Clinical trials of treatments for coronavirus disease 2019 (COVID-19) draw intense public attention. More than ever, valid, transparent, and intuitive summaries of the treatment effects, including efficacy and harm, are needed.... Read More

This cohort study of 124 patients with COVID-19 revealed that most patients with COVID-19 presenting to emergency medical services were older and had multiple chronic health conditions. Initial concern, symptoms, and examination... Read More

Six months and more than ten million confirmed cases later, the COVID-19 pandemic has become the worst public-health crisis in a century. More than 500,000 people have died worldwide. It has also catalysed a research revolution,... Read More

One of the greatest challenges in health care – and in generations – is upon us COVID-19 continues to detrimentally affect every aspect of our healthcare system. Clinicians have been faced with grim life-and-death... Read More

Among patients with severe or life-threatening COVID-19, convalescent plasma therapy added to standard treatment, compared with standard treatment alone, did not result in a statistically significant improvement in time to... Read More

Although the paper is not even officially published yet, everyone has already heard the results. We have our first treatment that appears to reduce mortality in COVID-19 patients. For a week or so, we only had press release,... Read More

Controversies and trends have always been present in nephrology. Since its inception and throughout its development, renal replacement therapy has been shrouded in uncertainty, even as it advances, and it has always been... Read More

Routine whole-body computed tomography (CT) after extracorporeal cardiopulmonary resuscitation (ECPR) in out-of-hospital cardiac arrest (OHCA) patients appears to have a limited role, as the majority is caused by ACS. However,... Read More

Humanigen, the clinical stage biopharmaceutical company focused on preventing and treating cytokine storm, has reported positive data from the first clinical use of lenzilumab, its humaneered anti-human granulocyte macrophage-colony... Read More

This case demonstrates the importance of rapid recognition and treatment of hydroxychloroquine poisoning. We anticipate that clinicians may be asked to recognize and manage this toxidrome in increasing frequency as attention... Read More

Evolving experience with TEG, clotting parameters, treatment considerations, and ongoing data gathering will help us better understand if antiplatelet therapy with aspirin or clopidogrel or anticoagulant treatment with traditional... Read More

The COVID-19 pandemic is ongoing and spreading, affecting individuals in over 200 countries now. While COVID-19-related articles are being published every day, including guidelines of optimal clinical management, there are... Read More

COVID-19 has existed for less than six months, and it is easy to forget how little we know about it. The standard view is that a minority of infected people, who are typically elderly or have preexisting health problems,... Read More

This book provides the framework for a singular reference in the field of pulmonary hypertension. Pulmonary vascular disease is a complex and heterogeneous condition characterized by remodeling of distal pulmonary arterioles... Read More

Critical care teams should consider using remdesivir to treat patients with severe acute SARS-CoV-2 infection, but supply of the drug is limited and best practices for maximizing its effectiveness are not completely understood.... Read More