Turn the Lights On!: A Physician’s Personal Journey from the Darkness of Traumatic Brain Injury (TBI) to Hope, Healing, and Recovery

Turn the Lights On!: A Physician’s Personal Journey from the Darkness of Traumatic Brain Injury (TBI) to Hope, Healing, and Recovery

Often misdiagnosed and misunderstood, traumatic brain injury (TBI) may be a life-altering event which can produce a wide range of symptoms affecting physical as well as psychological health. Indeed, all senses can be affected,... read more

Quetiapine Decreases Mortality and Improve Neurological Outcomes in Critically-ill TBI Patients

Quetiapine Decreases Mortality and Improve Neurological Outcomes in Critically-ill TBI Patients

Quetiapine may decrease mortality and improve neurological outcomes in critically-ill traumatic brain injury (TBI) patients. It has a dose-dependent effect to decrease intracranial pressure (ICP) and increase cerebral perfusion... read more

Tranexamic Acid in TBI – CRASH-3 Trial Treatment

Tranexamic Acid in TBI – CRASH-3 Trial Treatment

The CRASH-3 trial is a multi-centre, randomised, placebo-controlled trial of the effects of tranexamic acid on death and disability in patients with traumatic brain injury (TBI). Patients with reactive pupils and/or mild... read more

Safe Transfer of the Brain-injured Patient

Safe Transfer of the Brain-injured Patient

The document considers recent developments in the management of multiply-injured patients and those with acute ischaemic stroke. Whilst many of the principles of safe transfer are common to all seriously ill patients,... read more

Tranexamic Acid Has Nominal Benefit for TBI

Tranexamic Acid Has Nominal Benefit for TBI

Studies examining the use of tranexamic acid (TXA) inescapably seem to pit our rigorous methodological demons against our practical clinical angels. The CRASH-2 trial randomized 20,211 adult trauma patients presenting... read more

Beta-Blocker Therapy in Severe TBI

Beta-Blocker Therapy in Severe TBI

Propranolol decreases in-hospital mortality and improves long-term functional outcome in isolated severe Traumatic Brain Injury (TBI). This randomized trial speaks in favor of routine administration of beta-blocker therapy... read more

Prehospital On-scene Anesthetist Treating Severe TBI Patients is Associated with Lower Mortality and Better Neurological Outcome

Prehospital On-scene Anesthetist Treating Severe TBI Patients is Associated with Lower Mortality and Better Neurological Outcome

Patients with isolated traumatic brain injury (TBI) are likely to benefit from effective prehospital care to prevent secondary brain injury. Only a few studies have focused on the impact of advanced interventions in TBI... read more

Intracranial Pressure & Neuromonitoring XVI

Intracranial Pressure & Neuromonitoring XVI

This book introduces the latest advances relating to the pathophysiology, biophysics, monitoring and treatment of traumatic brain injury, hydrocephalus, and stroke presented at the 16th International Conference on Intracranial... read more

Fixing Hypernatremia: Acting Fast or Acting Slow?

Fixing Hypernatremia: Acting Fast or Acting Slow?

This is the largest adult cohort study focusing on the neurologic complications and mortality after hypernatremia correction in critically ill adults. There wasn't any evidence that rapid correction of hypernatremia was... read more

Guidelines for the Management of Severe TBI

Guidelines for the Management of Severe TBI

Often, the available evidence is not sufficient to generate guidelines addressing the most critical questions faced by clinicians and patients. Although there have been some major developments in severe traumatic brain... read more

Prognostic Value of Spreading Depolarizations in Patients With Severe TBI

Prognostic Value of Spreading Depolarizations in Patients With Severe TBI

In this cohort study of patients with acute brain trauma, spreading depolarizations were predominant but heterogeneous and independently associated with poor neurologic recovery. Monitoring the occurrence of spreading depolarizations... read more

Quantitative EEG for Detection of Brain Ischemia

Quantitative EEG for Detection of Brain Ischemia

Electroencephalography (EEG) is a very promising tool for monitoring brain function in real-time in the ICU. There are characteristic changes that occur on EEG in response to brain ischemia, correlating with CBF and brain... read more

New Hope for Concussions TBI & PTSD

New Hope for Concussions TBI & PTSD

Dr. Larry Komer and Joan Chandler Komer offer new hope to those with brain injuries. Millions of people of all ages experience concussions. Many others have a more serious event known as a traumatic brain injury. Battlefield... read more

Prehospital Rapid Sequence Intubation Improves Functional Outcome for Patients with Severe TBI

Prehospital Rapid Sequence Intubation Improves Functional Outcome for Patients with Severe TBI

In adults with severe traumatic brain injury (TBI), prehospital rapid sequence intubation by paramedics increases the rate of favorable neurologic outcome at 6 months compared with intubation in the hospital. A total of... read more