Delirium Treatment with Haloperidol Not Associated with Higher Risk of QTc-interval Prolongation

Delirium Treatment with Haloperidol Not Associated with Higher Risk of QTc-interval Prolongation

Delirium treatment with haloperidol and/or pipamperone was not associated with a higher risk of QTc-interval prolongation in this naturalistic patient sample but was greater in magnitude and correlated with equipotent dosage... read more

Hyperlipidemia in Immune Thrombocytopenia

Hyperlipidemia in Immune Thrombocytopenia

A high proportion of ITP patients suffered from metabolic disorders, especially hyperlipidemia. Patients with hyperlipidemia may have more severe bleeding symptoms and worse responses to ITP treatments. Statin may help... read more

Uncommon Diseases in the ICU

Uncommon Diseases in the ICU

This book highlights the practical characteristics of uncommon diseases and presents the most relevant features for the management of intensive care units. It does not aim to provide an exhaustive description of uncommon... read more

Long COVID Associated with Reduced Circulating Serotonin Levels

Long COVID Associated with Reduced Circulating Serotonin Levels

Post-acute sequelae of COVID-19 (PASC, "Long COVID") pose a significant global health challenge. The pathophysiology is unknown, and no effective treatments have been found to date. Several hypotheses have been formulated... read more

Enteral Citrulline Supplementation vs. Placebo in Mechanically Ventilated Patients

Enteral Citrulline Supplementation vs. Placebo in Mechanically Ventilated Patients

Among mechanically ventilated ICU patients without sepsis or septic shock, enteral L-citrulline administration did not result in a significant difference in SOFA score on day 7 compared to placebo. Of 120 randomized patients... read more

Roadblock: AFib with RVR

Roadblock: AFib with RVR

In this paper we focus on strategies to bypass the most common pitfalls in our treatment algorithm when treating patients who present to the ED in atrial fibrillation with RVR. We all know the few medications in our toolbox... read more

What to Know About Merkel Cell Carcinoma, the Rare Cancer that Killed Jimmy Buffett

What to Know About Merkel Cell Carcinoma, the Rare Cancer that Killed Jimmy Buffett

"Margaritaville" singer Jimmy Buffett died of Merkel cell carcinoma, a rare but aggressive form of skin cancer, according to a tribute posted on his official websiteopens in a new tab or window. The 76-year-old music icon... read more

Urine Output-based Sepsis-associated AKI: Clinical Implications

Urine Output-based Sepsis-associated AKI: Clinical Implications

This paper offers comprehensive insights into the epidemiology of acute kidney injury (AKI), and we commend the authors for their significant contribution. They revealed an increase in the number of mild cases among AKI stage... read more

TXA Should be Urgently and Broadly Adopted for Brain Bleeds

TXA Should be Urgently and Broadly Adopted for Brain Bleeds

Everything looked better with tranexamic acid (TXA), and none of it was statistically significant. True, in a subgroup analysis of patients who actually had a head bleed on imaging—which, gee whiz, seems like an important... read more

Pulmonary Hypertension: Basic Science to Clinical Medicine

Pulmonary Hypertension: Basic Science to Clinical Medicine

This book provides the framework for a singular reference in the field of pulmonary hypertension. Pulmonary vascular disease is a complex and heterogeneous condition characterized by remodeling of distal pulmonary arterioles... read more

Renal Replacement Therapy: Controversies and Future Trends

Renal Replacement Therapy: Controversies and Future Trends

Controversies and trends have always been present in nephrology. Since its inception and throughout its development, renal replacement therapy has been shrouded in uncertainty, even as it advances, and it has always been... read more

Delirium in Critically Ill Patients – Haloperidol Treatment

Delirium in Critically Ill Patients – Haloperidol Treatment

Haloperidol may reduce mortality and likely result in little to no change in the occurrence of SAEs/SARs compared with placebo in critically ill patients with delirium. However, the results were not statistically significant... read more

Artesunate Treatment in Severely Injured Patients with Traumatic Hemorrhage

Artesunate Treatment in Severely Injured Patients with Traumatic Hemorrhage

In this study of critically injured trauma patients with major hemorrhage, artesunate did not improve organ dysfunction and was potentially associated with an increased VTE risk. Future studies that focus on immune responses... read more

Adjunctive Intravenous Then Oral Vitamin C for CAP Patients

Adjunctive Intravenous Then Oral Vitamin C for CAP Patients

Patients hospitalised with community acquired pneumonia (CAP) have low peripheral blood vitamin C concentrations and limited antioxidant capacity. The feasibility of a trial of vitamin C supplementation to improve patient... read more