Risk Factor for Superimposed Nosocomial BSI in Hospitalized COVID-19 Patients

Risk Factor for Superimposed Nosocomial BSI in Hospitalized COVID-19 Patients

Unmodified risk variables for nosocomial bloodstream infections (BSIs) included male sex and leukocytosis at admission. Using methylprednisolone and obtaining a cumulative dosage of dexamethasone were adjusted risk variables... read more

Effect of P2Y12 Inhibitors on Organ Support-Free Survival in COVID-19 Patients

Effect of P2Y12 Inhibitors on Organ Support-Free Survival in COVID-19 Patients

n this randomized clinical trial of critically ill participants hospitalized for COVID-19, treatment with a P2Y12 inhibitor did not improve the number of days alive and free of cardiovascular or respiratory organ support.... read more

Optimal Bundle of Recommendations for Sepsis

Optimal Bundle of Recommendations for Sepsis

The aim of this retrospective cohort study was to identify among the Surviving Sepsis Campaign (SSC) guidelines the optimal bundle of recommendations that minimize 28-day mortality. The bundle of six recommendations is... read more

Surfactant Therapies for Pediatric ARDS

Surfactant Therapies for Pediatric ARDS

We advocate for well-designed preclinical and explanatory clinical studies to investigate the use of surfactant for pediatric (PARDS) and neonatal (NARDS) acute respiratory distress syndrome. Given the accumulating knowledge... read more

Etomidate, Adrenal Insufficiency and Mortality Associated with Severity of Illness

Etomidate, Adrenal Insufficiency and Mortality Associated with Severity of Illness

Whereas etomidate causes adrenal insufficiency, it was not shown to increase mortality in many analyzed here in ICU settings. However, etomidate associated relative mortality rates increased progressively and correlated with... read more

Co-infection and ICU-acquired Infection in COVID-19 ICU Patients

Co-infection and ICU-acquired Infection in COVID-19 ICU Patients

In patients with severe COVID-19 in the first wave, co-infection at admission to ICU was relatively rare but antibiotic use was in substantial excess to that indication. ICU-AI were common and were significantly associated... read more

Baricitinib in COVID-19 Patients

Baricitinib in COVID-19 Patients

In patients hospitalized with COVID-19, baricitinib significantly reduced the risk of death but the size of benefit was somewhat smaller than that suggested by previous trials. The total randomized evidence to date suggests... read more

Obstructive Airway Diseases: Role of Lipid Mediators

Obstructive Airway Diseases: Role of Lipid Mediators

Incidences of inflammatory airway diseases are on the rise across the world. Existing therapeutic options are ineffective, unsafe, and expensive, and severe cases are nonresponsive to conventional therapy. Therefore, it is... read more

Association Between Dexamethasone Treatment for COVID-19 Patients and Rates of Hospital Readmission and Mortality

Association Between Dexamethasone Treatment for COVID-19 Patients and Rates of Hospital Readmission and Mortality

Current guidelines recommend use of dexamethasone, 6 mg/d, up to 10 days or until discharge for patients hospitalized with COVID-19. Whether patients who received less than 10 days of corticosteroids during hospitalization... read more

Handbook of Corticosteroids

Handbook of Corticosteroids

Corticosteroids are a class of steroid hormones which are mainly produced in the adrenal cortex of the vertebrates but are also synthesized artificially. They ease redness, itching, swelling and allergic reactions. There... read more

Inhaled Corticosteroid Use on COVID-19 Outcomes Among Hospitalized Adult Asthmatics

Inhaled Corticosteroid Use on COVID-19 Outcomes Among Hospitalized Adult Asthmatics

While our findings confirm trends observed by others with respect to risk factors among asthmatics with COVID-19, differences based on sex, ethnicity and ICS use in asthmatics were observed. Our finding that ICS use was associated... read more

The Role of Antiviral Treatment in the COVID-19 Pandemic

The Role of Antiviral Treatment in the COVID-19 Pandemic

US Food and Drug Administration (FDA) issued an emergency use authorisation for Pfizer's COVID-19 antiviral, Paxlovid few weeks ago. Trial results released by the manufacturer indicate that the drug cuts the risk of hospitalisation... read more

WHO Recommends Two New Drugs for COVID-19 Treatment

WHO Recommends Two New Drugs for COVID-19 Treatment

WHO has recommended two new drugs for COVID-19, providing yet more options for treating the disease. The extent to which these medicines will save lives depends on how widely available and affordable they will be. The... read more

Efficacy of Inhaled Ciclesonide for Outpatient Treatment with Symptomatic COVID-19

Efficacy of Inhaled Ciclesonide for Outpatient Treatment with Symptomatic COVID-19

The results of this randomized clinical trial demonstrated that ciclesonide did not achieve the primary efficacy end point of reduced time to alleviation of all COVID-19–related symptoms. A total of 413 participants... read more