Anticoagulation Reversal Strategies for Warfarin Associated Acute Gastrointestinal Bleeding

Patients who received prothrombin complex concentrate (PCC) had a threefold increase in mortality compared to fresh frozen plasma (FFP), vitamin K alone, or no reversal, even after adjusting for severity of the bleeding.... read more

Endotracheal Tube Cuff Pressure Monitoring and VAP Occurrence

This study demonstrated that maintaining endotracheal tube cuff pressure at 30 cm H2O through monitoring every 8 h did not result in a greater incidence of under-inflation (pressures ... read more

Biomarkers in Trauma, Injury and Critical Care (Biomarkers in Disease: Methods, Discoveries and Applications)

This handbook systematically presents biomarkers for traumatic injuries. The book covers topics such as traumatic brain injury, liver injury, burn severity, muscle heart damage, and acute inflammation in polytrauma and their... read more

Biomarkers in Trauma, Injury and Critical Care (Biomarkers in Disease: Methods, Discoveries and Applications)

Association Between Initial Blood Product Transfusion with a Higher Plasma-to-red Blood Cell Ratio and Mortality in Adults with Severe Bleeding Following Trauma

This study demonstrates that a high fresh-frozen plasma (FFP) to packed red blood cells (PRBC) ratio (>1:1.5) is associated with reduced 24-hour and 30-day mortality rates among trauma patients with massive hemorrhage. However,... read more

Intubating the Critically Ill Patient: A Step-by-Step Guide for Success in the ED and ICU

Intubating critically ill patients is a process that requires a well-thought-out, step-by-step plan, specific to each patient. This book teaches the steps necessary to predict, prepare, perform, and provide pre and post-intubation... read more

Intubating the Critically Ill Patient: A Step-by-Step Guide for Success in the ED and ICU

Hemodynamic Stabilization Using CRRT and cIVNa Combination Therapy

Compared with conventional continuous renal replacement therapy (CRRT), combination therapy of CRRT and continuous intravenous sodium infusion therapy (cIVNa) increased blood pressure, enhanced urinary volume, and reduced... read more

Hemodynamic Monitoring in the ICU

This book describes the pathophysiological significance of the hemodynamic monitoring parameters available to the clinician and their role in providing reliable and reproducible information on the cardiocirculatory status... read more

Hemodynamic Monitoring in the ICU

A Novel Mechanism for COVID-19 Related Thrombotic Events: Platelet NO/ROS Equilibrium

The finding that platelet NO/ROS production imbalance contributes to the elevated risk of thrombotic events in COVID-19 has important clinical implications. Restoration of platelet NO production, as well as attenuation... read more

Inadequate Empirical Antibiotic Therapy in VAP: Risk Factors and Outcomes

Ventilator-associated pneumonia (VAP) caused by MDR pathogens were highly likely to receive inadequate empirical antibiotic therapy. The mortality rate and intubation duration were significantly longer in inadequately treated... read more

Red Book: Report of the Committee on Infectious Diseases

Extending an 8-decade tradition of excellence, Red Book® provides the most reliable and clinically useful information on the manifestations, etiology, epidemiology, diagnosis and treatment of more than 200 childhood infectious... read more

Red Book: Report of the Committee on Infectious Diseases

Early Acetaminophen Administration Associated with Lower Mortality Among ARDS Patients After Coronary Artery Bypass Grafting

The use of acetaminophen (APAP) at 48h after coronary artery bypass grafting (CABG)-acute respiratory distress syndrome (CABG-ARDS) was associated with lower early postoperative mortality, while shortening the length of hospital... read more

Thirst Management in Orotracheally Intubated and Mechanically Ventilated Patients

Symptom Management Theory (SMT)-based thirst management is an effective strategy. The 5 mL cold water spray method significantly reduces thirst intensity and distress in mechanically ventilated patients under fasting and... read more

COVID-19 Handbook: Navigating the Future of Healthcare

The COVID-19 Handbook: Navigating the Future of Healthcare provides factual, evidence-based information on the coronavirus disease 2019 (COVID-19) pandemic. Presented in a concise PDF format, this valuable COVID-19 resource... read more

COVID-19 Handbook: Navigating the Future of Healthcare

Serum MANF vs. Severity and Prognosis in Community-acquired Pneumonia Patients

This evidence demonstrated that serum mesencephalic astrocyte-derived neurotrophic factor (MANF) is positively associated with scoring criteria and poor prognosis in community-acquired pneumonia (CAP) patients. Serum... read more

Tocilizumab vs. IVIG in Patients with Severe COVID-19 Pneumonia

Severe COVID-19 patients who received IVIG in the early phase of the disease did not show better clinical outcomes in terms of mortality, hospitalization time and intensive care unit admission compared to those who received... read more

Management of Chest Trauma: A Practical Guide

75% of patients who die from trauma have injuries to the chest. The care of the chest trauma patient can be incredibly complex, require multiple specialty and sub-specialty services, and may require interventions available... read more

Management of Chest Trauma: A Practical Guide

Holy Water Not so Holy: Potential Source of Elizabethkingia Pneumonia and Bacteremia in an Immunocompromised Host

This case report highlights that E. anophelis may indeed cause significant infection and should not be considered a contaminant especially in immunosuppressed individuals. The organism originates from water sources and may... read more

Levosimendan Role in ECMO for Refractory Cardiac Arrest

Levosimendan use in extracorporeal cardiopulmonary resuscitation (ECPR) did not improve survival. Neurological outcome could be representative of the short- and long-term outcomes. Future well-designed randomized trials... read more

Fever Management with or without a Temperature Control Device After OHCA and Resuscitation

the TEMP‐CARE trial will advance our understanding of post‐cardiac arrest care fever management strategies. With a large sample size and a broad patient population, the results of this trial will inform clinical practice... read more

50 Landmark Papers Every Intensivist Should Know

This book identifies the key scientific articles in the field of Intensive Care and explains why these papers are important in contemporary clinical management. Identifying those influential contributors who have shaped... read more

50 Landmark Papers Every Intensivist Should Know

Ventilator-associated Pneumonia Pathogenesis: Old and New Mechanisms

Ventilator-associated pneumonia (VAP), defined as a lung infection that occurs in patients after 48 hours on mechanical ventilation, is among the most frequently found nosocomial infections in intensive care units around... read more

Aminoglycosides Impact on Survival Rate and Renal Outcomes in Patients with Urosepsis

The addition of aminoglycosides to beta-lactam therapy in critically ill patients with urosepsis did not significantly improve 30-day survival. Furthermore, aminoglycosides were not associated with worse renal outcomes.... read more