Impact of Marijuana on Venous Thromboembolic Events

Impact of Marijuana on Venous Thromboembolic Events

Tetrahydrocannabinoids (THC) exposure increases the risk of TEC in patients with trauma. Early identification and treatment for TEC is required to improve outcomes in this high-risk subset of trauma patients. We performed... read more

COVID-19 Antibody Seropositivity Longevity Analysis

COVID-19 Antibody Seropositivity Longevity Analysis

Seropositivity of IgG antibodies to both SARS-CoV-2 S and N-proteins followed a linear trend reaching approximately 90% positivity at 21 days post-index. The rate of N-protein seropositivity declined at a sharper rate,... read more

COVID-19 Infection Induces Long-lived Bone Marrow Plasma Cells

COVID-19 Infection Induces Long-lived Bone Marrow Plasma Cells

Population scale sweeps of viral pathogens, such as SARS-CoV-2, require high intensity testing for effective management. Here, we describe "Systematic Parallel Analysis of RNA coupled to Sequencing for Covid-19 screening"... read more

Percutaneous Ultrasound Guided Gastrostomy Tube Placement

Percutaneous Ultrasound Guided Gastrostomy Tube Placement

Percutaneous ultrasound guided gastrostomy (PUG) is similar in terms of complications to percutaneous gastrostomy tube (PRG) placement and a safe method for gastrostomy tube placement in the critically ill with the added... read more

Major Trauma Definition Using Different Revisions of the Abbreviated Injury Scale

Major Trauma Definition Using Different Revisions of the Abbreviated Injury Scale

Injury Severity Score (ISS) 08 ≥ 11 and ISS 15 ≥ 12 perform similarly to a threshold ISS 98 ≥ 16 for in-hospital mortality and ICU admission. This confirms studies evaluating mapped datasets, and is the... read more

d-dimer and Death in COVID-19 Patients

d-dimer and Death in COVID-19 Patients

In this multicenter cohort study of critically ill adults with COVID-19 admitted to ICUs across the United States, higher d-dimer was independently associated with a greater risk of death. The added value of d-dimer in... read more

Variation in Pediatric Palliative Care Allocation Among Critically Ill Children in the United States

Variation in Pediatric Palliative Care Allocation Among Critically Ill Children in the United States

Palliative care consultation for critically ill children in the United States is low. Palliative care utilization is increasing but considerable variation exists across institutions, suggesting inequity in palliative care... read more

Admission Hemoglobin Levels Are Associated With Functional Outcome in Spontaneous Intracerebral Hemorrhage

Admission Hemoglobin Levels Are Associated With Functional Outcome in Spontaneous Intracerebral Hemorrhage

Higher hemoglobin levels are associated with better outcome in intracerebral hemorrhage. Further research is needed to evaluate admission hemoglobin levels as both a therapeutic target and predictor of outcome. Our exposure... read more

Pharmacological principles guiding prolonged glucocorticoid treatment in ARDS

Pharmacological principles guiding prolonged glucocorticoid treatment in ARDS

Current literature addressing the pharmacological principles guiding glucocorticoid (GC) administration in ARDS is scant. This paucity of information may have led to the heterogeneity of treatment protocols and misinterpretation... read more

Checklist for Early Recognition and Treatment of Acute Illness and Injury

Checklist for Early Recognition and Treatment of Acute Illness and Injury

A quality-improvement intervention with remote simulation training to implement a decision support tool was associated with decreased nonadherence to daily care processes, shorter length of stay, and decreased mortality. The... read more

Virtual Reality Tailored to the Needs of Post-ICU Patients

Virtual Reality Tailored to the Needs of Post-ICU Patients

ICU-specific virtual reality appears safe and more immersive than 2D, implicating that ICU-specific virtual reality is feasible for clinical use. One should however be aware of simulator sickness-related symptoms. Future... read more

Randomised controlled trials in pre-hospital trauma

Randomised controlled trials in pre-hospital trauma

This mapping review has highlighted that evidence from trials in prehospital trauma is sparse and where trials have been completed, the reporting is generally poor and study designs sub-optimal. There is a continued need,... read more

Criteria for Selecting COVID-19 Patients for Lung Transplantation

Criteria for Selecting COVID-19 Patients for Lung Transplantation

In May 2020, a team led by thoracic surgeon Konrad Hoetzenecker of the Department of Surgery of MedUni Vienna and Vienna General Hospital performed a lung transplant on a 44-year-old patient who had been seriously ill with... read more

Delayed Strategies for RRT Initiation for Severe AKI

Delayed Strategies for RRT Initiation for Severe AKI

In severe acute kidney injury (AKI) patients with oliguria for more than 72 h or blood urea nitrogen concentration higher than 112 mg/dL and no severe complication that would mandate immediate RRT, longer postponing of renal... read more