality rates in resource-restricted settings, but adequate training of clinicians and modified protocols are necessary for successful implementation. Six... read more

Lower vs. Higher Oxygenation Targets in ICU Patients with Severe Hypoxemia

Lower vs. Higher Oxygenation Targets in ICU Patients with Severe Hypoxemia

Among adult ICU patients with severe hypoxemia, a lower oxygenation target (8 kPa) did not improve survival or HRQoL at 1 year as compared to a higher oxygenation target (12 kPa). We obtained 1‑year vital status for... read more

Multiple Organ Dysfunction in Older Major Trauma Critical Care Patients

Multiple Organ Dysfunction in Older Major Trauma Critical Care Patients

Frailty rather than chronological age appears to drive multiple organ dysfunction syndrome (MODS) development, recovery, and outcome in older cohorts. Early identification of frailty after trauma may help to predict MODS... read more