Inflammatory Subphenotypes in Patients at Risk of ARDS
We identified hyper- and non-hyperinflammatory subphenotypes in patients at risk of ARDS upon presentation to the emergency department. These subphenotypes remained identifiable over time and a hyperinflammatory subphenotype... read more
Screening Tools for Sepsis Identification
The authors undertook a rapid review to determine the suitability of sepsis screening tools in the emergency setting with regard to sensitivity and specificity of sepsis diagnosis. The review recognized that there is currently... read more
A Global Perspective on AKI After Major Surgery
Acute kidney injury (AKI) is an abrupt decline in kidney function occurring within hours or days. In patients having surgery, postoperative AKI is a major complication associated with adverse outcomes including mortality.... read more
Handbook of Critical and Intensive Care Medicine
The latest edition of this handbook is a concise yet comprehensive guide for attending physicians, fellows, residents, and students who cover the ICU. The chapters follow an outline format and are divided by organ system,... read more
ECPR for Hypothermic Refractory Cardiac Arrests in Temperate Climates
Accidental hypothermia designates an unintentional drop in body temperature below 35 °C. There is a major risk of ventricular fibrillation below 28 °C and cardiac arrest is almost inevitable below 24 °C. In such cases,... read more
ECPR in 2023
Extracorporeal cardiopulmonary resuscitation (ECPR) is invasive and resource intense. Data suggesting a survival benefit in patients after OHCA and ECPR derive from retrospective registries and meta-analyses. In order to... read more
Propofol-Related Infusion Syndrome in a Child with RSE
Propofol is used for sedation, anxiolysis, anesthesia induction, and as an anticonvulsant. In cases of refractory status epilepticus (RSE), propofol is more efficient than barbiturates. We present a case of a 3-year-old... read more
COVID-19 Severity and 2-year Prevalence of Physical Symptoms
Although the persistence of physical symptoms after SARS-CoV-2 infection is a major public health concern, evidence from large observational studies beyond one year post diagnosis remain scarce. We aimed to assess the prevalence... read more
Handbook of Intravenous Fluids
This easy to use pocket book covers all aspects of intravenous fluid therapy in critically ill patients from applied physiology to bedside clinical management succinctly. It includes updated and evidence-based content on... read more
Effect of Mechanical Ventilation Under Intubation on Respiratory Tract Change of Bacterial Count
Mechanical ventilation under intubation may cause dysregulation of lower respiratory microbiota in rats. The most common 'second strike' in mechanically ventilated patients is a pulmonary infection caused by the ease with... read more
Convalescent Plasma Cuts Death by 10% in COVID Patients on Mechanical Ventilation
A randomized clinical trial in Belgium finds that convalescent plasma reduces death rates by about 10% in COVID-19 patients requiring invasive mechanical ventilation. University of Liege researchers led the open-label... read more
Handbook of ICU Therapy
This popular handbook provides a practical guide to managing common and important problems in the critically ill patient, as well as sufficient background information to enable understanding of the principles and rationale... read more
Haloperidol Efficacy to Decrease Delirium Burden in Critically Ill Patients
This trial, that was stopped early, did not show evidence that haloperidol reduces delirium and coma in critically ill patients with delirium. The beneficial effects on some agitation-related outcomes and lower sedative... read more
Thrombocytopenia Severity in COVID-19 Patients with Epstein-Barr Virus
This study aimed to investigate the prevalence of viral co-infections in hospitalized patients and their potential association with platelet count (PLT) during hospitalization. Additionally, the study explored the gender... read more