Failure of Non-invasive Ventilation in Patients with Acute Lung Injury

Failure of Non-invasive Ventilation in Patients with Acute Lung Injury

A high failure rate of the initial non-invasive positive pressure ventilation (NIPPV) therapy has been observed in medical critically ill patients with acute lung injury (ALI). Unless the underlying shock, metabolic acidosis... read more

Predicting Outcome in Patients with Moderate to Severe TBI Using Electroencephalography

Predicting Outcome in Patients with Moderate to Severe TBI Using Electroencephalography

Multifactorial Random Forest models using quantitative electroencephalography (qEEG) features, clinical data, and radiological findings have potential to predict neurological outcome in patients with moderate to severe traumatic... read more

Acute Kidney Injury in Hematopoietic Stem Cell Transplantation

Acute Kidney Injury in Hematopoietic Stem Cell Transplantation

This review provides an update on the risk factors, causes, and treatment approaches to HSCT-associated acute kidney injury (AKI). Patients who undergo HSCT have many risk factors for developing AKI, including sepsis,... read more

Effect of Depth of Sedation in Older Patients Undergoing Hip Fracture Repair on Postoperative Delirium

Effect of Depth of Sedation in Older Patients Undergoing Hip Fracture Repair on Postoperative Delirium

In the primary analysis, limiting the level of sedation provided no significant benefit in reducing incident delirium. However, in a pre-specified subgroup analysis, lighter sedation levels benefitted reducing postoperative... read more

Evidence is stronger than you think: a meta-analysis of vitamin C use in patients with sepsis

Evidence is stronger than you think: a meta-analysis of vitamin C use in patients with sepsis

Despite varying degrees of statistical significance between the original studies, this meta-analysis reveals a positive correlation between incorporating vitamin C in the treatment of sepsis and favorable patient outcomes,... read more

Assessment of Variability in End-of-Life Care Delivery in ICUs in the United States

Assessment of Variability in End-of-Life Care Delivery in ICUs in the United States

This study suggests most decedents in the ICU avoid CPR at EOL, have family present at their bedside, and are closely assessed for pain. However, the delivery of EOL care varies widely among units in the United States, including... read more

Fentanyl Infusion Pharmacokinetics Variables in Obese and Nonobese Children

Fentanyl Infusion Pharmacokinetics Variables in Obese and Nonobese Children

The differences in total clearance (CLS) may increase less than proportional to weight in obese children greater than 6-year-olds, while volume of distribution at steady state increases more than proportional to weight in... read more

Tailoring Hypothermia Duration to Ischemia Duration Improve Outcome From Out-of-Hospital Cardiac Arrest

Tailoring Hypothermia Duration to Ischemia Duration Improve Outcome From Out-of-Hospital Cardiac Arrest

Although a larger hypothermia/ischemia ratio was associated with good functional outcome after out-of-hospital cardiac arrest in this cohort, this association is primarily driven by duration of time to return of spontaneous... read more

Climate Change, Global Warming, and Intensive Care

Climate Change, Global Warming, and Intensive Care

In the last five decades, human activities have resulted in the release of increasing quantities of carbon dioxide and other greenhouse gases, thus contributing to global climate change by additional heating of the atmosphere.... read more

Update to the Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) Protocol

Update to the Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) Protocol

The analyses described here are those necessary to answer the trial's primary question of whether combined treatment with vitamin C, thiamine and steroids is more effective than placebo in increasing days alive and free from... read more

Fresh Red Blood Cell Transfusions No More Beneficial Than Older Red Blood Cells

Fresh Red Blood Cell Transfusions No More Beneficial Than Older Red Blood Cells

Researchers have found that transfusions using fresh red blood cells—cells that have spent seven days or less in storage—are no more beneficial than older red blood cells in reducing the risk of organ failure or death... read more

Serum Ferritin Identifies Septic Patients with Macrophage Activation-like Syndrome

Serum Ferritin Identifies Septic Patients with Macrophage Activation-like Syndrome

A serum ferritin level above 4420 ng/ml identifies in a reliable and very specific way the septic patient with macrophage activation-like syndrome (MALS). Since the recent subgroup analysis indicated a survival benefit... read more

Modeling Cardiac Dysfunction Following Traumatic Hemorrhage Injury

Modeling Cardiac Dysfunction Following Traumatic Hemorrhage Injury

Cardiac dysfunction (CD) importantly contributes to mortality in trauma patients, who survive their initial injuries following successful hemostatic resuscitation. This poor outcome has been correlated with elevated biomarkers... read more

Hyperchloremia Is Associated With AKI in Patients With Subarachnoid Hemorrhage

Hyperchloremia Is Associated With AKI in Patients With Subarachnoid Hemorrhage

Critically ill patients with subarachnoid hemorrhage show a strong association between hyperchloremia and acute kidney injury as well as acute kidney injury and mortality. Of 1,267 patients included in this cohort, 16.7%... read more