This meta-analysis aimed to examine the impact of antipyretic therapy on mortality in critically ill septic adults. Inclusion criteria were observational or randomized studies of septic patients, evaluation of antipyretic treatment, mortality reported, and English-language version available. Studies were excluded if they enrolled pediatric patients, patients with neurologic injury, or healthy volunteers. Criteria were applied by two independent reviewers.

Antipyretic treatment does not significantly improve 28-day/hospital mortality in adult patients with sepsis.

Read More