Weaning protocols for discontinuation of invasive mechanical ventilation often mandate resolution of shock. Whether extubation while receiving vasopressors is associated with harm is uncertain. To examine whether extubation... read more

Offering essential, evidence-based practice guidelines specifically for the critical care setting, ICU Quick Drug Guide contains up-to-date information in a quick-access format. This portable handbook provides fast, accurate... read more

While there have been extensive analyses characterizing cellular and humoral responses across the severity spectrum in COVID-19, predictors of outcomes within severe COVID-19 remain to be comprehensively elucidated. Recently,... read more

This text reviews the postoperative management of patients who have undergone cardiac surgical procedures, some of the most common and most complicated forms of surgery. These patients and their management are characterized... read more

Two doses of SCB-2019 vaccine plus CpG and alum provides notable protection against the entire severity spectrum of COVID-19 caused by circulating SAR-CoV-2 viruses, including the predominating delta variant. This ongoing... read more

Calculating equipotent doses between vasopressor agents is necessary in clinical practice and research pertaining to the management of shock. This scoping review summarizes conversion ratios between vasopressors and provides... read more

Ketamine has suggested potential benefit in several disease states impacting critically ill patients including pain, alcohol withdrawal syndrome, status epilepticus, and acute agitation. Further supporting evidence is needed... read more

Now in its sixth edition, the Handbook of Drugs in Intensive Care is the essential guide to using drugs safely and effectively in the intensive care setting. The book is split into two sections: an A-Z guide to the drugs... read more

In this cohort study of patients with acute, non–life-threatening hyperkalemia, a single dose of patiromer was associated with a significant decrease in serum potassium levels and a low incidence of hypokalemia. These findings... read more

This book is an introduction to a comprehensive analysis of recent advances and clinical research in noninvasive mechanical ventilation (NIV) in Pulmonary, Critical Care, and Sleep Medicine. The objective of the book is to... read more

SARS-CoV-2 infection is benign in most individuals but, in approx. 10% of cases, it triggers hypoxemic COVID-19 pneumonia, which becomes critical in ˜3% of cases. The ensuing risk of death (˜1%) doubles every five years... read more

I have discussed the ongoing battle between normal saline and ‘balanced fluids’ many times in the past. First, there was the SPLIT trial, a double blind cluster RCT of 2200 ICU patients that showed no difference between... read more

This workbook focuses on hemodynamics management. Hemodynamic management should be aimed at minimizing the ischemic injury. Cerebral ischemia impairs the brain’s ability to autoregulate its circulation through vasoconstriction... read more

The aim of these guidelines is to provide evidence‑based guidance for temperature control in adults who are coma‑tose after resuscitation from either in-hospital or out-of-hospital cardiac arrest, regardless of the underlying... read more

The ICU technique of placing a hypoxic patient in a prone position is being widely used to care for COVID-19 patients in respiratory distress to improve oxygenation and possibly to avoid intubation. The COVID-19 pandemic... read more

In a population of patients without severely impaired baseline renal function receiving fewer than 10 erythrocyte units, duration of blood storage had no effect on the incidence of posttransfusion acute kidney injury (AKI).... read more

Early deaths are likely related to the ongoing CPFA treatment, for reasons that if identified could allow some deaths to be prevented. We hypothesize a connection to hemodynamic instability consequent on renal replacement... read more

There was nonlinear relationship between fluid balance and all three tiers of ventilator-associated event, with an fluid balance between –1 and 0 L corresponding to the lowest risk. Positive but not negative fluid balance... read more