Haloperidol vs. Placebo in ICU Patients with Delirium

Haloperidol vs. Placebo in ICU Patients with Delirium

We assessed long-term outcomes in acutely admitted adult patients with delirium treated in intensive care unit (ICU) with haloperidol versus placebo. In acutely admitted adult ICU patients with delirium, haloperidol treatment... read more

Ilofotase Alfa Doesn’t Improved Survival Among Critically Ill Patients with SA-AKI

Ilofotase Alfa Doesn’t Improved Survival Among Critically Ill Patients with SA-AKI

Sepsis-associated acute kidney injury (SA-AKI) in patients admitted to an intensive care unit is associated with significant morbidity and mortality. There is currently no pharmaceutical treatment. Although we found no... read more

Intravenous Vitamin C for COVID-19 Patients

Intravenous Vitamin C for COVID-19 Patients

In hospitalized patients with COVID-19, vitamin C had low probability of improving the primary composite outcome of organ support–free days and hospital survival. Enrollment was terminated after statistical triggers... read more

Inflammatory Subphenotypes in Patients at Risk of ARDS

Inflammatory Subphenotypes in Patients at Risk of ARDS

We identified hyper- and non-hyperinflammatory subphenotypes in patients at risk of ARDS upon presentation to the emergency department. These subphenotypes remained identifiable over time and a hyperinflammatory subphenotype... read more

Handbook of Intravenous Fluids

Handbook of Intravenous Fluids

This easy to use pocket book covers all aspects of intravenous fluid therapy in critically ill patients from applied physiology to bedside clinical management succinctly. It includes updated and evidence-based content on... read more

Convalescent Plasma Cuts Death by 10% in COVID Patients on Mechanical Ventilation

Convalescent Plasma Cuts Death by 10% in COVID Patients on Mechanical Ventilation

A randomized clinical trial in Belgium finds that convalescent plasma reduces death rates by about 10% in COVID-19 patients requiring invasive mechanical ventilation. University of Liege researchers led the open-label... read more

Haloperidol Efficacy to Decrease Delirium Burden in Critically Ill Patients

Haloperidol Efficacy to Decrease Delirium Burden in Critically Ill Patients

This trial, that was stopped early, did not show evidence that haloperidol reduces delirium and coma in critically ill patients with delirium. The beneficial effects on some agitation-related outcomes and lower sedative... read more

Optimal RRT for Critically Ill Patients with Severe AKI

Optimal RRT for Critically Ill Patients with Severe AKI

In critically ill patients with severe acute kidney injury (AKI), initiation of continuous renal replacement therapy (CRRT), as compared to intermittent hemodialysis (IHD), was associated with a significant reduction in the... read more

Haloperidol and Delirium: What is Next?

Haloperidol and Delirium: What is Next?

Haloperidol is, by far, the best-studied antipsychotic in ICU, appears to be safe in the dosing range used in these two trials and is easy to administer and titrate. For these reasons, if a clinician chooses to pharmacologically... read more

Delirium in Critically Ill Patients – Haloperidol Treatment

Delirium in Critically Ill Patients – Haloperidol Treatment

Haloperidol may reduce mortality and likely result in little to no change in the occurrence of SAEs/SARs compared with placebo in critically ill patients with delirium. However, the results were not statistically significant... read more

AKI Defined by Fluid-Corrected Creatinine in Premature Neonates

AKI Defined by Fluid-Corrected Creatinine in Premature Neonates

In this secondary analysis of the multicenter PENUT trial, we describe fluid-corrected acute kidney injury (AKI) and evaluate associations with short-term and long-term outcomes in premature neonates with fluid-corrected... read more

Ciprofol Sedation Efficacy and Safety in Mechanical Ventilated ICU Patients

Ciprofol Sedation Efficacy and Safety in Mechanical Ventilated ICU Patients

Ciprofol was well tolerated, with a noninferior sedation profile to propofol in Chinese ICU patients undergoing MV for a period of 6–24 hours. Of the 135 patients enrolled, 129 completed the study. The primary endpoint-sedation... read more

Duration of Device-Based Fever Prevention After Cardiac Arrest

Duration of Device-Based Fever Prevention After Cardiac Arrest

While fever prevention for 72 hours after cardiac arrest has been endorsed by international guidelines since 2005, there is a lack of randomized control trial (RCT) generated data supporting this after the initial 24 hours... read more

Heterogeneous Treatment Effects of Therapeutic-Dose Heparin in Patients Hospitalized for COVID-19

Heterogeneous Treatment Effects of Therapeutic-Dose Heparin in Patients Hospitalized for COVID-19

Randomized clinical trials (RCTs) of therapeutic-dose heparin in patients hospitalized with COVID-19 produced conflicting results, possibly due to heterogeneity of treatment effect (HTE) across individuals. Better understanding... read more