ECMO for COVID-19

ECMO for COVID-19

Mortality after ECMO for patients with COVID-19 worsened during 2020. These findings inform the role of extracorporeal membrane oxygenation (ECMO) in COVID-19 for patients, clinicians, and policy makers. In 2020, 4,812... read more

Higher vs. Lower PEEP in ARDS Patients

Higher vs. Lower PEEP in ARDS Patients

In our meta-analysis of RCTs, higher positive end-expiratory pressure (PEEP), compared with lower PEEP, was not associated with mortality in patients without acute respiratory distress syndrome (ARDS) receiving invasive mechanical... read more

COVID-19 and Anticoagulation: Full Dose or Prophylactic Dose?

COVID-19 and Anticoagulation: Full Dose or Prophylactic Dose?

In CRITICALLY ILL patients with COVID-19, an initial strategy of therapeutic-dose anticoagulation is not associated with a greater probability of survival to hospital discharge or a greater number of days free of cardiovascular... read more

Use of Bivalirudin for Anticoagulation in Pediatric ECMO

Use of Bivalirudin for Anticoagulation in Pediatric ECMO

This study describes the use of bivalirudin in children on extracorporeal membrane oxygenation (ECMO). Pediatric patients receiving bivalirudin were compared to patients receiving heparin as the anticoagulant on ECMO. Data... read more

Expanding ECMO Cannulation Strategies in Neonatal Respiratory Failure

Expanding ECMO Cannulation Strategies in Neonatal Respiratory Failure

Infants with refractory respiratory failure who require extracorporeal membrane oxygenation (ECMO) have traditionally been cannulated via the venoarterial route or by using a dual-lumen venovenous cannula in the right internal... read more

Adaptive Randomized Controlled Trial of Non-invasive Respiratory Strategies in ARF Patients with COVID-19

Adaptive Randomized Controlled Trial of Non-invasive Respiratory Strategies in ARF Patients with COVID-19

Continuous positive airway pressure (CPAP), compared with conventional oxygen therapy, reduced the composite outcome of intubation or death within 30 days of randomisation in hospitalized adults with acute respiratory failure... read more

Sedation Practices and Characteristics of Ventilated Patients

Sedation Practices and Characteristics of Ventilated Patients

Patients on mechanical ventilator experience anxiety and physiological stress. Sedating them can help those patients to cope up with ET tube, to bear all the interventions, for accessing adequate oxygenation and above... read more

A Rational Approach on the use of ECMO in Severe Hypoxemia

A Rational Approach on the use of ECMO in Severe Hypoxemia

Veno-venous extracorporeal membrane oxygenation (ECMO) is a helpful intervention in patients with severe refractory hypoxemia either because mechanical ventilation cannot ensure adequate oxygenation or because lung protective... read more

Oxygen Therapy in COVID-19 Patients: The Role of HFNC and CPAP

Oxygen Therapy in COVID-19 Patients: The Role of HFNC and CPAP

Oxygen therapy and non-invasive ventilation in COVID-19 should be based on pathophysiological changes and a step-by-step approach should be adopted in choosing the right therapeutic strategy for each patient. Continuous... read more

Aerosolised Surfactant Trial for Preterm Infants with RDS

Aerosolised Surfactant Trial for Preterm Infants with RDS

The AeroFact system can safely deliver aerosolised surfactant to preterm infants with respiratory distress syndrome (RDS) who are on nasal continuous positive airway pressure (nCPAP). 10 infants were enrolled in part 1... read more

Therapeutic vs. Prophylactic Anticoagulation for COVID-19 Patients with Elevated D-dimer Concentration

Therapeutic vs. Prophylactic Anticoagulation for COVID-19 Patients with Elevated D-dimer Concentration

In patients hospitalised with COVID-19 and elevated D-dimer concentration, in-hospital therapeutic anticoagulation with rivaroxaban or enoxaparin followed by rivaroxaban to day 30 did not improve clinical outcomes and increased... read more

Lactate = LactHATE

Lactate = LactHATE

Like many others who attended SMACC earlier this year I returned home dazed and confused about the significance of lactate in the septic patient. So like any good (aspiring to be) evidence-based medicine practitioner,... read more

Severity of Hypoxemia may Explain Indeterminate Results in Pediatric Trials of iNO

Severity of Hypoxemia may Explain Indeterminate Results in Pediatric Trials of iNO

Inhaled nitric oxide (iNO) is used for refractory hypoxemia in acute respiratory distress syndrome (ARDS) via vasodilation of pulmonary arterioles to ventilated alveoli, particularly in pediatrics. However, iNO has not affected... read more

COVID-19 ARDS has higher EVLWi and PVPI values than non-COVID-19 ARDS

COVID-19 ARDS has higher EVLWi and PVPI values than non-COVID-19 ARDS

Compared to acute respiratory distress syndrome (ARDS) patients without COVID-19, patients with COVID-19 had similar lung mechanics, but higher extravascular lung water index (EVLWi) and pulmonary vascular permeability index... read more