Alterations in qSOFA, SIRS, MEWS or NEWS Score Present in Half of Patients

Alterations in qSOFA, SIRS, MEWS or NEWS Score Present in Half of Patients

Almost half of patients with a suspected infection experience a change in the score of qSOFA, SIRS, MEWS and/or NEWS during ED stay. Approximately half of alterations were from a normal to an abnormal score and half vice... read more

Pressure Support vs. Spontaneous Ventilation during Anesthetic Emergence – Effect on Postoperative Atelectasis

Pressure Support vs. Spontaneous Ventilation during Anesthetic Emergence – Effect on Postoperative Atelectasis

The incidence of postoperative atelectasis was lower in patients undergoing either laparoscopic colectomy or robot-assisted prostatectomy who received pressure support ventilation during emergence from general anesthesia... read more

First-Pass Orotracheal Intubation: Video Laryngoscopy vs. Direct Laryngoscopy

First-Pass Orotracheal Intubation: Video Laryngoscopy vs. Direct Laryngoscopy

Among patients in the ICU requiring intubation, video laryngoscopy compared with direct laryngoscopy did not improve first-pass orotracheal intubation rates and was associated with higher rates of severe life-threatening... read more

Procalcitonin-guided Antibiotic Treatment Effect on Mortality in Acute Respiratory Infections

Procalcitonin-guided Antibiotic Treatment Effect on Mortality in Acute Respiratory Infections

Use of procalcitonin to guide antibiotic treatment in patients with acute respiratory infections reduces antibiotic exposure and side-effects, and improves survival. Widespread implementation of procalcitonin protocols... read more

Noninvasive Ventilation and Outcomes in Bronchiolitis

Noninvasive Ventilation and Outcomes in Bronchiolitis

In a large cohort of infants at children’s hospitals, noninvasive and invasive ventilation increased significantly from 2010 to 2018. Hospital-level noninvasive ventilation utilization was not associated with a reduction... read more

Identification of Biomarkers, New Treatments, and Vaccines for COVID-19

Identification of Biomarkers, New Treatments, and Vaccines for COVID-19

The novel coronavirus 2019 (COVID-19) has caused a serious global pandemic in just one year. Nearly every country and territory in the world has been affected by the virus. The virulence and infection rate of the virus are... read more

Burden of Post-Sepsis Morbidity Higher Than Previously Thought

Burden of Post-Sepsis Morbidity Higher Than Previously Thought

A recent cohort study published in JAMA based on data from 116,507 survivors of hospital-treated sepsis in Germany sheds light on the heavy burden of long-term effects of sepsis, the most severe complication of infections. The... read more

Recovery, Rehabilitation and Follow-up Services After Critical Illness

Recovery, Rehabilitation and Follow-up Services After Critical Illness

Overall, these data demonstrate a proliferation of recovery, follow-up and rehabilitation services for critically ill adults in the past decade across the UK, although service gaps remain suggesting further work is required... read more

Prevalence of Hepatopancreatic Injury in Patients with COVID-19

Prevalence of Hepatopancreatic Injury in Patients with COVID-19

COVID-19 can cause liver injury. Mortality, disease severity, and hospital length of stay are increased in COVID-19 patients with hepatopancreatic injury. Forty-five thousand three hundred sixty patients were included... read more

COVID-19 and Myocardial Infarction

COVID-19 and Myocardial Infarction

COVID-19 is a risk factor for myocardial infarction and stroke through self-controlled case series evaluation, a method that has been used to establish the risk of myocardial infarction associated with influenza infection. Regarding... read more

Oxygenation Responses Mechanisms to Proning and Recruitment in COVID-19 Pneumonia

Oxygenation Responses Mechanisms to Proning and Recruitment in COVID-19 Pneumonia

In unresolving COVID-19 pneumonia, the respiratory mechanics and the gas-exchange response to prone positioning and recruitment largely depend on the following two factors: perfusion dysregulation and the amount of consolidated... read more

The Pulmonary Artery Catheter: A Solution Still Looking For a Problem

The Pulmonary Artery Catheter: A Solution Still Looking For a Problem

In 1970, Jeremy Swan, William Ganz, and colleagues published their seminal paper “Catheterization of the heart in man with use of flow-directed balloon-tipped catheter”. Few devices in our specialty have generated more... read more

Serum Sodium and In-Hospital Mortality in Critically Ill Patients

Serum Sodium and In-Hospital Mortality in Critically Ill Patients

In this large multicenter observational cohort study of ICU patients, we aimed to assess the independent association of changes in serum sodium in the first 48 hours of ICU admission with in-hospital mortality for patients... read more

Aspirin is Linked with Increased Risk of Heart Failure

Aspirin is Linked with Increased Risk of Heart Failure

Aspirin use is associated with a 26% raised risk of heart failure in people with at least one predisposing factor for the condition. That’s the finding of a study published today in ESC Heart Failure, a journal of the European... read more