Tag: treatment

Upvote Story 4
With the approval and release of angiotensin II, a new vasoactive agent is now available to utilize in these patients. Overall, the treatment for vasodilatory shock should not be a one-size fits all approach and should be individualized to each patient. A multimodal approach, integrating angiotensin II as a noncatecholamine option should be considered for patients presenting with this disease state. The Angiotensin II for... Read More | Comment
Upvote Story 5
In 2014, the Canadian Task Force on Preventive Health Care recommended against the prostate-specific antigen (PSA) test used to screen for prostate cancer in healthy men, concluding that it results in substantial harms via biopsies and surgeries that can lead to infections, impotence or urinary incontinence, and does not save men’s lives. “Amazingly, despite thousands and thousands of patients included in randomized controlled trials, there... Read More | Comment
Upvote Story 8
Until modifications in chimeric antigen receptor T-cell therapy decrease their toxicities, the intensivist will play a leading role in the management of critically ill chimeric antigen receptor T-cell patients. As this novel immunotherapeutic approach becomes widely available, all critical care clinicians need to be familiar with the recognition and management of complications associated with this treatment. This article is a comprehensive review of the available... Read More | Comment
Upvote Story 6
The efficacy of corticosteroid use in acute respiratory distress syndrome (ARDS) remains controversial. Generally, short-term high-dose corticosteroid therapy is considered to be ineffective in ARDS. On the other hand, low-dose, long-term use of corticosteroids has been reported to be effective since they provide continued inhibition of the systemic inflammatory response syndrome (SIRS) that accompanies ARDS. Thus far, no reports have been published on the efficacy... Read More | Comment
Upvote Story 6
This book collects and synthesizes the latest thinking on the condition in its variety of cognitive and behavioral presentations, matched by a variety of clinical responses. Acknowledging the continuum of injury and the multi-stage nature of recovery, expert contributors review salient research data and offer clinical guidelines for the neuropsychologist working with TBI patients, detailing key areas of impairment, brief and comprehensive assessment methods and... Read More | Comment
Upvote Story 9
A high-flow nasal cannula (HFNC) is a high-flow oxygen supply device developed in recent years and is increasingly being used to treat acute hypoxemic respiratory failure (AHRF) in intensive care unit (ICU). Patients with pre-existing chronic lung disease (CLD) often develop AHRF and require ICU admission. HFNC therapy is also used for these patients in clinical practice, although few studies have examined its efficacy. We... Read More | Comment
Upvote Story 8
Currently, TBI management is guided by clinical histories and neuroimaging techniques. While these techniques may be advanced, they are more costly than serum analysis, involve exposure to ionizing radiations, and have certain limitations when assessing brain damage severity. The ideal biomarker would stratify patients based on their severity, identifying patients with poorer prognosis and greater need for treatment before the patient’s condition worsens. Read More | Comment
Upvote Story 6
Researchers of a new study have found a link between a patient’s height and odds of survival in the intensive care unit (ICU) of the hospital. The study, published in the journal Intensive Care Medicine on Dec. 23, show that shorter patients in ICUs are more likely to die during treatment compared with taller patients. Hannah Wunsch, from Sunnybrook Hospital in Toronto, and colleagues looked... Read More | Comment
Upvote Story 5
The primary objective was to estimate the incidence of patients in the Central Denmark Region triaged to bypass the local emergency department without being part of a predefined fast-track protocol. The secondary objective was to describe these triage decisions in more detail with regard to the most common diagnoses, incidence of direct referral sorted by the prehospital critical care team (PHCCT) and the destination hospital.... Read More | Comment
Upvote Story 11
Is hyperoncotic albumin administration an unrecognized resuscitation risk factor? The use of hyperoncotic albumin (HA) for shock resuscitation is controversial given concerns about its cost, effectiveness, and potential for nephrotoxicity. We evaluated the association between early exposure to hyperoncotic albumin (within the first 48 h of onset of shock) and acute organ dysfunction in post-surgical patients with shock. Early exposure to hyperoncotic albumin in postoperative shock... Read More | Comment
Upvote Story 7
In this meta-analysis of 37 RCTs (including 9564 patients), corticosteroid treatment was significantly associated with reduced 28-day mortality, ICU mortality, and in-hospital mortality among patients with sepsis. However, this survival benefit was not replicated with 90-day mortality. Subgroup analyses based on treatment modalities demonstrated that the beneficial effect in 28-day mortality was associated with the use of low-dose corticosteroids. The association with 28-day mortality was... Read More | Comment
Upvote Story 9
In this dose-finding, phase 2 adaptive randomized trial, patients with septic shock and moderate organ dysfunction were treated early in the course of illness with low (6 g), medium (12 g), or high (18 g) doses of levocarnitine or an equivalent volume of saline placebo administered as a 12-hour infusion. None of the tested doses of levocarnitine meaningfully reduced cumulative organ failure at 48 hours.... Read More | Comment
Upvote Story 10
For patients in the ED who are suspected of having sepsis, swift, effective management is vital to improving outcomes. This issue reviews the latest evidence on the diagnosis and treatment of sepsis and septic shock: How do the definitions of sepsis affect treatment decisions – and CMS quality measurements? Is SOFA scoring in the ED possible? Is quickSOFA scoring helpful? How can you identify the... Read More | Comment
Upvote Story 5
Despite high dialysability, dialysis clearance displayed only a minor contribution to tigecycline elimination, being in the range of renal elimination in patients without AKI. No dose adjustment of tigecycline seems necessary in continuous renal replacement therapy (CRRT). A two-compartment population pharmacokinetic (PK) model was suitable to simultaneously describe the plasma PK and effluent measurements of tigecycline. Tigecycline dialysability was high, as indicated by the high... Read More | Comment
Upvote Story 8
This succinct, bulleted handbook is the ultimate resource for pulmonary and respiratory specialists. Throughout the book, tables and figures summarize important clinical data and current professional society recommendations, while salient references provide readers with the latest, evidence-based research. Divided into three sections, section one reviews the assessment process and provides practical guidance and algorithms for the evaluation of the cardinal signs of respiratory disease. Section... Read More | Comment