Impact of the Timing of Invasive Mechanical Ventilation in Sepsis Patients

In patients with sepsis admitted to ICU and received invasive mechanical ventilation (MV), early MV was associated with lower ICU and in-hospital mortality and a shorter ICU stay. Additionally, at ICU discharge, early MV... read more

Tags: ARDS, ARF, COVID-19, HFNC, ICU, mechanical ventilation, pneumonia, sepsis, SOFA, ventilation,

Severe Trauma and Sepsis: Organ Damage and Tissue Repair

This book discusses recent progress in organ damage and tissue repair following severe trauma and sepsis. In part 1, it introduces the theory and clinical practice in organ damage. In part 2, it covers all the subjects of... read more

Tags: book, education, infection, inflammation, sepsis, trauma,

Iloprost and Organ Dysfunction in Adults With Septic Shock and Endotheliopathy

In this randomized clinical trial of adults in the ICU with septic shock and severe endotheliopathy, infusion of iloprost, 1 ng/kg/min, for 72 hours did not reduce mean daily SOFA scores compared with placebo. In a clinical... read more

Tags: ICU, infusion, sepsis, septic shock, SOFA, vasodilation,

Veno-Arterial-Venous ECMO in a Patient Undergoing Dialysis and Having Cardiopulmonary Failure Due to COVID-19

COVID-19 can cause cardiomyopathy, a rare cardiovascular disorder that can lead to cardiogenic shock. The cardiac and respiratory symptoms may not occur simultaneously, and it is possible to switch to veno-arterial-venous... read more

Tags: cardiogenic shock, cardiomyopathy, COVID-19, CT, ECMO, hypertension, oxygenation, study, tomography,

ECMO in the Adult Patient (Core Critical Care)

Extracorporeal membrane oxygenation (ECMO) is developing rapidly, and is now part of the toolkit for the management of all patients with severe respiratory or cardiac failure. Clinicians of all disciplines are in need of... read more

Tags: book, ECMO, oxygenation, technology, tools,

Respiratory Effort in Mechanical Ventilation Weaning Prediction

This study demonstrates that PMI and ΔPocc are effective in predicting weaning outcomes in patients with DT≥2mm. The effectiveness of P0.1 in assessing weaning is also significantly higher in this subgroup. These findings... read more

Tags: mechanical ventilation, PEEP, SBT, study, ventilation, weaning,

Human albumin solution for on-pump cardiac surgery: benefit or burden?

Deidentified individual participant data collected during the HAS FLAIR-II trial (and the data dictionary) will be shared beginning two years after article publication with no end date. These data will be available to researchers... read more

Tags: albumin, ICU, research, sepsis, septic shock, study,

Trauma Team Dynamics: A Trauma Crisis Resource Management Manual

This is the first book exploring the unique dynamics created by a multidisciplinary trauma team and how crisis management strategies can improve teamwork and communication and, potentially, improve patient resuscitation... read more

Tags: book, education, ICU, nursing, resuscitation, therapy, trauma,

Adiposity and Mortality Among ICU Patients with COVID-19 and Non-COVID-19 Respiratory Conditions

Obesity is associated with higher mortality among COVID-19 patients, but lower mortality among non-COVID-19 respiratory patients. These associations appear vulnerable to confounding/selection bias in both patient groups,... read more

Tags: COVID-19, ICU, mortality, obesity, pneumonia, study,

Sex Differences in the Outcome of Critically Ill COVID-19 Patients

Among patients admitted to ICU for severe COVID-19, males experienced higher severity of illness and more frequent intervention than females. Ultimately, the hazard of death was moderately elevated in males compared to females... read more

Tags: COVID-19, ICU, mechanical ventilation, study, tracheostomy, vasopressors, ventilation,

Optimizing Oxygenation For Tracheal Intubation in Critically Ill Patients

Tracheal intubation (TI) is a common procedure frequently performed in critically ill patients and is an integral part of emergency airway management (EAM). However, it carries inherent risks and can significantly impact... read more

Tags: HFNO, hypoxemia, hypoxia, ICU, intubation, NIV, oxygenation, study, ventilation,

Functional Dependence Following ICU-treated Sepsis

Sepsis survivorship was associated with a broad range of new impairments and led to functional dependence in around one quarter of patients. Targeted measures are needed to mitigate the burden of this Post-Sepsis-Syndrome... read more

Tags: COVID-19, ICU, sepsis, treatment,

Resuscitation Arterial Waveform Quantification and Outcomes in Pediatric Patients

Providing physiologically adequate CPR for pediatric single ventricle patients palliated with Bidirectional Glenn (BDG) or Fontan physiology is challenging. Only 27% of Fontan patients survived to hospital discharge with... read more

Tags: CHD, CPR, ECMO, hemodynamics, pediatrics, resuscitation,

Reducing Deep Sedation and Benzodiazepine Use in Mechanically Ventilated Patients During Critical Care Transport

The rate of deep sedation in this cohort was consistent with previously published data; however, it remains higher than clinically indicated. Over the course of the QI project, the proportion of deeply sedated patients without... read more

Tags: guidelines, mechanical ventilation, sedation, ventilation,

Feeding Challenges in the ICU

For critically ill patients, timely nutritional support can aid recovery and reduce mortality risk. But what about a patient in septic shock who is receiving vasopressor therapy, or one who requires prone positioning or extracorporeal... read more

Tags: acidosis, guidelines, ICU, ischemia, nutrition, vasopressors,

Pediatric Critical Care: A Primer for All Clinicians

Pediatric critical care is an emotionally and intellectually demanding field of medicine; however, it is at its core the discipline focused on saving and improving the lives of children affected by acute and chronic illnesses,... read more

Tags: book, education, mechanical ventilation, pediatrics, reference, resuscitation, sepsis,

Improving Patient Outcomes: Sepsis Protocols and Rapid Host Response Technologies

Patients come into the emergency department (ED) with symptoms, not diagnoses. That’s when time is of the essence. Clinicians must quickly triage patients and establish an appropriate care pathway to obtain the best possible... read more

Tags: CT, diagnosis, sepsis, technology, tomography, troponin,

Hemodynamic Monitoring Using Echocardiography in the Critically Ill

The hemodynamic evaluation of patients with acute circulatory failure and respiratory failure has in the past usually been performed using invasive procedures but in recent years less invasive monitoring devices have been...

Confessions of a Surgeon

Confessions of a Surgeon: The Good, the Bad, and the Complicated… Life Behind the O.R. Doors. As an active surgeon and former department chairman, Dr. Paul A. Ruggieri has seen the good, the bad, and the ugly of his...