Postoperative Pulmonary Complications in the ENIGMA II Trial

Postoperative Pulmonary Complications in the ENIGMA II Trial

Respiratory complications remain among the most common and serious adverse outcomes of major surgery. In the Australian and New Zealand Audit of Surgical Mortality, postoperative pneumonia accounted for 44% of infective... read more

Sick Children Identification in Acute Care Settings

Sick Children Identification in Acute Care Settings

At the heart of every pediatric consultation is the clinician’s responsibility to determine ‘is this child sick?’ In pediatrics illustrative language communicates a clinical picture of the child before us. When... read more

Rising Mortality in COVID-19 Patients Supported With ECMO

Rising Mortality in COVID-19 Patients Supported With ECMO

We aimed to describe practice patterns and outcomes in patients with extracorporeal membrane oxygenation (ECMO) support throughout the coronavirus 2019 (COVID-19) pandemic, with the hypothesis that mortality would improve... read more

Ultrasound-Guided Infraclavicular Axillary Vein vs. Internal Jugular Vein Cannulation in Critically Ill Mechanically Ventilated Patients

Ultrasound-Guided Infraclavicular Axillary Vein vs. Internal Jugular Vein Cannulation in Critically Ill Mechanically Ventilated Patients

No difference was found between the real-time ultrasound-guided out-of-plane cannulation of the IJV and the infraclavicular real-time ultrasound-guided in-plane cannulation of the AXV. Both techniques are equally efficient... read more

Early evaluation of heart rate variability can predict the outcome of patients in the ICU

Early evaluation of heart rate variability can predict the outcome of patients in the ICU

The study evaluated the use of heart rate variability (HRV) to predict the outcome of patients in the ICU. HRV is a way to evaluate the cardiac effects of the autonomic nervous system, and a relation between HRV and outcome... read more

Acute Effects of Ketamine on ICP in Children With Severe TBI

Acute Effects of Ketamine on ICP in Children With Severe TBI

In this retrospective, exploratory study, intracranial pressure (ICP) did not increase following ketamine administration. In the setting of a guidelines-based protocol, ketamine was associated with a reduction in ICP during... read more

Baricitinib or Tocilizumab for Severe COVID-19 Treatment

Baricitinib or Tocilizumab for Severe COVID-19 Treatment

Pharmacologic treatment of COVID-19 has continued to evolve since the onset of the pandemic, and yet many questions remain about optimal treatment. Medicine strives to provide evidence-based guidance on treatments, but... read more

6 Days Higher-Dose Ivermectin vs. Placebo on Time to Sustained Recovery in COVID-19 Outpatients

6 Days Higher-Dose Ivermectin vs. Placebo on Time to Sustained Recovery in COVID-19 Outpatients

Among a largely vaccinated outpatient population with mild to moderate COVID-19, treatment with ivermectin, with a targeted maximum dose of 600 μg/kg daily for 6 days, compared with placebo was not shown to improve time... read more

The effect of a multi-faceted quality improvement program on paramedic intubation success in the critical care transport environment

The effect of a multi-faceted quality improvement program on paramedic intubation success in the critical care transport environment

A multi-faceted advanced airway management (AAM) quality improvement program (QIP) resulted in statistically significant increase in intubation first pass success rates (FPS) rates and a non-significant improvement in DASH-1A... read more

Improving Access to ECMO for OHCA

Improving Access to ECMO for OHCA

Mobile teams using transport accessibility frameworks and principles can significantly improve patient access for out-of-hospital cardiac arrest (OHCA) compared to in-hospital extracorporeal cardiopulmonary resuscitation... read more

Remote Ischemic Conditioning in Septic Shock

Remote Ischemic Conditioning in Septic Shock

The treatment known as RECO did not significantly reduce the severity of organ failure as measured by the mean daily SOFA (sequential organ failure assessment) score from the start of the study to day 4 in patients with septic... read more

Molnupiravir Improves Recovery Time in COVID-19 Patients at High Risk of Severe Outcomes

Molnupiravir Improves Recovery Time in COVID-19 Patients at High Risk of Severe Outcomes

This analysis of a large randomized trial involving people who are at high risk of experiencing severe outcomes from COVID-19 and who had been vaccinated against SARS-CoV-2 infection found that adding molnupiravir to usual... read more

Family Presence During Cardiac Arrest Resuscitation

Family Presence During Cardiac Arrest Resuscitation

This systematic review identified four key findings. Firstly, there was a lack of high-quality evidence on the impact of family presence during resuscitation on patient outcomes. Secondly, family members had varied... read more

Time from Infiltrate on Chest Radiograph to VV ECMO in COVID-19 Affects Mortality

Time from Infiltrate on Chest Radiograph to VV ECMO in COVID-19 Affects Mortality

Venovenous extracorporeal membrane oxygenation (VV ECMO) has been used to treat severe coronavirus disease 2019 (COVID-19) acute respiratory distress syndrome; however, patient selection criteria have evolved throughout the... read more