Tag: vitamin C

Upvote Story 4
We read with great interest the recent letter to Critical Care by Marik and Hooper. Vitamin C is increasingly recognized as a crucial compound to alleviate morbidity in critically ill patients. Vitamin C concentrations, however, are usually far below normal and even close to “scurvy levels” in this population. Vitamin C also is substantially cleared by continuous renal replacement therapy (CRRT). Significant vitamin C deficiency... Read More | Comment
Upvote Story 7
A short course of intravenous vitamin C in pharmacological dose seems a promising, well tolerated, and cheap adjuvant therapy to modulate the overwhelming oxidative stress in severe sepsis, trauma, and reperfusion after ischemia. Large randomized controlled trials are necessary to provide more evidence before wide-scale implementation can be recommended. Vitamin C is a key circulating antioxidant with anti-inflammatory and immune-supporting effects, and a cofactor for... Read More | Comment
Upvote Story 6
Sepsis resuscitation generally focuses on hemodynamics. Rivers of ink have been spilled writing about oxygen delivery and fluid responsiveness. This is clearly important, but it's possible that our focus on easily observable phenomena has led us to ignore something of equal importance: metabolic resuscitation. We can deliver all the oxygen we want to the tissues, but if the mitochondria are failing it won't work. Clinical... Read More | Comment
Upvote Story 17
Sepsis and especially septic shock (no matter what definition you use) is a recipe for multi-organ dysfunction and poor prognosis. In the past few years, we saw a lot of failed attempts trying to find something that could decrease sepsis mortality. From immunoglobulin to recombinant activated protein C, and of course Marik’s elixir (hydrocortisone, vitamin C, and thiamine). Well, the later is an unproven intervention,... Read More | Comment
Upvote Story 21
Compelling evidence obtained from in-vitro and animal studies suggest that vitamin C, a circulating antioxidant, may be a valuable adjunctive therapy in critically-ill patients. Data from humans are more conflicting. Oxalate, a well-known metabolite of vitamin C, is excreted by the kidneys and can exert a toxic effect on epithelial cells and causes direct tubular damage, and/or it can crystallize within the tubular lumen. This... Read More | Comment
Upvote Story 8
I was recently amazed to be engaged in a Twitter kerfuffle which generated more than 10,000 Impressions within 24 hours. Passions were running high, libellous comments were being broadcast, and old friendships seemed to be at breaking point. The issue? The ethics of preserving endothelial (im)permeability. This Post reflects my current perspective on things; I think I am open-minded enough to reconsider my position, so... Read More | Comment
Upvote Story 11
It is hard not to get excited about news of a potentially effective treatment for sepsis, a condition that leads to multiple organ failure and kills more people in the hospital than any other disease. The study, from Eastern Virginia Medical School in Norfolk, Va., reported some remarkable success in treating patients who were at high risk of sudden death Research has not yet confirmed... Read More | Comment