A Novel Coronavirus from Patients with Pneumonia in China

A Novel Coronavirus from Patients with Pneumonia in China

4 lower respiratory tract samples, including bronchoalveolar-lavage fluid, were collected from patients with pneumonia of unknown cause who were identified in Wuhan on December 21, 2019, or later and who had been present... read more

Effects of a Multimodal Program Including Simulation on Job Strain Among Nurses Working in ICUs

Effects of a Multimodal Program Including Simulation on Job Strain Among Nurses Working in ICUs

Among ICU nurses, an intervention that included education, role-play, and debriefing resulted in a lower prevalence of job strain at 6 months compared with nurses who did not undergo this program. Further research is... read more

Depth of Anesthesia in Children Undergoing Cardiac Surgery Under Extracorporeal Circulation

Depth of Anesthesia in Children Undergoing Cardiac Surgery Under Extracorporeal Circulation

In children undergoing cardiac surgery in our department, the use of sevoflurane-balanced anesthesia during cardiopulmonary bypass showed no superiority of inhalational agents over total intravenous anesthesia with opioids... read more

When Exercise Comes to the Hospital’s ICUs

When Exercise Comes to the Hospital’s ICUs

Even short hospital ICU stays can cause lasting problems for patients. Can early mobility and exercise help? Apna Kudchadkar still remembers the morning in 2010 that shaped the trajectory of her scientific research. She... read more

Approaches to EOL Decision-making For Patients Affected by Sepsis and ARDS

Approaches to EOL Decision-making For Patients Affected by Sepsis and ARDS

A Qualitative Study of Patients With Acute Respiratory Distress Syndrome (ARDS) and Sepsis and Their Surrogates. The purpose of this study was to develop hypotheses of patient and surrogate's rationale for decision-making. Patients... read more

Risk Factors for the Development of ARDS in Mechanically Ventilated Adults in Peru

Risk Factors for the Development of ARDS in Mechanically Ventilated Adults in Peru

In this study of mechanically ventilated patients, 31% of study participants had acute respiratory distress syndrome (ARDS) at some point during their ICU stay. Optimal lung-protective ventilation was not used in a majority... read more

Automated Anesthetic Management Outperforms Manual Control and May Have an Impact on Delayed Neurocognitive Recovery

Automated Anesthetic Management Outperforms Manual Control and May Have an Impact on Delayed Neurocognitive Recovery

Among older, non-frail patients undergoing moderate and high-risk noncardiac surgery, an automated anesthetic management using the combination of three independent closed-loop systems outperformed manual control and may have... read more

Impact of Levosimendan on Weaning from Peripheral VA-ECMO in ICU

Impact of Levosimendan on Weaning from Peripheral VA-ECMO in ICU

This study suggests that levosimendan might be associated with a beneficial effect on venoarterial extracorporeal membrane oxygenation (VA-ECMO) weaning in ICU patients. The difference in mortality among propensity-matched... read more

Activin Type II Receptor Blockade for Treatment of Muscle Depletion in COPD

Activin Type II Receptor Blockade for Treatment of Muscle Depletion in COPD

Blocking the action of negative muscle regulators through the activin type II receptors with bimagrumab treatment safely increased skeletal muscle mass but did not improve functional capacity in patients with COPD and low... read more

Prehospital On-scene Anesthetist Treating Severe TBI Patients is Associated with Lower Mortality and Better Neurological Outcome

Prehospital On-scene Anesthetist Treating Severe TBI Patients is Associated with Lower Mortality and Better Neurological Outcome

Patients with isolated traumatic brain injury (TBI) are likely to benefit from effective prehospital care to prevent secondary brain injury. Only a few studies have focused on the impact of advanced interventions in TBI... read more

Impact of Paralytic Agent on Postintubation Sedation

Impact of Paralytic Agent on Postintubation Sedation

The aim of this study was to evaluate the difference in the time to postintubation sedation between patients receiving etomidate and either succinylcholine or rocuronium in the prehospital setting. This study suggests... read more

Vitamin Treatment For Sepsis Fails In Large Trial

Vitamin Treatment For Sepsis Fails In Large Trial

Hope for an effective and inexpensive treatment for the deadly condition sepsis has dimmed following results of a major new study. Researchers had hoped that a simple treatment involving infusions of vitamin C, vitamin... read more

Effect of Stress Ulcer Prophylaxis on In-Hospital Mortality Among ICU Patients Receiving Invasive Mechanical Ventilation

Effect of Stress Ulcer Prophylaxis on In-Hospital Mortality Among ICU Patients Receiving Invasive Mechanical Ventilation

Among ICU patients requiring mechanical ventilation, a strategy of stress ulcer prophylaxis with use of proton pump inhibitors vs histamine-2 receptor blockers resulted in hospital mortality rates of 18.3% vs 17.5%, respectively,... read more

Study Suggests Benefits of Vitamin C for Severe Sepsis

Study Suggests Benefits of Vitamin C for Severe Sepsis

More than 1.7 million Americans develop sepsis every year and incidence of the condition is on the rise. In severe cases, widespread inflammation leads to multiorgan failure and death. Results of a new study hold... read more