As remarked by the authors of the recent PLUS trial, a systematic review and meta-analysis of randomized controlled trials comparing balanced resuscitation fluid to 0.9% saline was reported in the New England Journal of Medicine... read more

The novel coronavirus 2019 (COVID-19) has caused a serious global pandemic in just eight months. Nearly every country and territory in the world has been affected by the virus. The virulence and infection rate of the virus... read more

Participants randomized to external forced-air warming did not have a difference in HLA-DR expression or IFN-γ production. In this pilot study, however, 28-day mortality was lower in the intervention group. Future research... read more

This book contains all the information that readers will require in order to perform echocardiography and to interpret the findings correctly. After an introductory chapter on the essential physics of ultrasonography, standard... read more

Widespread uptake of COVID-19 vaccines that are highly effective against severe illness and death, the accrual of high rates of vaccine- and infection-induced immunity at the population level, and the availability of effective... read more

Delirium represents a form of acute brain dysfunction predictive of excess death and long-term cognitive impairment in critically ill patients. For many years, we have wondered whether pharmacological doses of melatonin would... read more

Early mobilisation of mechanically ventilated patients has been suggested to be effective in mitigating muscle weakness, yet it is not a common practice. Understanding staff experiences is crucial to gain insights into what... read more

This book is designed to offer the reader first-rate guidance on shock management in the real world. Comprehensive, evidence-based, and up-to-date instruction is provided on optimal care of patients with different types of... read more

The Pediatric Acute Lung Injury Consensus Conference “at-risk for pediatric acute respiratory distress syndrome” criteria identify critically ill children at high risk of pediatric acute respiratory distress syndrome... read more

The trial did not show that prehospital PRBC–LyoPlas resuscitation was superior to 0·9% sodium chloride for adult patients with trauma related hemorrhagic shock. Further research is required to identify the characteristics... read more

In this study, the relevant RCTs on cognitive exercise in ICU inpatients with delirium were screened for systematic evaluation and meta-analysis, aiming to explore the impact of cognitive exercises and routine nursing on... read more

A trauma patient required emergent intubation during a recent shift. The altered patient was suspected of having an intracranial bleed. My resident was concerned about rapid onset of hypoxia and other internal injuries causing... read more

Buprenorphine-precipitated opioid withdrawal is seen in patients physically dependent on opioids who have recently taken full-agonist opioids and are then administered buprenorphine. Patients with severe withdrawal commonly... read more

By reading this article, you should be able to: – Identify the predictors of successful extubation in pediatric ICU (PICU) patients. – Describe the factors affecting mechanical ventilator weaning in PICU patients.... read more

This book provides a comprehensive, state-of-the art review of the interventional procedures that can be performed in intensive care settings. The book addresses fundamentals of the indications and technical aspects of procedures,... read more

Adult sepsis survivors experience an increased hazard of major cardiovascular events compared to survivors of a non-sepsis hospitalization. 254,241 adult sepsis survivors were matched to adult survivors of non-sepsis hospitalization... read more

This study compared the effect of placebo versus the bradykinin B2 receptor antagonist icatibant on symptoms of ACE inhibitor–associated angioedema in a mixed race population of patients. The study does not support the... read more