Why COVID-19 Pneumonia is More Deadly than Typical Pneumonia

Why COVID-19 Pneumonia is More Deadly than Typical Pneumonia

Bacteria or viruses like influenza that cause pneumonia can spread across large regions of the lung within hours. In the modern intensive care unit, these bacteria or viruses are usually controlled either by antibiotics or... read more

Critical Care Management of Infectious Meningitis and Encephalitis

Critical Care Management of Infectious Meningitis and Encephalitis

Central nervous system (CNS) infections represent 2.9% of the infections encountered in the intensive care unit (ICU). Among them, infectious meningitis and encephalitis, regardless of their community or healthcare-associated... read more

Ketamine for PTSD Treatment

Ketamine for PTSD Treatment

Post-traumatic stress disorder (PTSD) continues to be a problematic psychiatric condition that can be difficult to treat. SSRIs are the first-line treatment, and they are the only pharmaceutical class approved – their use... read more

Delirium Prevalence and Risk Factors for Critically Ill COVID-19 Patients

Delirium Prevalence and Risk Factors for Critically Ill COVID-19 Patients

Acute brain dysfunction was highly prevalent and prolonged in critically ill patients with COVID-19. Benzodiazepine use and lack of family visitation were identified as modifiable risk factors for delirium, and thus these... read more

Use of a Machine Learning Model to Predict Iatrogenic Hypoglycemia

Use of a Machine Learning Model to Predict Iatrogenic Hypoglycemia

These findings suggest that iatrogenic hypoglycemia can be predicted in a short-term prediction horizon after each BG measurement during hospitalization. Further studies are needed to translate this model into a real-time... read more

Pulmonary Hypertension: ED Presentation, Evaluation, and Management

Pulmonary Hypertension: ED Presentation, Evaluation, and Management

Pulmonary hypertension (PH), characterized by increased pulmonary vascular resistance and pulmonary arterial pressure, is associated with significant morbidity and mortality. The disease is heterogenous, with varying demographics... read more

Adverse Events in the ICU During Bed-Bath Procedures

Adverse Events in the ICU During Bed-Bath Procedures

Serious adverse events were observed in one-half of patients and concerned one-fifth of nurses, confirming the need for caution. Further studies are needed to test systematic serious adverse event prevention strategies. The... read more

Mortality Among LVAD Recipients Ineligible for Clinical Trials

Mortality Among LVAD Recipients Ineligible for Clinical Trials

These findings suggest that while treatment for patients who are ineligible for left ventricular assist device (LVAD) trial inclusion should be weighed against medical management, more consideration could be given to designing... read more

Problems in care and avoidability of death after discharge from ICU

Problems in care and avoidability of death after discharge from ICU

The proportion of deaths in hospital with some degree of avoidability is higher in patients discharged from an ICU than reported in hospital-wide populations. Extrapolating our findings suggests around 550 probably avoidable... read more

Cost-effectiveness of Adrenaline for Out-of-Hospital Cardiac Arrest

Cost-effectiveness of Adrenaline for Out-of-Hospital Cardiac Arrest

Adrenaline was not cost-effective when only directly related costs and consequences are considered. However, incorporating the indirect economic effects associated with transplanted organs substantially alters cost-effectiveness,... read more

The Value of Decreasing the Duration of the Infectious Period of Severe ARDS COVID-19 Infection

The Value of Decreasing the Duration of the Infectious Period of Severe ARDS COVID-19 Infection

Finding medications or vaccines that may decrease the infectious period of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could potentially reduce transmission in the broader population. We developed a computational... read more

A Novel Negative Pressure-Flow Waveform to Ventilate Lungs for Normothermic Ex Vivo Lung Perfusion

A Novel Negative Pressure-Flow Waveform to Ventilate Lungs for Normothermic Ex Vivo Lung Perfusion

Ex vivo lung perfusion (EVLP) is increasingly used to treat and assess lungs before transplant. Minimizing ventilator induced lung injury (VILI) during EVLP is an important clinical need, and negative pressure ventilation... read more

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

The mRNA-1273 vaccine showed 94.1% efficacy at preventing COVID-19 illness, including severe disease. Aside from transient local and systemic reactions, no safety concerns were identified. The trial enrolled 30,420 volunteers... read more

The Evolving Armamentarium of COVID-19 Therapeutics

The Evolving Armamentarium of COVID-19 Therapeutics

Multiple repositories have been created for the vast scientific outpouring of COVID-19 research. The NIH regularly updates its treatment guidelines, which will be the primary reference for this review. To cut to the... read more