Intravenous fluid administration is an integral part of patient management during anesthesia. This practice has a strong clinical rationale since a decrease in blood volume, either present before or developing during surgery,... Read More

Recent reports from China, Italy, and the US indicate that there is a 25-37% incidence of AKI among critically ill COVID-19 patients (Singh 2020, Hirsch et al. 2020). In a study of 5,449 hospitalized COVID-19 patients, acute... Read More

Acute kidney injury (AKI) has been reported in up to 25% of critically-ill patients with SARS-CoV-2 infection, especially in those with underlying comorbidities. AKI is associated with high mortality rates in this setting,... Read More

Frank Ruschitzka told his pathologist to be ready before the first COVID-19 patient died. In early March, Ruschitzka, who leads the cardiology department at University Hospital Zürich, noticed that patients with the disease... Read More

Gilead’s first Randomized Controlled Trial on remdesivir was just published, and it’s very interesting. This is a trial designed, monitored, and written by Gilead. In some ways, the design of the trial and its... Read More

Proper fluid management while avoiding fluid overload can be one of the most difficult parts of practicing medicine. Unfortunately, many physicians using ultrasound mainly rely on Inferior Vena Cava (IVC) measurements to... Read More

Join Dr. David Lyness as he discusses the current evidence on COVID-19 in Intensive Care. A coronavirus is one of many viruses that cause diseases in mammals and birds. In humans, coronaviruses cause respiratory tract infections... Read More

In this cohort study, compared with non-dialysis care, patients who received maintenance dialysis spent more time in the hospital and were more likely to be admitted to intensive care units. This finding suggests trade-offs... Read More

This study suggests that empirical anti-MRSA therapy was not associated with reduced mortality for any group of patients hospitalized for pneumonia. These results contribute to a growing body of evidence that questions the... Read More

The authors concluded that high suPAR levels were associated with Acute Kidney Injury (AKI) in various clinical and experimental contexts. This cohort study reports that suPAR was associated with subsequent AKI in several... Read More

Using the KDIGO criteria for both serum creatinine and urine output to define acute kidney injury (AKI), 39.8% of patients between the ages of 16–25 met AKI criteria during admission to an adult tertiary care center, indicating... Read More

D-Dimer cutoff levels adjusted for renal dysfunction appear feasible and safe assessing thromboembolic disease in critically ill patients. Furthermore, adjusted D-dimer cutoff levels seem reliable in patients with acute kidney... Read More

Imagine that you admit a patient with septic shock. You resuscitate the patient as best you can with inopressors, fluids, and antibiotics. An adequate blood pressure is achieved. A reasonable amount of fluid is administered.... Read More

This study suggests that predialysis level of serum lactate level is an important marker of mortality in MALA patients requiring renal replacement therapy (RRT) with a linear dose-response relationship. To better evaluate... Read More

Clinical variables, especially the reason for ICU admission, are associated with the development of chronic conditions after ICU discharge. Therefore, these clinical variables should be considered when organizing follow-up... Read More