COVID-19 Vaccine: Safety and Efficacy

COVID-19 Vaccine: Safety and Efficacy

Two doses of SCB-2019 vaccine plus CpG and alum provides notable protection against the entire severity spectrum of COVID-19 caused by circulating SAR-CoV-2 viruses, including the predominating delta variant. This ongoing... read more

Neurological Complications After First Dose of COVID-19 Vaccines

Neurological Complications After First Dose of COVID-19 Vaccines

Emerging reports of rare neurological complications associated with COVID-19 infection and vaccinations are leading to regulatory, clinical and public health concerns. We undertook a self-controlled case series study to investigate... read more

CCSC Encourage Flu Shots Amid COVID-19 Spread

CCSC Encourage Flu Shots Amid COVID-19 Spread

The members of the Critical Care Societies Collaborative (CCSC), which includes the American Association of Critical-Care Nurses (AACN), American College of Chest Physicians (CHEST), American Thoracic Society (ATS), and Society... read more

Clinical Trial of Therapeutics for Severely Ill Hospitalized COVID-19 Patients Begins

Clinical Trial of Therapeutics for Severely Ill Hospitalized COVID-19 Patients Begins

A new Phase 3 trial to test the safety and efficacy of therapeutics for COVID-19 has begun enrolling patients hospitalized with life-threatening cases of COVID-19, including those with acute respiratory failure. The trial... read more

The Blood-Clot Problem Is Multiplying

The Blood-Clot Problem Is Multiplying

For weeks, Americans looked on as other countries grappled with case reports of rare, sometimes fatal blood abnormalities among those who had received the AstraZeneca vaccine against COVID-19. That vaccine has not yet... read more

Understanding The Links Between COVID-19 Vaccines and Thrombosis

Understanding The Links Between COVID-19 Vaccines and Thrombosis

The Advisory Committee on Immunization Practices (ACIP) is convening an emergency meeting to discuss adverse events that recently led to thrombotic events in 6 women administered the Johnson & Johnson COVID-19 vaccine in... read more

An overview of the current AstraZeneca vaccine situation in Europe

An overview of the current AstraZeneca vaccine situation in Europe

On Thursday, March 11, 2021, Denmark suspended the use of the AstraZeneca vaccine (developed in collaboration with the University of Oxford) completely. Some other European countries followed suit. This prompted an investigation... read more

Janssen Investigational COVID-19 Vaccine

Janssen Investigational COVID-19 Vaccine

An investigational COVID-19 vaccine developed by Janssen Pharmaceuticals appears to be safe and effective at preventing moderate and severe COVID-19 in adults, according to an interim analysis of Phase 3 clinical data conducted... read more

Allergic Reactions After First Dose of Pfizer-BioNTech COVID-19 Vaccine

Allergic Reactions After First Dose of Pfizer-BioNTech COVID-19 Vaccine

Anaphylactic reactions to the first dose of the Pfizer-BioNTech COVID-19 vaccine are rare, usually occur within 30 minutes of administration, and are readily treatable. From December 14-23, 2020, following administration... read more

COVID-19: Antibody-Dependent Enhancement

COVID-19: Antibody-Dependent Enhancement

The simple definition of ADE is “raising antibodies that don’t protect, but actually make a viral infection even worse”. And obviously, that’s the opposite of what you want. Remember that there are “neutralizing”... read more

Allergic Reactions After Receipt of the First Dose of Pfizer-BioNTech COVID-19 Vaccine

Allergic Reactions After Receipt of the First Dose of Pfizer-BioNTech COVID-19 Vaccine

Early safety monitoring of the Pfizer-BioNTech COVID-19 vaccine has detected 21 cases of anaphylaxis after reported administration of 1,893,360 first doses of Pfizer-BioNTech COVID-19 vaccine (11.1 cases per million vaccine... read more

Allergic Reactions to COVID-19 Vaccine

Allergic Reactions to COVID-19 Vaccine

To date, the development of mRNA vaccines for the prevention of infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a success story, with no serious concerns identified in the ongoing... read more

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

The mRNA-1273 vaccine showed 94.1% efficacy at preventing COVID-19 illness, including severe disease. Aside from transient local and systemic reactions, no safety concerns were identified. The trial enrolled 30,420 volunteers... read more

The Risk of False Negative Results with the Curative COVID-19 Test

The Risk of False Negative Results with the Curative COVID-19 Test

The U.S. Food and Drug Administration (FDA) is alerting patients and health care providers of the risk of false results, particularly false negative results, with the Curative SARS-Cov-2 test. Risks to a patient of a... read more