This well-illustrated book provides detailed guidance on all aspects of physical examination in patients requiring emergency or intensive care. After an introductory section covering basic principles and the recognition of... Read More

TEE accurately predicts invasive PAOP ≤ 18 mmHg in ventilated patients. This further increases its diagnostic value in patients with suspected acute lung injury/acute respiratory distress syndrome. During two consecutive... Read More

This is the first study to demonstrate that the active form of GSDM-D is found exclusively in the circulation of septic critically ill patients raising its potential as an agent of dysregulated immunity in systemic infection.... Read More

In this preliminary study of patients with sepsis and Acute Respiratory Distress Syndrome (ARDS), a 96-hour infusion of vitamin C compared with placebo did not significantly improve organ dysfunction scores or alter markers... Read More

In patients with Acute Respiratory Distress Syndrome (ARDS), plateau pressure, driving pressure, and respiratory system compliance can be measured during assisted ventilation, and both higher driving pressure and lower compliance... Read More

Acute respiratory distress syndrome (ARDS) is common in mechanically ventilated patients with cirrhosis but is not independently associated with increased mortality. The mean age in 181 eligible patients was 53 ± 11 years;... Read More

Treatment with noninvasive ventilation (NIV) did not reduce the need for intubation among patients with pneumonia-induced early mild acute respiratory distress syndrome (ARDS), despite the improved PaO2/FIO2 observed with... Read More

Ultra-protective lung ventilation on ECMO was largely adopted across medium to high case-volume ECMO centers. In contrast with previous observations, mechanical ventilation settings during ECMO did not impact patients’... Read More

This study highlights the kinetics of endocan in severe sepsis and acute respiratory distress syndrome (ARDS), thus helping to understand the apparently conflicting results observed in the literature. However, the interpretability... Read More

The provision of procalcitonin assay results, along with instructions on their interpretation, to emergency department and hospital-based clinicians did not result in less use of antibiotics than did usual care among patients... Read More

Survivors of critical illness frequently experience poor physical outcomes, including persistent impairments in muscle strength, exercise capacity and physical function. In this article, we review these impairments and recent... Read More

Compelling evidence obtained from in-vitro and animal studies suggest that vitamin C, a circulating antioxidant, may be a valuable adjunctive therapy in critically-ill patients. Data from humans are more conflicting. Oxalate,... Read More

Despite low mean tidal volume in the cohort, a significant percentage of patients were exposed to a prolonged duration of high tidal volumes which was correlated with higher mortality. Detailed ventilator records in the electronic... Read More

Significant variability in potential for lung recruitment in patients with severe acute respiratory distress syndrome (ARDS) requiring extracorporeal membrane oxygenation (ECMO). 47 adults with severe ARDS requiring ECMO... Read More