Timing of Antibiotic Therapy in the ICU

Timing of Antibiotic Therapy in the ICU

Severe or life threatening infections are common among patients in the intensive care unit (ICU). Most infections in the ICU are bacterial or fungal in origin and require antimicrobial therapy for clinical resolution. Antibiotics... read more

Dynamic and Hybrid Configurations for ECMO

Dynamic and Hybrid Configurations for ECMO

Dynamic or hybrid configurations for extracorporeal membrane oxygenation (ECMO) are needed when patient physiology or clinical conditions change. Dynamic configurations included configurations converting from veno-arterial... read more

Epidemiology of Intravenous Immune Globulin in Septic Shock

Epidemiology of Intravenous Immune Globulin in Septic Shock

Intravenous immune globulin is used infrequently across the US in patients with septic shock. Regimens of IVIG in septic shock may be less intensive than those associated with a survival benefit in meta-analyses. Observed... read more

Higher ICU Sepsis Case Volume Associated with Significantly Lower Hospital Mortality

Higher ICU Sepsis Case Volume Associated with Significantly Lower Hospital Mortality

In this cohort study of 273,001 patients with sepsis at 231 ICUs in the UK, a higher annual sepsis case volume in the ICU was associated with significantly lower hospital mortality, and this association had no significant... read more

Factors Associated With Initiation of ECPR in the Pediatric Population

Factors Associated With Initiation of ECPR in the Pediatric Population

Although extracorporeal cardiopulmonary resuscitation (ECPR) is increasingly utilized in the pediatric critical care environment, our understanding regarding pediatric candidacy for ECPR remains unknown. Our objective... read more

ACEP Task Force on Septic Shock Should Replace the Surviving Sepsis Campaign

ACEP Task Force on Septic Shock Should Replace the Surviving Sepsis Campaign

The critical care community has long been plagued by a series of antiquated, overbearing guidelines created by the Surviving Sepsis Campaign (SSC). The campaign was originally sponsored by Eli Lilly and Edwards Life Sciences,... read more

Prior Exposure to Angiotensin II Receptor Blockers in Patients With Septic Shock to Individualize Mean Arterial Pressure Target?

Prior Exposure to Angiotensin II Receptor Blockers in Patients With Septic Shock to Individualize Mean Arterial Pressure Target?

Our results suggest that patients with septic shock and chronic hypertension treated with angiotensin II receptor blocker may benefit from a high mean arterial pressure target to reduce the risk of acute kidney injury occurrence. We... read more

The Association of Platelet Decrease Following CRRT Initiation and Increased Rates of Secondary Infections

The Association of Platelet Decrease Following CRRT Initiation and Increased Rates of Secondary Infections

Platelet count drop by greater than 40% following continuous renal replacement therapy (CRRT) initiation is associated with an increased risk of secondary infection, particularly in patients with thrombocytopenia at the time... read more

Adjuvant therapeutic plasma exchange in septic shock

Adjuvant therapeutic plasma exchange in septic shock

The hallmark of sepsis is a pathological host response to an infection that may lead to organ dysfunction, shock and high mortality. Besides numerous circulating mediators initiating inflammation, vascular barrier breakdown... read more

External Corroboration That Corticosteroids May Be Harmful to Septic Shock Endotype A Patients

External Corroboration That Corticosteroids May Be Harmful to Septic Shock Endotype A Patients

This exploratory analysis provides further evidence that corticosteroid exposure may be associated with increased mortality among septic shock endotype A patients. We previously reported gene expression-based endotypes... read more

Early prediction of impending septic shock in children using age-adjusted Sepsis-3 criteria

Early prediction of impending septic shock in children using age-adjusted Sepsis-3 criteria

Sepsis is a syndrome which afflicts both adults and children, with many disease courses and diverse outcomes. Understanding of sepsis pathophysiology has changed over time; the Sepsis-3 criteria define sepsis in adults as... read more

Factors Associated to ICU Mortality in Critically Ill Patients Infected with COVID-19 in Spain

Factors Associated to ICU Mortality in Critically Ill Patients Infected with COVID-19 in Spain

Older COVID-19 patients with higher APACHE II scores on admission, those who developed AKI grades II or III and/or septic shock during ICU stay had an increased risk-of-death. ICU mortality was 31%. A total of 663 patients... read more

VA-ECMO to Rescue Sepsis-induced Cardiogenic Shock

VA-ECMO to Rescue Sepsis-induced Cardiogenic Shock

Patients with sepsis-induced cardiomyopathy with cardiogenic shock have a high mortality. This study assessed venoarterial extracorporeal membrane oxygenation (VA-ECMO) support for sepsis-induced cardiogenic shock refractory... read more

Shedding Light on a Hidden Source of Septic Shock with POCUS

Shedding Light on a Hidden Source of Septic Shock with POCUS

Septic shock has a high mortality rate, estimated to be higher than 40% [1], increasing as time passes without appropriate treatment. Hence, correct diagnosis of the cause of sepsis is essential to provide correct antibiotic... read more