Evidence-Based Practice in Nursing & Healthcare

Evidence-Based Practice in Nursing & Healthcare

Enhance your clinical decision-making capabilities and improve patient outcomes through evidence-based practice. Develop the skills and knowledge you need to make evidence-based practice (EBP) an integral part of your clinical... read more

Outcomes of Critically Ill Patients Who Received Cardiopulmonary Resuscitation

Outcomes of Critically Ill Patients Who Received Cardiopulmonary Resuscitation

Although overall survival of ICU patients was 15.9%, patients requiring pressors and who experienced a CPA in an ICU were half as likely to survive to discharge and to be discharged home than patients not taking pressors.... read more

Teaching the Principles of Pediatric Critical Care to Non-Intensivists in Resource Limited Settings

Teaching the Principles of Pediatric Critical Care to Non-Intensivists in Resource Limited Settings

It is a dismal reality of global health that the vast majority of critically ill or injured children are found in regions of the world least equipped to care for them. Most of these severely ill or injured children are cared... read more

The Continuing Saga of Nurse Staffing

The Continuing Saga of Nurse Staffing

Registered nurses are the backbone of America's health systems, providing care and support to patients across the lifespan. Appropriate nurse staffing is critical to ensure safe and effective care for patients. Nurse staffing... read more

Hospital Variation in RRT for Sepsis in the United States

Hospital Variation in RRT for Sepsis in the United States

Use of renal replacement therapy (RRT) in sepsis varied widely among nationally sampled hospitals without associated differences in mortality. Improving renal replacement standards for the initiation of therapy for sepsis... read more

The Association Between Visiting Intensivists and ICU Outcomes

The Association Between Visiting Intensivists and ICU Outcomes

During a period of service reconfiguration, intensivists routinely rostered to work in one ICU worked in another of the hospital's four ICUs. "Home" intensivists were those who continued to work in their usual... read more

Optimizing Ceftolozane-tazobactam Dosage in Critically Ill Patients During Continuous Venovenous Hemodiafiltration

Optimizing Ceftolozane-tazobactam Dosage in Critically Ill Patients During Continuous Venovenous Hemodiafiltration

Ceftolozane-tazobactam (C/T), the combination of a new cephalosporin with a classic β-lactamase inhibitor, is currently considered the most active betalactam antibiotic against P. aeruginosa. Despite several case reports... read more

In-Hospital Cardiac Arrest

In-Hospital Cardiac Arrest

In-hospital cardiac arrest is common and associated with a high mortality rate. Despite this, in-hospital cardiac arrest has received little attention compared with other high-risk cardiovascular conditions, such as stroke,... read more

Oliguria and AKI in Critically Ill Children

Oliguria and AKI in Critically Ill Children

Nearly one in five critically ill children with acute kidney injury (AKI) do not experience increase in serum creatinine. These acute kidney injury events, which are only identified by urine output criteria, are associated... read more

TCR Activation Mimics CD127 low PD-1 high Phenotype and Functional Alterations of T Lymphocytes from Septic Shock Patients

TCR Activation Mimics CD127 low PD-1 high Phenotype and Functional Alterations of T Lymphocytes from Septic Shock Patients

The proportion of CD127lowPD-1high T cells in patients was increased compared with healthy volunteers, although no global CD127 regulation was observed. Our results suggest that TCR activation participates in the occurrence... read more

The Great Debate Between Balanced and Unbalanced Crystalloids Continues

The Great Debate Between Balanced and Unbalanced Crystalloids Continues

This meta-analysis contributes very little to the current discussion mainly because of the heterogeneity of included studies. The use of fluid type in different pathologies isn't really what we need, but rather tailored use... read more

Obesity Improves Short-term Survival in Sepsis

Obesity Improves Short-term Survival in Sepsis

In a large cohort study of 55,038 adults hospitalized with sepsis, short-term mortality (death or hospice) was lower in overweight and obese patients compared with those with normal body mass indices (both unadjusted and... read more

Neurally adjusted ventilatory assist decreases work of breathing during non-invasive ventilation in infants with severe bronchiolitis

Neurally adjusted ventilatory assist decreases work of breathing during non-invasive ventilation in infants with severe bronchiolitis

In this physiological study, we report an improvement of respiratory unloading by adding a second level of pressure with NAVA in infants with severe bronchiolitis. WOB decreased immediately after switching to NAVA, as reported... read more

The EXACT Protocol

The EXACT Protocol

The EXACT protocol: a multi-centre, single-blind, randomised, parallel-group, controlled trial to determine whether early oxygen titration improves survival to hospital discharge in adult OHCA patients. This study will determine... read more