Tag: study
Difference in Sepsis Patients Outcomes Between First and Second-Hit Infections
Our study identifies a fundamental difference in patient outcomes between first-hit and second-hit bacterial infections, which may be due to genetic, microbiological, immunological, and environmental factors. This finding... read more
HIV and COVID-19 Increased Risk of Severe Outcomes
People living with HIV with detectable HIV viraemia, chronic comorbidities, and some subpopulations could be at increased risk of severe outcomes from COVID-19. These groups should be prioritised in clinical management and... read more
Impact of Tight Glucose Control on Circulating 3-hydroxybutyrate in Critically Ill Patients
Tight versus liberal glucose control in the context of early parenteral nutrition did not affect 3-hydroxybutyrate concentrations in critically ill patients. Hence, the protective effects of tight glucose control in this... read more
Multicomponent Sepsis Transition Effect and Recovery Program After Sepsis
In a multisite randomized clinical trial of patients hospitalized with sepsis, patients provided with a 30-day program using a nurse navigator to provide best practices for postsepsis care experienced a lower proportion of... read more
Early COVID-19 Treatment with SARS-CoV-2 Neutralizing Antibody Sotrovimab
Among high-risk patients with mild-to-moderate COVID-19, sotrovimab reduced the risk of disease progression. No safety signals were identified. The results of this interim analysis of COMET-ICE indicate that sotrovimab... read more
Differential Dynamics of Peripheral Immune Responses to Acute COVID-19 Infection in Older Adults
In this study, peripheral blood mononuclear cells from young and old patients with COVID-19 were examined phenotypically, transcriptionally and functionally to reveal age-, time- and severity-specific adaptations. Gene... read more
Risk of Death in Hospitalised COVID‐19 Patients Is Not Reduced by Azithromycin Treatment
The effect of antibiotics with potential antiviral and anti‐inflammatory properties are being investigated in clinical trials as treatment for COVID‐19. We are certain that risk of death in hospitalised COVID‐19... read more
ABCDEF Bundle Implementation for ICU Patients During the COVID-19
Regardless of COVID-19 infection status, implementation rates for the ABCDEF bundle, for each element individually and an ICU diary were extremely low for patients without and with COVID-19 infections during the pandemic.... read more
Impact on Mental, Physical and Cognitive functioning of a Critical care sTay during the COVID-19 pandemic
The ongoing pandemic could affect the duration, variety and severity of the mental, physical, and cognitive impairments intensive care unit (ICU) survivors and their families frequently present. We aim to determine the impact... read more
Neurological Complications After First Dose of COVID-19 Vaccines
Emerging reports of rare neurological complications associated with COVID-19 infection and vaccinations are leading to regulatory, clinical and public health concerns. We undertook a self-controlled case series study to investigate... read more
Prehospital FAST Reduces Admission Time and Treatment
The focused assessment with sonography in trauma (FAST) exam is an established trauma care diagnostic procedure. Ultrasound performed during prehospital care can improve early treatment and management of the patients. According... read more
COVID-19 and Critical Illness Neuropathy
We have described COVID patients in the ICU with critical illness neuropathy (CIP). COVID-related CIP could have implications for the functional recovery and rehabilitation strategies. Nerve conduction studies showed a... read more
Changes in Barriers to Implementing Early Mobilization in the ICU
This study was undertaken to investigate the rate of mobilization, defined as a rehabilitation level of sitting on the edge of a bed or higher, and its association with changes in barriers in the intensive care unit (ICU).... read more
Interhospital Transfer of COVID-19 Patients Treated with High-flow Nasal Oxygen Therapy
At the start of the COVID-19 pandemic, early intubation was recommended on the basis of worldwide observations of severe hypoxemia. However, some patients were ultimately able to benefit from high-flow nasal cannula (HFNC)... read more
