Meta-analysis confirms EGDT for sepsis is unhelpful and wasteful (PRISM)

pulmccm.org April 5, 2017

Three large, well-conducted randomized trials around the world (ProCESS, ARISE, and ProMISe) all agreed: use of early goal-directed therapy (EGDT) for sepsis does not improve mortality or any other important clinical outcome. The Big Three sepsis trials were a death knell for the formerly ubiquitous "sepsis bundles," protocols based on the single-center 2001 Rivers trial of EGDT for sepsis.