Sepsis and Septic Shock: An Issue of Critical Care Clinics

Sepsis and Septic Shock: An Issue of Critical Care Clinics

Shock is caused by the decreased flow of blood to the body tissues due to circulatory system related problems. Sepsis refers to a life-threatening condition where the body causes injury to its own organs and tissues in response... read more

Sepsis: Methods and Protocols

Sepsis: Methods and Protocols

This detailed volume presents a variety of animal models that are commonly used to study sepsis and some key procedures to measure specific disease outcomes. The chapters describe well-established surgical and nonsurgical... read more

Sepsis Protocols to Reduce Mortality in Resource-restricted Settings

Sepsis Protocols to Reduce Mortality in Resource-restricted Settings

Simplified sepsis protocols are essential to improving sepsis-related mortality rates in resource-restricted settings, but adequate training of clinicians and modified protocols are necessary for successful implementation. Six... read more

Practical Issues Updates in Anesthesia and Intensive Care

Practical Issues Updates in Anesthesia and Intensive Care

This book describes the state of the art concerning some of the most hotly debated topics in anesthesia and intensive care and is at the same time intended to serve as a useful practical guide that will assist in improving... read more

Science and Practice of Pediatric Critical Care Medicine

Science and Practice of Pediatric Critical Care Medicine

The field of critical care medicine is in the midst of a dramatic change. Technological and scientific advances during the last decade have resulted in a fundamental change in the way we view disease processes, such as sepsis,... read more

Hemodynamic Management Challenges of Septic Shock

Hemodynamic Management Challenges of Septic Shock

Sepsis is one of the main causes of admission to the Intensive Care Unit (ICU). It is defined as a life-threatening organ dysfunction, caused by dysregulated host response to infection (Singer et al. 2016). Septic shock... read more

Sepsis is scurvy? Vitamin C, Thiamine, and Steroids

Sepsis is scurvy? Vitamin C, Thiamine, and Steroids

I have avoided commenting on vitamin C for sepsis, because commentary seemed rather unnecessary. The hype was obviously ridiculous. The chances of it helping were clearly low. The evidence of benefit was negligible. Others... read more

Septic Shock and Vasopressor Initiation: Why Earlier is Better

Septic Shock and Vasopressor Initiation: Why Earlier is Better

An overview of vasopressor management, current evidence and when to initiate vasopressor therapy for best possible patient outcome. Vasopressor management is a cornerstone in the haemodynamic management of septic shock... read more

ICM White Paper Proposes Infection Prevention Roadmap Integrating AMR and Sepsis

ICM White Paper Proposes Infection Prevention Roadmap Integrating AMR and Sepsis

The COVID-19 pandemic has put a spotlight on the devastating global health and societal implications an infection can have when there are no preventative interventions or treatment options available. Many countries and most... read more

Sepsis Hospitalization and Risk of Subsequent Cardiovascular Events in Adults

Sepsis Hospitalization and Risk of Subsequent Cardiovascular Events in Adults

Adult sepsis survivors experience an increased hazard of major cardiovascular events compared to survivors of a non-sepsis hospitalization. 254,241 adult sepsis survivors were matched to adult survivors of non-sepsis hospitalization... read more

Therapeutic Hyperthermia Associated with Improved Survival in Afebrile Critically Ill Patients with Sepsis

Therapeutic Hyperthermia Associated with Improved Survival in Afebrile Critically Ill Patients with Sepsis

Participants randomized to external forced-air warming did not have a difference in HLA-DR expression or IFN-γ production. In this pilot study, however, 28-day mortality was lower in the intervention group. Future research... read more

Arterial pH with Hemodynamic Response Association to Vasopressin in Patients with Septic Shock

Arterial pH with Hemodynamic Response Association to Vasopressin in Patients with Septic Shock

Compared with higher arterial pH, patients with septic shock and low arterial pH had lower odds of vasopressin response and higher catecholamine doses after vasopressin initiation. Similar to other vasopressors, the clinical... read more

Adult Sepsis Hospitalization and Risk of Subsequent Cardiovascular Events

Adult Sepsis Hospitalization and Risk of Subsequent Cardiovascular Events

Adult sepsis survivors experience an increased hazard of major cardiovascular events compared to survivors of a non-sepsis hospitalization. 254,241 adult sepsis survivors were matched to adult survivors of non-sepsis hospitalization... read more

Inflammatory and Immunosuppressive Responses to COVID-19 and Bacterial Sepsis

Inflammatory and Immunosuppressive Responses to COVID-19 and Bacterial Sepsis

Bacterial sepsis patients had early, severe inflammation, profound immune suppression, and life-threatening organ dysfunction that resolved over time; SARS-CoV-2 patients had less severe early inflammation and organ dysfunction... read more