A world-renowned critical care doctor offers hope for ICU patients and their families in this timely, urgent, and compassionate narrative. Over the next ten years, 40 to 60 million people in this country will be admitted... read more

We aimed to compare the effects of vitamin C, glucocorticoids, vitamin B1, combinations of these drugs, and placebo or usual care on longer-term mortality in adults with sepsis or septic shock. MEDLINE, Embase, CENTRAL, ClinicalTrials.gov... read more

A personalised regimen of tapering oral corticosteroids in the presence of the anti-IL5 receptor α-directed cytolytic monoclonal antibody benralizumab can help to achieve elimination or dose reduction of oral corticosteroids... read more

This book is for everyone, nurse or otherwise, who is furious about how 2020 went down and how 2021 is going. #1 Amazon Bestseller in Critical & Intensive Care Nursing #1 Amazon Bestseller in Mental Health Nursing #1... read more

Daptomycin is an antimicrobial agent with activity against gram-positive bacteria that is usually reserved for severe infections. Acute eosinophilic pneumonia (AEP) is an increasingly rare side effect that can manifest after... read more

I have spent the past 30 years working in intensive care medicine. I was drawn to intensive care as a trainee for several reasons. First, I enjoyed the opportunity to care for the sickest patients in the hospital and to use... read more

Head rotation of 45° in anaesthetised apnoeic adults significantly increases the efficiency of mask ventilation compared with the neutral head position. Head rotation is an effective alternative to improve mask ventilation... read more

Follow Dr. Jim McCray through a single twelve-hour night shift working in the emergency room of a small Midwestern hospital. The fast-paced writing chronicles Dr. McCray’s experience with wit and candor as he manages... read more

Unlike the relatively new technologies that the mRNA and viral-vector COVID-19 shots are based on, protein vaccines have been used for decades to protect people from hepatitis, shingles and other viral infections. To elicit... read more

Seven Signs of Life encompasses intensive care stories centered around patients and as a means to explain the ICU to the non-clinician. However, Aoife Abbey organises her book by emotion, not by body system. This clever structure... read more

Waves of Covid can give you an awful sense of déjà vu. As “Hot Vax Summer” gave way early to Delta-anxious fall, you could be forgiven for feeling a familiar sense of dread, not so different from what you’d... read more

Critical illness in patients with a newly diagnosed hematologic malignancy is frequent, occurring early after diagnosis. Certain baseline characteristics can help identify those patients at the highest risk. A total of 87,965... read more

I can’t remember any time when the U.S. Food and Drug Administration had to resort to the faux-folksy mode of expression to try to get its point across. We live in strange times. The FDA was responding, of course, to... read more

Our data show that metabolic acidosis (increased strong ion gap) is associated with plasma concentration of heparan sulfate, a negatively charged glycosaminoglycan cleaved from the endothelial glycocalyx during cardiopulmonary... read more

Drugs intoxications often lead to severe vasoplegia and cardiogenic shock, and VA-ECMO represents a viable therapy option. However, as cardiopulmonary support is not contributing to the removal of the causal agent from the... read more

Severe acute respiratory syndrome coronavirus 2 (SARS–CoV–2) has led to the coronavirus disease 2019 (COVID–19) pandemic, severely affecting public health and the global economy. Adaptive immunity plays a crucial role... read more

Among patients with in-hospital cardiac arrest, administration of vasopressin and methylprednisolone, compared with placebo, significantly increased the likelihood of return of spontaneous circulation. However, there is uncertainty... read more