Tag: sepsis
How ARDS Fuels Delirium in the ICU
This systematic review and meta-analysis evaluated 13 studies (encompassing 10,052 patients) to understand the relationship between Acute Respiratory Distress Syndrome (ARDS) and delirium. Delirium is remarkably common,... read more
Personalizing Tachycardia to Predict ICU Mortality
Traditional Systemic Inflammatory Response Syndrome (SIRS) criteria define tachycardia as a heart rate (HR) > 90 beats per minute. However, this static number is a poor screening tool for severe conditions like sepsis due... read more
Sepsis Management in Resource-limited Settings
This book is open access under a CC BY 4.0 license. It constitutes a unique source of knowledge and guidance for all healthcare workers who care for patients with sepsis and septic shock in resource-limited settings. More... read more
Decoding Sepsis: Fast-Tracking Diagnosis with SeptiCyte RAPID
SeptiCyte RAPID is an FDA-cleared gene expression test that measures a patient's immune response to help diagnose sepsis. It provides a "SeptiScore" from 0 to 15, divided into four bands that indicate the likelihood of sepsis... read more
ICU Quick Drug Guide 2nd Edition
This book provides precise, must-have drug information for the ICU. It offers essential, evidence-based practice guidelines for the critical care setting. Now in its fully revised and expanded second edition, ICU Quick Drug... read more
Handbook of Sepsis
This recently released practically oriented book provides an up-to-date overview of all significant aspects of the pathogenesis of sepsis and its management, including within the ICU. Readers will find information on... read more
Blood, Sweat, and the ICU: Conquering Emergencies in Hematological Malignancies
Breakthroughs in cancer therapies and supportive care have dramatically improved life expectancy for patients with hematological malignancies (HM). However, living longer means more patients are surviving long enough to encounter... read more
Precision at Scale: Automating the SOFA Score for Smarter ICU Care
The Sequential Organ Failure Assessment (SOFA) score is a vital tool for diagnosing sepsis and predicting patient outcomes in the ICU, but its manual calculation is often plagued by human error and scalability issues. To... read more
Breaking the Silos: How a Federated Europe Could Solve the Sepsis Puzzle
The landscape of critical care research is currently hindered by "data silos"—isolated pockets of patient information that are difficult to share due to privacy concerns and technical incompatibility. This narrative review... read more
Beyond the Pressure: Moving Toward Personalized Sepsis Care
In the high-stakes environment of septic shock, the current clinical "gold standard" remains the early initiation of norepinephrine. However, when blood pressure targets aren't met, the next steps often become a pragmatic... read more
Predicting Sepsis-associated Encephalopathy in Septic ICU Patients with AKI
Researchers developed a simple, interpretable nomogram to predict sepsis-associated encephalopathy (SAE) on day 1 in septic ICU patients who also have acute kidney injury (AKI), using data from the large MIMIC-IV database... read more
Severe Trauma and Sepsis: Organ Damage and Tissue Repair
This book discusses recent progress in organ damage and tissue repair following severe trauma and sepsis. In part 1, it introduces the theory and clinical practice in organ damage. In part 2, it covers all the subjects... read more
Metabolic Acidosis Worsens Cardiac Function and Vasopressor Needs in Septic Shock
In a prospective observational study conducted from January to December 2024 at Hospital de Especialidades No. 14, IMSS, in Veracruz, Mexico, researchers examined the cardiovascular effects of acute metabolic acidemia in... read more
Corrected Serum Calcium Levels Predict 28-Day Death Risk in Sepsis
In a large cohort study utilizing data from 7,627 sepsis patients in the eICU Collaborative Research Database, researchers uncovered a clear U-shaped relationship between corrected serum calcium (sCa) levels and 28-day mortality.... read more
Sepsis: Definitions, Pathophysiology and the Challenge of Bedside Management
A comprehensive and state-of-the-art resource for clinicians who care for patients with sepsis and research scientist alike. Patients with severe sepsis requiring ICU admission have very high rates of ICU and overall... read more
Neostigmine’s Anti-Inflammatory Edge: Cholinergic Boost Slashes Cytokines, Organ Failure, and Mortality in Septic Shock
In a randomized controlled trial, researchers investigated the adjuvant use of continuous neostigmine infusion (0.2 mg/hr for 5 days) in patients with septic shock, leveraging its ability to enhance vagal cholinergic anti-inflammatory... read more
AI Foresees the Squeeze: Machine Learning Predicts Vasopressor Needs Hours Ahead in Sepsis Patients
This proof-of-concept retrospective study, utilizing the MIMIC-IV v2.2 database (2008–2019), demonstrates that an interpretable machine learning model based on routinely collected electronic health record data from ICU... read more
Sepsis Management: PIRO and MODS
This book is unique in approaching multiple organ dysfunction syndrome (MODS) from the perspective of its pathophysiological mechanism, and addressing aspects that are overlooked in most of the available literature. Eminent... read more
Urinary Source Saves Lives: Why Infection Origin Matters in Septic Shock for Patients Over 90
In critically ill nonagenarians and centenarians admitted to ICUs with septic shock, the source of infection emerges as a key independent predictor of long-term survival, varying over time. Patients with septic shock from... read more
Obesity Paradox or Myth? BMI Shows No Impact on Sepsis Survival in ICU Patients
This retrospective cohort study examined the association between body mass index (BMI) and clinical outcomes in 559 adult ICU patients with sepsis admitted between January 2021 and December 2023. Patients were categorized... read more
Biomarkers in Trauma, Injury and Critical Care (Biomarkers in Disease: Methods, Discoveries and Applications)
This handbook systematically presents biomarkers for traumatic injuries. The book covers topics such as traumatic brain injury, liver injury, burn severity, muscle heart damage, and acute inflammation in polytrauma and their... read more
Sodium Levels and Sepsis-Related Liver Injury: A Threshold Effect
A retrospective cross-sectional study utilizing data from the MIMIC-IV database explored the relationship between serum sodium (SNa) levels and the risk of Sepsis-Related Liver Injury (SRLI) in 11,809 adult ICU patients with... read more
