Fully Automated, Real-time, Calibration-free, Continuous Noninvasive Estimation of Intracranial Pressure in Children

Fully Automated, Real-time, Calibration-free, Continuous Noninvasive Estimation of Intracranial Pressure in Children

This nICP estimation algorithm, based on arterial blood pressure (ABP) and bedside transcranial Doppler (TCD) cerebral blood flow velocity (CBFV) waveform measurements, performs in a manner comparable to invasive intracranial... read more

Association of Severe Hyperoxemia Events and Mortality Among Patients Admitted to a PICU

Association of Severe Hyperoxemia Events and Mortality Among Patients Admitted to a PICU

Greater numbers of severe hyperoxemia events appeared to be associated with increased mortality in this large, diverse cohort of critically ill children, supporting a possible exposure-response association between severe... read more

Defining Benefit Threshold for ECMO in Children with Sepsis

Defining Benefit Threshold for ECMO in Children with Sepsis

This binational study demonstrates that a rapidly available sepsis mortality prediction model can define thresholds for survival benefit in children with septic shock considered for ECMO. Survival on ECMO was associated... read more

Seizure Detection Algorithms in Critically Ill Children

Seizure Detection Algorithms in Critically Ill Children

Some commercially available seizure detection algorithms demonstrate performance for seizure detection that is comparable to that of electroencephalography experts using quantitative electroencephalography displays. Continuous... read more

Apneic Oxygenation As a Quality Improvement Intervention in an Academic PICU

Apneic Oxygenation As a Quality Improvement Intervention in an Academic PICU

Implementation of apneic oxygenation in PICU was feasible, and was associated with significant reduction in moderate and severe oxygen desaturation. Use of apneic oxygenation should be considered when intubating critically... read more

Clinical Profile and Predictors of Outcome of Pediatric ARDS in a PICU

Clinical Profile and Predictors of Outcome of Pediatric ARDS in a PICU

Pediatric acute respiratory distress syndrome (ARDS) contributes to a significant burden in the PICU of a developing country and is associated with significantly higher mortality. Infection remains the most common etiology.... read more

Epidemiology of Pediatric Severe Sepsis in Main PICU Centers in Southwest China

Epidemiology of Pediatric Severe Sepsis in Main PICU Centers in Southwest China

This multicenter study demonstrates that pediatric severe sepsis is common and is a factor in the high mortality rate that is observed in PICUs in Southwest China. The mortality rate remains high; therefore, improved... read more

Fentanyl Infusion Pharmacokinetics Variables in Obese and Nonobese Children

Fentanyl Infusion Pharmacokinetics Variables in Obese and Nonobese Children

The differences in total clearance (CLS) may increase less than proportional to weight in obese children greater than 6-year-olds, while volume of distribution at steady state increases more than proportional to weight in... read more

Fresh Red Blood Cell Transfusions No More Beneficial Than Older Red Blood Cells

Fresh Red Blood Cell Transfusions No More Beneficial Than Older Red Blood Cells

Researchers have found that transfusions using fresh red blood cells—cells that have spent seven days or less in storage—are no more beneficial than older red blood cells in reducing the risk of organ failure or death... read more

Ventilation Rates and Pediatric In-Hospital Cardiac Arrest Survival Outcomes

Ventilation Rates and Pediatric In-Hospital Cardiac Arrest Survival Outcomes

In this multicenter cohort, ventilation rates exceeding guidelines were common. Among the range of rates delivered, higher rates were associated with improved survival to hospital discharge. Arterial blood pressure and... read more

Timing of Tracheostomy in Pediatric Patients

Timing of Tracheostomy in Pediatric Patients

In children on mechanical ventilation, early tracheostomy may improve important medical outcomes. However, our data demonstrate the urgent need for high-quality, randomized controlled trials in the pediatric population. Data... read more

PICU Up! A Multicomponent Early Mobility Intervention for Critically Ill Children

PICU Up! A Multicomponent Early Mobility Intervention for Critically Ill Children

Pediatric intensive units traditionally have had a culture where critically ill children are intubated and mechanically ventilated, immobilized, and highly sedated. This practice is primarily driven by a focus on safety... read more

Critical Pediatric Heart Deaths Drop by 24% at Hospitals With Cardiac ICUs

Critical Pediatric Heart Deaths Drop by 24% at Hospitals With Cardiac ICUs

Major complications fall by 12%, time on a ventilator declines by 13% among children in the cardiac ICU at PC4 hospitals As a pediatric cardiology fellow nearly a decade ago, Michael Gaies remembers asking hospital colleagues... read more

An Ethical Claim for Providing Medical Recommendations in PICU

An Ethical Claim for Providing Medical Recommendations in PICU

The Declaration of Geneva was recently revised to emphasize patient autonomy and the importance of clinicians sharing medical knowledge. This reflects the welcome evolution of the doctor-patient relationship from one... read more