Tag: study
Failure of Non-invasive Ventilation in Patients with Acute Lung Injury
A high failure rate of the initial non-invasive positive pressure ventilation (NIPPV) therapy has been observed in medical critically ill patients with acute lung injury (ALI). Unless the underlying shock, metabolic acidosis... read more
Predicting Outcome in Patients with Moderate to Severe TBI Using Electroencephalography
Multifactorial Random Forest models using quantitative electroencephalography (qEEG) features, clinical data, and radiological findings have potential to predict neurological outcome in patients with moderate to severe traumatic... read more
Acute Kidney Injury in Hematopoietic Stem Cell Transplantation
This review provides an update on the risk factors, causes, and treatment approaches to HSCT-associated acute kidney injury (AKI). Patients who undergo HSCT have many risk factors for developing AKI, including sepsis,... read more
Effect of Depth of Sedation in Older Patients Undergoing Hip Fracture Repair on Postoperative Delirium
In the primary analysis, limiting the level of sedation provided no significant benefit in reducing incident delirium. However, in a pre-specified subgroup analysis, lighter sedation levels benefitted reducing postoperative... read more
Evidence is stronger than you think: a meta-analysis of vitamin C use in patients with sepsis
Despite varying degrees of statistical significance between the original studies, this meta-analysis reveals a positive correlation between incorporating vitamin C in the treatment of sepsis and favorable patient outcomes,... read more
Assessment of Variability in End-of-Life Care Delivery in ICUs in the United States
This study suggests most decedents in the ICU avoid CPR at EOL, have family present at their bedside, and are closely assessed for pain. However, the delivery of EOL care varies widely among units in the United States, including... read more
Fentanyl Infusion Pharmacokinetics Variables in Obese and Nonobese Children
The differences in total clearance (CLS) may increase less than proportional to weight in obese children greater than 6-year-olds, while volume of distribution at steady state increases more than proportional to weight in... read more
Tailoring Hypothermia Duration to Ischemia Duration Improve Outcome From Out-of-Hospital Cardiac Arrest
Although a larger hypothermia/ischemia ratio was associated with good functional outcome after out-of-hospital cardiac arrest in this cohort, this association is primarily driven by duration of time to return of spontaneous... read more
Climate Change, Global Warming, and Intensive Care
In the last five decades, human activities have resulted in the release of increasing quantities of carbon dioxide and other greenhouse gases, thus contributing to global climate change by additional heating of the atmosphere.... read more
Update to the Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) Protocol
The analyses described here are those necessary to answer the trial's primary question of whether combined treatment with vitamin C, thiamine and steroids is more effective than placebo in increasing days alive and free from... read more
Fresh Red Blood Cell Transfusions No More Beneficial Than Older Red Blood Cells
Researchers have found that transfusions using fresh red blood cells—cells that have spent seven days or less in storage—are no more beneficial than older red blood cells in reducing the risk of organ failure or death... read more
Serum Ferritin Identifies Septic Patients with Macrophage Activation-like Syndrome
A serum ferritin level above 4420 ng/ml identifies in a reliable and very specific way the septic patient with macrophage activation-like syndrome (MALS). Since the recent subgroup analysis indicated a survival benefit... read more
Modeling Cardiac Dysfunction Following Traumatic Hemorrhage Injury
Cardiac dysfunction (CD) importantly contributes to mortality in trauma patients, who survive their initial injuries following successful hemostatic resuscitation. This poor outcome has been correlated with elevated biomarkers... read more
Hyperchloremia Is Associated With AKI in Patients With Subarachnoid Hemorrhage
Critically ill patients with subarachnoid hemorrhage show a strong association between hyperchloremia and acute kidney injury as well as acute kidney injury and mortality. Of 1,267 patients included in this cohort, 16.7%... read more