Tag: procalcitonin

Upvote Story 8
The combination of PCT and CRP or presepsin alone improves the accuracy of diagnosis of neonatal sepsis. However, further studies are required to confirm these findings. A total of 28 studies enrolling 2661 patients were included in our meta-analysis. The pooled sensitivity of CRP (0.71 (0.63, 0.78)) was weaker than that of PCT (0.85 (0.79, 0.89)), PCT + CRP (0.91 (0.84, 0.95)) and presepsin (0.94 (0.80, 0.99))... Read More | Comment
Upvote Story 7
Although the impact of PCT guidance on total healthcare-related costs during the initial hospitalisation episode is likely negligible, the lower in-hospital mortality may lead to a non-significant increase in costs over a one-year time horizon. However, since uncertainty remains, it is recommended to investigate the long-term cost-effectiveness of PCT guidance, from a societal perspective, in different countries and settings. A trial-based analysis was performed to... Read More | Comment
Upvote Story 5
Biomarkers represent an essential tool for identification of patients developing infection and to determine their clinical severity. Procalcitonin (PCT) levels appeared to be correlated with the development of severe bacterial infections. Thus, PCT systematic use has been proposed as part of the diagnostic tools and for monitoring treatment duration, but not all of the potential benefits and limitations of PCT have been investigated. We retrospectively... Read More | Comment
Upvote Story 4
The provision of procalcitonin assay results, along with instructions on their interpretation, to emergency department and hospital-based clinicians did not result in less use of antibiotics than did usual care among patients with suspected lower respiratory tract infection. In 14 U.S. hospitals with high adherence to quality measures for the treatment of pneumonia, we provided guidance for clinicians about national clinical practice recommendations for the... Read More | Comment
Upvote Story 16
In the Procalcitonin Antibiotic Consensus Trial (ProACT), the use of a procalcitonin-guided antibiotic prescription guideline did not result in less exposure to antibiotics than did usual care among patients presenting to the emergency department (ED) with suspected lower respiratory tract infection. Overuse of antibiotics is common in infections of the lower respiratory tract, where bacterial and viral infections manifest similarly. Procalcitonin is a peptide with... Read More | Comment