Procalcitonin in the ED: The evidence

Procalcitonin in the ED: The evidence

Is procalcitonin of any value in the emergency department? Considering that procalcitonin testing is not available in any of my hospitals, I have never been all that interested in this question. But Swami requested a procalcitonin... read more

Et Tu, Calcium?

Et Tu, Calcium?

We know our core medications for ACLS (epinephrine, amiodarone, lidocaine) but what is the role of other medications, like calcium? We know calcium can be used in the non-ACLS setting for hyperkalemia to prevent or treat... read more

Procalcitonin-guided Antibiotic Treatment Effect on Mortality in Acute Respiratory Infections

Procalcitonin-guided Antibiotic Treatment Effect on Mortality in Acute Respiratory Infections

Use of procalcitonin to guide antibiotic treatment in patients with acute respiratory infections reduces antibiotic exposure and side-effects, and improves survival. Widespread implementation of procalcitonin protocols... read more

Procalcitonin-Guided Use of Antibiotics for Lower Respiratory Tract Infection

Procalcitonin-Guided Use of Antibiotics for Lower Respiratory Tract Infection

The provision of procalcitonin assay results, along with instructions on their interpretation, to emergency department and hospital-based clinicians did not result in less use of antibiotics than did usual care among patients... read more

Comparison of Diagnostic Accuracy Among Procalcitonin, C-reactive protein, and Interleukin 6 for Blood Culture Positivity in General ICU Patients

Comparison of Diagnostic Accuracy Among Procalcitonin, C-reactive protein, and Interleukin 6 for Blood Culture Positivity in General ICU Patients

Despite various technological advances, it still usually takes at least 24 to 48 h to obtain a blood culture result. The subsequent delays in diagnosis and treatment of infection can negatively impact care in the intensive... read more

Procalcitonin does not curb antibiotic use for lower respiratory tract infection

Procalcitonin does not curb antibiotic use for lower respiratory tract infection

In the Procalcitonin Antibiotic Consensus Trial (ProACT), the use of a procalcitonin-guided antibiotic prescription guideline did not result in less exposure to antibiotics than did usual care among patients presenting to... read more

Procalcitonin Reduces Antibiotic Use with No Negative Outcomes

Procalcitonin Reduces Antibiotic Use with No Negative Outcomes

The elderly patient presenting to the ED with nonspecific symptoms remains a diagnostic and therapeutic challenge. Often, these patients arrive with general complaints ranging from altered mental status to weakness, subjective... read more

The combination of procalcitonin and C-reactive protein or presepsin alone improves the accuracy of diagnosis of neonatal sepsis

The combination of procalcitonin and C-reactive protein or presepsin alone improves the accuracy of diagnosis of neonatal sepsis

The combination of PCT and CRP or presepsin alone improves the accuracy of diagnosis of neonatal sepsis. However, further studies are required to confirm these findings. A total of 28 studies enrolling 2661 patients were... read more

Cost-effectiveness of Procalcitonin Testing to Guide Antibiotic Treatment Duration in Critically Ill Patients

Cost-effectiveness of Procalcitonin Testing to Guide Antibiotic Treatment Duration in Critically Ill Patients

Although the impact of PCT guidance on total healthcare-related costs during the initial hospitalisation episode is likely negligible, the lower in-hospital mortality may lead to a non-significant increase in costs over a... read more

Comparison between procalcitonin and C-reactive protein to predict blood culture results in ICU patients

Comparison between procalcitonin and C-reactive protein to predict blood culture results in ICU patients

Biomarkers represent an essential tool for identification of patients developing infection and to determine their clinical severity. Procalcitonin (PCT) levels appeared to be correlated with the development of severe bacterial... read more